ENSG00000143153


Homo sapiens

Features
Gene ID: ENSG00000143153
  
Biological name :ATP1B1
  
Synonyms : ATP1B1 / ATPase Na+/K+ transporting subunit beta 1 / P05026
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q24.2
Gene start: 169105697
Gene end: 169132722
  
Corresponding Affymetrix probe sets: 201242_s_at (Human Genome U133 Plus 2.0 Array)   201243_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000356790
Ensembl peptide - ENSP00000477015
Ensembl peptide - ENSP00000356789
NCBI entrez gene - 481     See in Manteia.
OMIM - 182330
RefSeq - NM_001677
RefSeq Peptide - NP_001668
swissprot - A3KLL5
swissprot - P05026
swissprot - V9GYR2
Ensembl - ENSG00000143153
  
Related genetic diseases (OMIM): 145500 - [Blood pressure regulation QTL], 145500
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp1b1aENSDARG00000013144Danio rerio
 atp1b1bENSDARG00000076833Danio rerio
 ATP1B1ENSGALG00000015233Gallus gallus
 Atp1b1ENSMUSG00000026576Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ATP1B2 / P14415 / ATPase Na+/K+ transporting subunit beta 2ENSG0000012924438
ATP1B3 / P54709 / ATPase Na+/K+ transporting subunit beta 3ENSG0000006984934
ATP1B4 / Q9UN42 / ATPase Na+/K+ transporting family member beta 4ENSG0000010189232
ATP4B / P51164 / ATPase H+/K+ transporting beta subunitENSG0000018600928


Protein motifs (from Interpro)
Interpro ID Name
 IPR000402  Sodium/potassium-transporting ATPase subunit beta
 IPR015565  Sodium/potassium-transporting ATPase subunit beta, chordates


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis ISS
 biological_processGO:0006883 cellular sodium ion homeostasis IDA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0010107 potassium ion import IDA
 biological_processGO:0010248 establishment or maintenance of transmembrane electrochemical gradient IEA
 biological_processGO:0010468 regulation of gene expression ISS
 biological_processGO:0010882 regulation of cardiac muscle contraction by calcium ion signaling ISS
 biological_processGO:0030001 metal ion transport IEA
 biological_processGO:0030007 cellular potassium ion homeostasis IDA
 biological_processGO:0032781 positive regulation of ATPase activity IDA
 biological_processGO:0034220 ion transmembrane transport TAS
 biological_processGO:0036376 sodium ion export across plasma membrane ISS
 biological_processGO:0044861 protein transport into plasma membrane raft TAS
 biological_processGO:0046034 ATP metabolic process IDA
 biological_processGO:0050821 protein stabilization ISS
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0055119 relaxation of cardiac muscle ISS
 biological_processGO:0060048 cardiac muscle contraction ISS
 biological_processGO:0072659 protein localization to plasma membrane IDA
 biological_processGO:0086009 membrane repolarization IDA
 biological_processGO:0086013 membrane repolarization during cardiac muscle cell action potential IC
 biological_processGO:0086064 cell communication by electrical coupling involved in cardiac conduction TAS
 biological_processGO:1901018 positive regulation of potassium ion transmembrane transporter activity IDA
 biological_processGO:1903169 regulation of calcium ion transmembrane transport IEA
 biological_processGO:1903278 positive regulation of sodium ion export across plasma membrane IDA
 biological_processGO:1903281 positive regulation of calcium:sodium antiporter activity ISS
 biological_processGO:1903288 positive regulation of potassium ion import IDA
 biological_processGO:1903779 regulation of cardiac conduction TAS
 biological_processGO:1990573 potassium ion import across plasma membrane ISS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005890 sodium:potassium-exchanging ATPase complex IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0014704 intercalated disc ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0042383 sarcolemma ISS
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1903561 extracellular vesicle HDA
 molecular_functionGO:0001671 ATPase activator activity IDA
 molecular_functionGO:0005391 sodium:potassium-exchanging ATPase activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008144 drug binding IPI
 molecular_functionGO:0016887 ATPase activity IDA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0023026 MHC class II protein complex binding HDA
 molecular_functionGO:0030955 potassium ion binding IDA
 molecular_functionGO:0031402 sodium ion binding IDA
 molecular_functionGO:0051117 ATPase binding IPI


Pathways (from Reactome)
Pathway description
Basigin interactions
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000129244 ATP1B2 / P14415 / ATPase Na+/K+ transporting subunit beta 2  / complex
 ENSG00000069849 ATP1B3 / P54709 / ATPase Na+/K+ transporting subunit beta 3  / complex
 ENSG00000105409 ATP1A3 / P13637 / ATPase Na+/K+ transporting subunit alpha 3  / complex
 ENSG00000163399 ATP1A1 / P05023 / ATPase Na+/K+ transporting subunit alpha 1  / complex
 ENSG00000018625 ATP1A2 / P50993 / ATPase Na+/K+ transporting subunit alpha 2  / complex
 ENSG00000172270 BSG / P35613 / basigin (Ok blood group)  / reaction / complex
 ENSG00000132681 ATP1A4 / Q13733 / ATPase Na+/K+ transporting subunit alpha 4  / complex






 

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