ENSMUSG00000031449


Mus musculus

Features
Gene ID: ENSMUSG00000031449
  
Biological name :Atp4b
  
Synonyms : Atp4b / P50992 / Potassium-transporting ATPase subunit beta
  
Possible biological names infered from orthology : ATPase H+/K+ transporting beta subunit / P51164
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A1.1
Gene start: 13386205
Gene end: 13396825
  
Corresponding Affymetrix probe sets: 10577154 (MoGene1.0st)   1448911_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033826
NCBI entrez gene - 11945     See in Manteia.
MGI - MGI:88114
RefSeq - NM_009724
RefSeq Peptide - NP_033854
swissprot - P50992
swissprot - Q0VBB6
Ensembl - ENSMUSG00000031449
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ATP4BENSGALG00000016822Gallus gallus
 ATP4BENSG00000186009Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atp1b2 / P14231 / Sodium/potassium-transporting ATPase subunit beta-2 / P14415* / ATPase Na+/K+ transporting subunit beta 2*ENSMUSG0000004132938
Atp1b4 / Q99ME6 / Protein ATP1B4 / Q9UN42* / ATPase Na+/K+ transporting family member beta 4*ENSMUSG0000001632733
Atp1b3 / P97370 / Sodium/potassium-transporting ATPase subunit beta-3 / P54709* / ATPase Na+/K+ transporting subunit beta 3*ENSMUSG0000003241231
Atp1b1 / P14094 / Sodium/potassium-transporting ATPase subunit beta-1 / P05026* / ATPase Na+/K+ transporting subunit beta 1*ENSMUSG0000002657630


Protein motifs (from Interpro)
Interpro ID Name
 IPR000402  Sodium/potassium-transporting ATPase subunit beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0010155 regulation of proton transport ISO
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0033577 protein glycosylation in endoplasmic reticulum ISO
 biological_processGO:0045851 pH reduction ISO
 biological_processGO:1902600 proton transmembrane transport IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005890 sodium:potassium-exchanging ATPase complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008900 potassium:proton exchanging ATPase activity ISO
 molecular_functionGO:0046982 protein heterodimerization activity ISO


Pathways (from Reactome)
Pathway description
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003892 abnormal gastric gland "anomaly of any of the branched tubular glands in the mucosa of the fundus and body of the stomach that contain parietal cells that secrete hydrocholric acid and zymogenic cells that produce pepsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

Allelic Composition: Atp4btm1Ird/Atp4btm1Ird,Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cCrSlc

 MP:0004139 abnormal parietal cell morphology "malformation of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

Allelic Composition: Atp4btm1Ird/Atp4btm1Ird,Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cCrSlc

 MP:0004140 abnormal chief cell morphology "malformation of the pepsinogen producing epithelial cells that are clustered at the base of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

Allelic Composition: Atp4btm1Ird/Atp4btm1Ird,Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cCrSlc

 MP:0004731 increased circulating gastrin level "greater concentration in the blood of polypeptide hormones secreted by the pyloric-antral mucous lining of the stomach that induces the secretion of gastric juice by the parietal cells of the gastric glands; they also occur in the central nervous system where they are presumed to be neurotransmitters" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

 MP:0005211 increased thickness of gastric mucosa "greater than the normal depth or width of the epithelial layer of the stomach" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:77398]
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Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

 MP:0008006 increased stomach pH "change in the function of the secretory and buffer systems of the stomach that control the relative acidity or alkalinity, such that the acidity is decreased, as indicated by the decreased concentration of hydrogen ion" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

 MP:0010792 abnormal stomach mucosa morphology "any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

Allelic Composition: Atp4btm1Ird/Atp4btm1Ird,Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cCrSlc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005553 Atp4a / ATPase H+/K+ transporting alpha subunit / P20648*  / complex
 ENSMUSG00000022229 Atp12a / Q9Z1W8 / Potassium-transporting ATPase alpha chain 2 / P54707* / ATPase H+/K+ transporting non-gastric alpha2 subunit*  / complex






 

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