Manteia

ENSMUSG00000074991

Mus musculus

Features

Gene ID:	ENSMUSG00000074991

Biological name :	Gabrr3

Synonyms :	Gabrr3 / gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene)

Possible biological names infered from orthology :	A8MPY1

Species:	Mus musculus

Chr. number:	16
Strand:	1
Band:	C1.3
Gene start:	59407332
Gene end:	59461889

Corresponding Affymetrix probe sets:	10436416 (MoGene1.0st)

Cross references:	Ensembl peptide - ENSMUSP00000109980 NCBI entrez gene - 328699 See in Manteia. MGI - MGI:3588203 RefSeq - NM_001081190 RefSeq Peptide - NP_001074659 swissprot - B2RXA8 Ensembl - ENSMUSG00000074991

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
gabrr3a	ENSDARG00000027153	Danio rerio
gabrr3b	ENSDARG00000030750	Danio rerio
GABRR3	ENSGALG00000035787	Gallus gallus
A8MPY1	ENSG00000183185	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Gabrr1 / P56475 / Gamma-aminobutyric acid receptor subunit rho-1 / P24046* / gamma-aminobutyric acid type A receptor rho1 subunit*	ENSMUSG00000028280	60
Gabrr2 / P56476 / Gamma-aminobutyric acid receptor subunit rho-2 / P28476* / gamma-aminobutyric acid type A receptor rho2 subunit*	ENSMUSG00000023267	59
Gabrb3 / P63080 / Gamma-aminobutyric acid receptor subunit beta-3 / P28472* / gamma-aminobutyric acid type A receptor beta3 subunit*	ENSMUSG00000033676	36
Gabrb1 / P50571 / Gamma-aminobutyric acid receptor subunit beta-1 / P18505* / gamma-aminobutyric acid type A receptor beta1 subunit*	ENSMUSG00000029212	35
Gabrb2 / P63137 / Gamma-aminobutyric acid receptor subunit beta-2 / P47870* / gamma-aminobutyric acid type A receptor beta2 subunit*	ENSMUSG00000007653	35
Gabrd / P22933 / Gamma-aminobutyric acid receptor subunit delta / O14764* / gamma-aminobutyric acid type A receptor delta subunit*	ENSMUSG00000029054	32
Gabrp / Q8QZW7 / Gamma-aminobutyric acid receptor subunit pi / O00591* / gamma-aminobutyric acid type A receptor pi subunit*	ENSMUSG00000020159	31
Glra3 / glycine receptor alpha 3 / O75311*	ENSMUSG00000038257	31
Glra4 / Q61603 / Glycine receptor subunit alpha-4 / Q5JXX5* / glycine receptor alpha 4*	ENSMUSG00000018595	31
Glra1 / Q64018 / Glycine receptor subunit alpha-1 / P23415* / glycine receptor alpha 1*	ENSMUSG00000000263	30
Gabrq / Q9JLF1 / Gamma-aminobutyric acid receptor subunit theta / Q9UN88* / gamma-aminobutyric acid type A receptor theta subunit*	ENSMUSG00000031344	30
Glra2 / Q7TNC8 / Mus musculus glycine receptor, alpha 2 subunit (Glra2), transcript variant 3, mRNA. / P23416* / glycine receptor alpha 2*	ENSMUSG00000018589	30
Glrb / P48168 / Glycine receptor subunit beta / P48167* / glycine receptor beta*	ENSMUSG00000028020	29

Protein motifs (from Interpro)

Interpro ID	Name
IPR006028	Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
IPR006201	Neurotransmitter-gated ion-channel
IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain
IPR018000	Neurotransmitter-gated ion-channel, conserved site
IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily
IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006811	ion transport	IEA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0034220	ion transmembrane transport	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:1902711	GABA-A receptor complex	IBA
molecular_function	GO:0004888	transmembrane signaling receptor activity	IEA
molecular_function	GO:0004890	GABA-A receptor activity	IBA
molecular_function	GO:0005216	ion channel activity	IEA
molecular_function	GO:0005230	extracellular ligand-gated ion channel activity	IEA
molecular_function	GO:0019904	protein domain specific binding	IEA

Pathways (from Reactome)

Pathway description

GABA A (rho) receptor activation

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000028280	Gabrr1 / P56475 / Gamma-aminobutyric acid receptor subunit rho-1 / P24046* / gamma-aminobutyric acid type A receptor rho1 subunit*	/ complex
ENSMUSG00000023267	Gabrr2 / P56476 / Gamma-aminobutyric acid receptor subunit rho-2 / P28476* / gamma-aminobutyric acid type A receptor rho2 subunit*	/ complex
ENSMUSG00000074991	Gabrr3 / gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene) / A8MPY1*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr