ENSG00000074370


Homo sapiens

Features
Gene ID: ENSG00000074370
  
Biological name :ATP2A3
  
Synonyms : ATP2A3 / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 / Q93084
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: p13.2
Gene start: 3923870
Gene end: 3964464
  
Corresponding Affymetrix probe sets: 207521_s_at (Human Genome U133 Plus 2.0 Array)   207522_s_at (Human Genome U133 Plus 2.0 Array)   213036_x_at (Human Genome U133 Plus 2.0 Array)   213042_s_at (Human Genome U133 Plus 2.0 Array)   230453_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000380236
Ensembl peptide - ENSP00000380234
Ensembl peptide - ENSP00000458865
Ensembl peptide - ENSP00000461480
Ensembl peptide - ENSP00000301387
Ensembl peptide - ENSP00000312577
Ensembl peptide - ENSP00000353072
Ensembl peptide - ENSP00000380229
NCBI entrez gene - 489     See in Manteia.
OMIM - 601929
RefSeq - XM_017024693
RefSeq - NM_174956
RefSeq - NM_174957
RefSeq - NM_174958
RefSeq - XM_011523881
RefSeq - XM_011523882
RefSeq - XM_011523884
RefSeq - XM_011523885
RefSeq - XM_011523888
RefSeq - XM_011523889
RefSeq - XM_017024692
RefSeq - NM_005173
RefSeq - NM_174953
RefSeq - NM_174954
RefSeq - NM_174955
RefSeq Peptide - NP_777613
RefSeq Peptide - NP_777614
RefSeq Peptide - NP_777615
RefSeq Peptide - NP_777616
RefSeq Peptide - NP_777617
RefSeq Peptide - NP_777618
RefSeq Peptide - NP_005164
swissprot - A0A0C4DGN1
swissprot - A0A0C4DGN3
swissprot - Q93084
Ensembl - ENSG00000074370
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp2a3ENSDARG00000060978Danio rerio
 ATP2A3ENSGALG00000001564Gallus gallus
 Atp2a3ENSMUSG00000020788Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ATP2A2 / P16615 / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2ENSG0000017443773
ATP2A1 / O14983 / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1ENSG0000019629672
ATP2C1 / P98194 / ATPase secretory pathway Ca2+ transporting 1ENSG0000001726031
ATP2C2 / O75185 / ATPase secretory pathway Ca2+ transporting 2ENSG0000006427030
ATP1A2 / P50993 / ATPase Na+/K+ transporting subunit alpha 2ENSG0000001862529
ATP1A4 / Q13733 / ATPase Na+/K+ transporting subunit alpha 4ENSG0000013268128
AC010616.2ENSG0000028550528
ATP1A1 / P05023 / ATPase Na+/K+ transporting subunit alpha 1ENSG0000016339928
ATP4A / P20648 / ATPase H+/K+ transporting alpha subunitENSG0000010567528
ATP1A3 / P13637 / ATPase Na+/K+ transporting subunit alpha 3ENSG0000010540928
ATP12A / P54707 / ATPase H+/K+ transporting non-gastric alpha2 subunitENSG0000007567327


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR004014  Cation-transporting P-type ATPase, N-terminal
 IPR005782  P-type ATPase, subfamily IIA, SERCA-type
 IPR006068  Cation-transporting P-type ATPase, C-terminal
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR023214  HAD superfamily
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR030330  Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport TAS
 biological_processGO:0034220 ion transmembrane transport TAS
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0099132 ATP hydrolysis coupled cation transmembrane transport IEA
 biological_processGO:1903779 regulation of cardiac conduction TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum IEA
 cellular_componentGO:0031095 platelet dense tubular network membrane TAS
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005388 calcium-transporting ATPase activity TAS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Pre-NOTCH Processing in Golgi
Reduction of cytosolic Ca++ levels
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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