ENSMUSG00000051457


Mus musculus

Features
Gene ID: ENSMUSG00000051457
  
Biological name :Spn
  
Synonyms : P15702 / sialophorin / Spn
  
Possible biological names infered from orthology : P16150
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F3
Gene start: 127132232
Gene end: 127137823
  
Corresponding Affymetrix probe sets: 10568174 (MoGene1.0st)   1422133_at (Mouse Genome 430 2.0 Array)   1439034_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000049534
Ensembl peptide - ENSMUSP00000122787
Ensembl peptide - ENSMUSP00000145637
NCBI entrez gene - 20737     See in Manteia.
MGI - MGI:98384
RefSeq - XM_011241716
RefSeq - NM_001037810
RefSeq - NM_009259
RefSeq - XM_006507522
RefSeq Peptide - NP_033285
RefSeq Peptide - NP_001032899
swissprot - P15702
swissprot - Q544C5
swissprot - A0A0U1RNN5
Ensembl - ENSMUSG00000051457
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SPNENSG00000197471Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001562 response to protozoan IDA
 biological_processGO:0001808 negative regulation of type IV hypersensitivity IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IGI
 biological_processGO:0002296 T-helper 1 cell lineage commitment ISS
 biological_processGO:0007162 negative regulation of cell adhesion IMP
 biological_processGO:0007166 cell surface receptor signaling pathway IDA
 biological_processGO:0031295 T cell costimulation IDA
 biological_processGO:0032609 interferon-gamma production ISS
 biological_processGO:0042102 positive regulation of T cell proliferation IDA
 biological_processGO:0042130 negative regulation of T cell proliferation IMP
 biological_processGO:0042535 positive regulation of tumor necrosis factor biosynthetic process ISO
 biological_processGO:0042742 defense response to bacterium ISO
 biological_processGO:0045060 negative thymic T cell selection IMP
 biological_processGO:0050688 regulation of defense response to virus IMP
 biological_processGO:0050776 regulation of immune response IMP
 biological_processGO:0050868 negative regulation of T cell activation IMP
 biological_processGO:0050901 leukocyte tethering or rolling IMP
 biological_processGO:0097190 apoptotic signaling pathway IDA
 biological_processGO:2000404 regulation of T cell migration IMP
 biological_processGO:2000406 positive regulation of T cell migration IMP
 cellular_componentGO:0001931 uropod IEA
 cellular_componentGO:0005604 basement membrane IDA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0005902 microvillus ISS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030544 Hsp70 protein binding ISO
 molecular_functionGO:0031072 heat shock protein binding IPI


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
Basigin interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ripk2tm1Ghc/Ripk2tm1Ghc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ripk2tm1Ghc/Ripk2tm1Ghc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ripk2tm1Ghc/Ripk2tm1Ghc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ripk2tm1Ghc/Ripk2tm1Ghc
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026582 Sele / selectin, endothelial cell / P16581* / selectin E*  / reaction / complex
 ENSMUSG00000023175 Bsg / P18572 / Basigin / P35613* / basigin (Ok blood group)*  / reaction / complex
 ENSMUSG00000003316 Glg1 / Q61543 / Golgi apparatus protein 1 / Q92896* / golgi glycoprotein 1*  / reaction / complex
 ENSMUSG00000051457 Spn / P15702 / sialophorin / P16150*  / reaction / complex






 

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