Manteia - Molecule gene

ENSMUSG00000003316

Mus musculus

Features

Gene ID:	ENSMUSG00000003316

Biological name :	Glg1

Synonyms :	Glg1 / Golgi apparatus protein 1 / Q61543

Possible biological names infered from orthology :	golgi glycoprotein 1 / Q92896

Species:	Mus musculus

Chr. number:	8
Strand:	-1
Band:	E1
Gene start:	111154421
Gene end:	111259216

Corresponding Affymetrix probe sets:	10581772 (MoGene1.0st) 1417087_at (Mouse Genome 430 2.0 Array) 1448579_at (Mouse Genome 430 2.0 Array) 1448580_at (Mouse Genome 430 2.0 Array) 1460554_s_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000131659 Ensembl peptide - ENSMUSP00000130327 Ensembl peptide - ENSMUSP00000003404 Ensembl peptide - ENSMUSP00000131355 NCBI entrez gene - 20340 See in Manteia. MGI - MGI:104967 RefSeq - NM_009149 RefSeq Peptide - NP_033175 swissprot - Q61543 swissprot - E9PWD8 swissprot - F6RSH1 swissprot - F8WHM5 swissprot - Q53WR6 Ensembl - ENSMUSG00000003316

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
glg1a	ENSDARG00000061282	Danio rerio
glg1b	ENSDARG00000101210	Danio rerio
GLG1	ENSGALG00000039818	Gallus gallus
GLG1	ENSG00000090863	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR001893	Cysteine-rich Golgi apparatus protein 1 repeat
IPR015943	WD40/YVTN repeat-like-containing domain superfamily
IPR017873	Cysteine-rich Golgi apparatus protein 1 repeat, eukaryote

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0010955	negative regulation of protein processing	IMP
biological_process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	IMP
biological_process	GO:0032330	regulation of chondrocyte differentiation	IMP
biological_process	GO:0060349	bone morphogenesis	IMP
cellular_component	GO:0000139	Golgi membrane	IEA
cellular_component	GO:0005794	Golgi apparatus	ISO
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0017134	fibroblast growth factor binding	IBA
molecular_function	GO:0030246	carbohydrate binding	IEA

Pathways (from Reactome)

Pathway description

Cell surface interactions at the vascular wall

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000111	cleft palate	"congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Brca2^tm1Cbl/Brca2^tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
MP:0000150	abnormal rib morphology	"malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]	Show Allelic Composition: Fgf18^tm1Sjt/Fgf18^tm1Sjt,Glg1^{Gt(KST005)Byg}/Glg1^{Gt(KST005)Byg} Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt Allelic Composition: Fgf18^tm1Sjt/Fgf18^tm1Sjt,Glg1^{Gt(KST005)Byg}/Glg1⁺ Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Brca2^tm1Cbl/Brca2^tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2) Allelic Composition: Fgf18^tm1Sjt/Fgf18⁺,Glg1^{Gt(KST005)Byg}/Glg1⁺ Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Brca2^tm1Cbl/Brca2^tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2) Allelic Composition: Glg1^tm1Brle/Glg1^tm1Brle Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Fgfr3^tm1Led/Fgfr3^tm1Led,Glg1^tm1Brle/Glg1^tm1Brle Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J
MP:0001533	abnormal skeleton physiology	"anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Myh9^{tm4(GFP/MYH10/MYH9)Rsad}/Myh9^{tm4(GFP/MYH10/MYH9)Rsad} Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002111	abnormal tail morphology	"abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Brca2^tm1Cbl/Brca2^tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2) Allelic Composition: Fgf18^tm1Sjt/Fgf18⁺,Glg1^{Gt(KST005)Byg}/Glg1⁺ Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt Allelic Composition: Fgf18^tm1Sjt/Fgf18^tm1Sjt,Glg1^{Gt(KST005)Byg}/Glg1^{Gt(KST005)Byg} Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt Allelic Composition: Fgf18^tm1Sjt/Fgf18⁺,Glg1^{Gt(KST005)Byg}/Glg1^{Gt(KST005)Byg} Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt
MP:0002759	abnormal caudal vertebrae morphology	"malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]	Show Allelic Composition: Brca2^tm1Cbl/Brca2^tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
MP:0003131	increased erythrocyte count	"greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1⁺ Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0003443	increased circulating glycerol level	"higher than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1⁺ Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0003628	abnormal lymphocyte adhesion	"anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]	Show Allelic Composition: Eomes^tm1.1Twa/?,Tg(CD2-Tbx21)#Staka/? Genetic Background: involves: C57BL/6N
MP:0003795	abnormal bone structure		Show Allelic Composition: Glg1^tm1Brle/Glg1^tm1Brle Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0003799	impaired macrophage migration	"defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Glg1^{Gt(RST092)Byg}/Glg1⁺ Genetic Background: B6J.129P2-Apoe^tm1Unc Glg1^{Gt(RST092)Byg}
MP:0003884	decreased macrophage count	"fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Glg1^{Gt(RST092)Byg}/Glg1⁺ Genetic Background: B6J.129P2-Apoe^tm1Unc Glg1^{Gt(RST092)Byg}
MP:0004173	abnormal intervertebral disk morphology	"malformation of the cartilagenous and gelatinous structure found between vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Brca2^tm1Cbl/Brca2^tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
MP:0004174	abnormal spine curvature	"deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf18^tm1Sjt/Fgf18^tm1Sjt,Glg1^{Gt(KST005)Byg}/Glg1^{Gt(KST005)Byg} Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt Allelic Composition: Fgf18^tm1Sjt/Fgf18^tm1Sjt,Glg1^{Gt(KST005)Byg}/Glg1⁺ Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt
MP:0004200	reduced fetal size	"smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca2^tm1Cbl/Brca2^tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2) Allelic Composition: Glg1^tm1Brle/Glg1^tm1Brle Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0004538	abnormal maxillary shelf	"any structural anomaly of the outgrowth of the maxilla that normally fuses with palatine shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca2^tm1Cbl/Brca2^tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
MP:0005338	atherosclerotic lesions	"thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Eomes^tm1.1Twa/?,Tg(CD2-Tbx21)#Staka/? Genetic Background: involves: C57BL/6N
MP:0005477	increased circulating thyroxine level	"greater than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1⁺ Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0005508	abnormal skeleton morphology	"malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf18^tm1Sjt/Fgf18⁺,Glg1^{Gt(KST005)Byg}/Glg1^{Gt(KST005)Byg} Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt
MP:0006396	decreased long bone epiphyseal plate size	"reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Glg1^tm1Brle/Glg1^tm1Brle Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Fgfr3^tm1Led/Fgfr3^tm1Led,Glg1^tm1Brle/Glg1^tm1Brle Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J
MP:0008770	decreased survivor rate	"a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca2^tm1Cbl/Brca2^tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
MP:0009247	meteorism	"swelling of the abdomen resulting from gas in the intestinal or peritoneal cavity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca2^tm1Cbl/Brca2^tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
MP:0009431	decreased fetal weight	"reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Brca2^tm1Cbl/Brca2^tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)
MP:0009703	decreased birth body size	"reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Glg1^tm1Brle/Glg1^tm1Brle Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0009780	abnormal chondrocyte physiology	"any functional anomaly of nondividing cartilage cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Glg1^tm1Brle/Glg1^tm1Brle Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0009858	abnormal cellular extravasation	"any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]	Show Allelic Composition: Eomes^tm1.1Twa/?,Tg(CD2-Tbx21)#Staka/? Genetic Background: involves: C57BL/6N
MP:0010103	small thoracic cage	"reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Glg1^tm1Brle/Glg1^tm1Brle Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Brca2^tm1Cbl/Brca2^tm1Cbl Genetic Background: either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2) Allelic Composition: Fgf18^tm1Sjt/Fgf18⁺,Glg1^{Gt(KST005)Byg}/Glg1^{Gt(KST005)Byg} Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Fgf18^tm1Sjt/Fgf18^tm1Sjt,Glg1^{Gt(KST005)Byg}/Glg1^{Gt(KST005)Byg} Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt Allelic Composition: Fgf18^tm1Sjt/Fgf18^tm1Sjt,Glg1^{Gt(KST005)Byg}/Glg1⁺ Genetic Background: B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt
MP:0011092	complete embryonic lethality	"death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Eomes^tm1.1Twa/?,Tg(CD2-Tbx21)#Staka/? Genetic Background: involves: C57BL/6N
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Foxo3^{tm1.1(KOMP)Vlcg}/Foxo3^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Foxo3^{tm1.1(KOMP)Vlcg}/J
MP:0020253	increased collagen level	"increased level of the main structural protein of the various connective tissues in animals" [GOC:NV, PMID:11704682]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Glg1^{Gt(RST092)Byg}/Glg1⁺ Genetic Background: B6J.129P2-Apoe^tm1Unc Glg1^{Gt(RST092)Byg}
MP:0020333	enhanced leukocyte tethering or rolling	"enhancement of the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]	Show Allelic Composition: Eomes^tm1.1Twa/?,Tg(CD2-Tbx21)#Staka/? Genetic Background: involves: C57BL/6N

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000003316	Glg1 / Q61543 / Golgi apparatus protein 1 / Q92896* / golgi glycoprotein 1*	/ reaction / complex
ENSMUSG00000026582	Sele / selectin, endothelial cell / P16581* / selectin E*	/ reaction / complex
ENSMUSG00000051457	Spn / P15702 / sialophorin / P16150*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr