ENSMUSG00000020788


Mus musculus

Features
Gene ID: ENSMUSG00000020788
  
Biological name :Atp2a3
  
Synonyms : Atp2a3 / Q64518 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
  
Possible biological names infered from orthology : ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 / Q93084
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B4
Gene start: 72961169
Gene end: 72993044
  
Corresponding Affymetrix probe sets: 10378216 (MoGene1.0st)   1421129_a_at (Mouse Genome 430 2.0 Array)   1450124_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104125
Ensembl peptide - ENSMUSP00000127036
Ensembl peptide - ENSMUSP00000104126
Ensembl peptide - ENSMUSP00000021142
Ensembl peptide - ENSMUSP00000104124
NCBI entrez gene - 53313     See in Manteia.
MGI - MGI:1194503
RefSeq - NM_001163336
RefSeq - NM_001163337
RefSeq - NM_016745
RefSeq Peptide - NP_001156808
RefSeq Peptide - NP_001156809
RefSeq Peptide - NP_058025
swissprot - Q8R0X5
swissprot - B1ATS5
swissprot - B1ATS4
swissprot - Q64518
swissprot - E9Q559
Ensembl - ENSMUSG00000020788
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp2a3ENSDARG00000060978Danio rerio
 ATP2A3ENSGALG00000001564Gallus gallus
 ATP2A3ENSG00000074370Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atp2a2 / O55143 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 / P16615* / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2*ENSMUSG0000002946775
Atp2a1 / Q8R429 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 / O14983* / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1*ENSMUSG0000003073073
Atp2c1 / Q80XR2 / Calcium-transporting ATPase type 2C member 1 / P98194* / ATPase secretory pathway Ca2+ transporting 1*ENSMUSG0000003257031
A7L9Z8 / Atp2c2 / Calcium-transporting ATPase type 2C member 2 / O75185* / ATPase secretory pathway Ca2+ transporting 2*ENSMUSG0000003411230
Atp1a4 / Q9WV27 / Sodium/potassium-transporting ATPase subunit alpha-4 / Q13733* / ATPase Na+/K+ transporting subunit alpha 4*ENSMUSG0000000710729
Atp4a / ATPase H+/K+ transporting alpha subunit / P20648*ENSMUSG0000000555329
Atp1a2 / Q6PIE5 / Sodium/potassium-transporting ATPase subunit alpha-2 / P50993* / ATPase Na+/K+ transporting subunit alpha 2*ENSMUSG0000000709729
Atp1a3 / Q6PIC6 / Sodium/potassium-transporting ATPase subunit alpha-3 / P13637* / AC010616.2* / ATPase Na+/K+ transporting subunit alpha 3*ENSMUSG0000004090728
Atp1a1 / Q8VDN2 / Sodium/potassium-transporting ATPase subunit alpha-1 / P05023* / ATPase Na+/K+ transporting subunit alpha 1*ENSMUSG0000003316128
Atp12a / Q9Z1W8 / Potassium-transporting ATPase alpha chain 2 / P54707* / ATPase H+/K+ transporting non-gastric alpha2 subunit*ENSMUSG0000002222927


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR004014  Cation-transporting P-type ATPase, N-terminal
 IPR005782  P-type ATPase, subfamily IIA, SERCA-type
 IPR006068  Cation-transporting P-type ATPase, C-terminal
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR023214  HAD superfamily
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR030330  Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0099132 ATP hydrolysis coupled cation transmembrane transport IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum ISO
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005388 calcium-transporting ATPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Reduction of cytosolic Ca++ levels
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004036 abnormal muscle relaxation "altered ability of the muscle to lengthen following contractions" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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