ENSG00000075673


Homo sapiens

Features
Gene ID: ENSG00000075673
  
Biological name :ATP12A
  
Synonyms : ATP12A / ATPase H+/K+ transporting non-gastric alpha2 subunit / P54707
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: 1
Band: q12.12
Gene start: 24680411
Gene end: 24712493
  
Corresponding Affymetrix probe sets: 207367_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000218548
Ensembl peptide - ENSP00000371372
NCBI entrez gene - 479     See in Manteia.
OMIM - 182360
RefSeq - NM_001185085
RefSeq - NM_001676
RefSeq Peptide - NP_001172014
RefSeq Peptide - NP_001667
swissprot - P54707
Ensembl - ENSG00000075673
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ATP12AENSGALG00000006469Gallus gallus
 Atp12aENSMUSG00000022229Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ATP4A / P20648 / ATPase H+/K+ transporting alpha subunitENSG0000010567564
ATP1A1 / P05023 / ATPase Na+/K+ transporting subunit alpha 1ENSG0000016339963
ATP1A2 / P50993 / ATPase Na+/K+ transporting subunit alpha 2ENSG0000001862563
ATP1A3 / P13637 / ATPase Na+/K+ transporting subunit alpha 3ENSG0000010540963
AC010616.2ENSG0000028550562
ATP1A4 / Q13733 / ATPase Na+/K+ transporting subunit alpha 4ENSG0000013268160
ATP2A3 / Q93084 / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3ENSG0000007437027
ATP2A2 / P16615 / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2ENSG0000017443727
ATP2A1 / O14983 / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1ENSG0000019629626
ATP2C2 / O75185 / ATPase secretory pathway Ca2+ transporting 2ENSG0000006427025
ATP2C1 / P98194 / ATPase secretory pathway Ca2+ transporting 1ENSG0000001726024


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR004014  Cation-transporting P-type ATPase, N-terminal
 IPR005775  P-type ATPase subfamily IIC, subunit alpha
 IPR006068  Cation-transporting P-type ATPase, C-terminal
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR030318  Potassium-transporting ATPase alpha chain 2
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006885 regulation of pH IEA
 biological_processGO:0010248 establishment or maintenance of transmembrane electrochemical gradient IEA
 biological_processGO:0034220 ion transmembrane transport TAS
 biological_processGO:0055075 potassium ion homeostasis IEA
 biological_processGO:0099132 ATP hydrolysis coupled cation transmembrane transport IEA
 biological_processGO:1902600 proton transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005889 potassium:proton exchanging ATPase complex TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005391 sodium:potassium-exchanging ATPase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008900 potassium:proton exchanging ATPase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019829 cation-transporting ATPase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000186009 ATP4B / P51164 / ATPase H+/K+ transporting beta subunit  / complex






 

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