Manteia

ENSMUSG00000018595

Mus musculus

Features

Gene ID:	ENSMUSG00000018595

Biological name :	Glra4

Synonyms :	Glra4 / Glycine receptor subunit alpha-4 / Q61603

Possible biological names infered from orthology :	glycine receptor alpha 4 / Q5JXX5

Species:	Mus musculus

Chr. number:	X
Strand:	-1
Band:	F1
Gene start:	136757674
Gene end:	136780141

Corresponding Affymetrix probe sets:	10606880 (MoGene1.0st) 1451937_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000018739 NCBI entrez gene - 14657 See in Manteia. MGI - MGI:95750 RefSeq - NM_010297 RefSeq - XM_017318384 RefSeq Peptide - NP_034427 swissprot - Q61603 Ensembl - ENSMUSG00000018595

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
glra4a	ENSDARG00000006865	Danio rerio
glra4b	ENSDARG00000058103	Danio rerio
GLRA4	ENSGALG00000004936	Gallus gallus
GLRA4	ENSG00000188828	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Glra2 / Q7TNC8 / Mus musculus glycine receptor, alpha 2 subunit (Glra2), transcript variant 3, mRNA. / P23416* / glycine receptor alpha 2*	ENSMUSG00000018589	79
Glra3 / glycine receptor alpha 3 / O75311*	ENSMUSG00000038257	78
Glra1 / Q64018 / Glycine receptor subunit alpha-1 / P23415* / glycine receptor alpha 1*	ENSMUSG00000000263	74
Glrb / P48168 / Glycine receptor subunit beta / P48167* / glycine receptor beta*	ENSMUSG00000028020	47
Gabrb2 / P63137 / Gamma-aminobutyric acid receptor subunit beta-2 / P47870* / gamma-aminobutyric acid type A receptor beta2 subunit*	ENSMUSG00000007653	37
Gabrb3 / P63080 / Gamma-aminobutyric acid receptor subunit beta-3 / P28472* / gamma-aminobutyric acid type A receptor beta3 subunit*	ENSMUSG00000033676	37
Gabrb1 / P50571 / Gamma-aminobutyric acid receptor subunit beta-1 / P18505* / gamma-aminobutyric acid type A receptor beta1 subunit*	ENSMUSG00000029212	37
Gabrd / P22933 / Gamma-aminobutyric acid receptor subunit delta / O14764* / gamma-aminobutyric acid type A receptor delta subunit*	ENSMUSG00000029054	33
Gabrq / Q9JLF1 / Gamma-aminobutyric acid receptor subunit theta / Q9UN88* / gamma-aminobutyric acid type A receptor theta subunit*	ENSMUSG00000031344	33
Gabrr2 / P56476 / Gamma-aminobutyric acid receptor subunit rho-2 / P28476* / gamma-aminobutyric acid type A receptor rho2 subunit*	ENSMUSG00000023267	32
Gabrr1 / P56475 / Gamma-aminobutyric acid receptor subunit rho-1 / P24046* / gamma-aminobutyric acid type A receptor rho1 subunit*	ENSMUSG00000028280	31
Gabrr3 / gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene) / A8MPY1*	ENSMUSG00000074991	31
Gabrp / Q8QZW7 / Gamma-aminobutyric acid receptor subunit pi / O00591* / gamma-aminobutyric acid type A receptor pi subunit*	ENSMUSG00000020159	31

Protein motifs (from Interpro)

Interpro ID	Name
IPR006028	Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
IPR006201	Neurotransmitter-gated ion-channel
IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain
IPR008127	Glycine receptor alpha
IPR018000	Neurotransmitter-gated ion-channel, conserved site
IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily
IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006811	ion transport	IEA
biological_process	GO:0006821	chloride transport	IEA
biological_process	GO:0007218	neuropeptide signaling pathway	IBA
biological_process	GO:0034220	ion transmembrane transport	IEA
biological_process	GO:0043200	response to amino acid	IDA
biological_process	GO:0060012	synaptic transmission, glycinergic	IBA
biological_process	GO:0060079	excitatory postsynaptic potential	IEA
biological_process	GO:1902476	chloride transmembrane transport	IDA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0005887	integral component of plasma membrane	IDA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0030054	cell junction	IEA
cellular_component	GO:0030425	dendrite	IEA
cellular_component	GO:0034707	chloride channel complex	IEA
cellular_component	GO:0042995	cell projection	IEA
cellular_component	GO:0043204	perikaryon	IEA
cellular_component	GO:0045202	synapse	IEA
cellular_component	GO:0045211	postsynaptic membrane	IEA
molecular_function	GO:0004888	transmembrane signaling receptor activity	IEA
molecular_function	GO:0005216	ion channel activity	IEA
molecular_function	GO:0005230	extracellular ligand-gated ion channel activity	IEA
molecular_function	GO:0005254	chloride channel activity	IEA
molecular_function	GO:0016594	glycine binding	IBA
molecular_function	GO:0016934	extracellularly glycine-gated chloride channel activity	IDA
molecular_function	GO:0022824	transmitter-gated ion channel activity	IEA

Pathways (from Reactome)

Pathway description

Neurotransmitter receptors and postsynaptic signal transmission

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr