ENSG00000105675


Homo sapiens

Features
Gene ID: ENSG00000105675
  
Biological name :ATP4A
  
Synonyms : ATP4A / ATPase H+/K+ transporting alpha subunit / P20648
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.12
Gene start: 35550043
Gene end: 35563658
  
Corresponding Affymetrix probe sets: 207139_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262623
Ensembl peptide - ENSP00000472323
NCBI entrez gene - 495     See in Manteia.
OMIM - 137216
RefSeq - NM_000704
RefSeq Peptide - NP_000695
swissprot - P20648
swissprot - M0R249
Ensembl - ENSG00000105675
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Atp4aENSMUSG00000005553Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ATP12A / P54707 / ATPase H+/K+ transporting non-gastric alpha2 subunitENSG0000007567364
ATP1A3 / P13637 / ATPase Na+/K+ transporting subunit alpha 3ENSG0000010540964
AC010616.2ENSG0000028550563
ATP1A1 / P05023 / ATPase Na+/K+ transporting subunit alpha 1ENSG0000016339962
ATP1A2 / P50993 / ATPase Na+/K+ transporting subunit alpha 2ENSG0000001862562
ATP1A4 / Q13733 / ATPase Na+/K+ transporting subunit alpha 4ENSG0000013268159
ATP2A3 / Q93084 / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3ENSG0000007437029
ATP2A1 / O14983 / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1ENSG0000019629628
ATP2A2 / P16615 / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2ENSG0000017443728
ATP2C2 / O75185 / ATPase secretory pathway Ca2+ transporting 2ENSG0000006427027
ATP2C1 / P98194 / ATPase secretory pathway Ca2+ transporting 1ENSG0000001726026


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR004014  Cation-transporting P-type ATPase, N-terminal
 IPR005775  P-type ATPase subfamily IIC, subunit alpha
 IPR006068  Cation-transporting P-type ATPase, C-terminal
 IPR008250  P-type ATPase, A domain superfamily
 IPR015127  Gastric H+/K+-transporter P-type ATPase, N-terminal
 IPR018303  P-type ATPase, phosphorylation site
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0010248 establishment or maintenance of transmembrane electrochemical gradient IEA
 biological_processGO:0015991 ATP hydrolysis coupled proton transport IEA
 biological_processGO:0034220 ion transmembrane transport TAS
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0005391 sodium:potassium-exchanging ATPase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008900 potassium:proton exchanging ATPase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000186009 ATP4B / P51164 / ATPase H+/K+ transporting beta subunit  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr