ENSMUSG00000007653


Mus musculus

Features
Gene ID: ENSMUSG00000007653
  
Biological name :Gabrb2
  
Synonyms : Gabrb2 / Gamma-aminobutyric acid receptor subunit beta-2 / P63137
  
Possible biological names infered from orthology : gamma-aminobutyric acid type A receptor beta2 subunit / P47870
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A5
Gene start: 42419757
Gene end: 42629028
  
Corresponding Affymetrix probe sets: 10375245 (MoGene1.0st)   1428203_at (Mouse Genome 430 2.0 Array)   1428204_at (Mouse Genome 430 2.0 Array)   1428205_x_at (Mouse Genome 430 2.0 Array)   1429685_at (Mouse Genome 430 2.0 Array)   1450319_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000007797
Ensembl peptide - ENSMUSP00000141868
NCBI entrez gene - 14401     See in Manteia.
MGI - MGI:95620
RefSeq - XM_017314261
RefSeq - NM_008070
RefSeq - XM_011248726
RefSeq Peptide - NP_001334243
RefSeq Peptide - NP_032096
swissprot - P63137
Ensembl - ENSMUSG00000007653
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gabrb2ENSDARG00000079586Danio rerio
 GABRB2 (1 of many)ENSDARG00000100032Danio rerio
 GABRB2ENSGALG00000001690Gallus gallus
 GABRB2ENSG00000145864Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gabrb1 / P50571 / Gamma-aminobutyric acid receptor subunit beta-1 / P18505* / gamma-aminobutyric acid type A receptor beta1 subunit*ENSMUSG0000002921280
Gabrb3 / P63080 / Gamma-aminobutyric acid receptor subunit beta-3 / P28472* / gamma-aminobutyric acid type A receptor beta3 subunit*ENSMUSG0000003367677
Gabrq / Q9JLF1 / Gamma-aminobutyric acid receptor subunit theta / Q9UN88* / gamma-aminobutyric acid type A receptor theta subunit*ENSMUSG0000003134442
Gabrr1 / P56475 / Gamma-aminobutyric acid receptor subunit rho-1 / P24046* / gamma-aminobutyric acid type A receptor rho1 subunit*ENSMUSG0000002828037
Gabrp / Q8QZW7 / Gamma-aminobutyric acid receptor subunit pi / O00591* / gamma-aminobutyric acid type A receptor pi subunit*ENSMUSG0000002015936
Gabrd / P22933 / Gamma-aminobutyric acid receptor subunit delta / O14764* / gamma-aminobutyric acid type A receptor delta subunit*ENSMUSG0000002905436
Glra3 / glycine receptor alpha 3 / O75311*ENSMUSG0000003825735
Glra4 / Q61603 / Glycine receptor subunit alpha-4 / Q5JXX5* / glycine receptor alpha 4*ENSMUSG0000001859535
Gabrr3 / gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene) / A8MPY1*ENSMUSG0000007499134
Glra2 / Q7TNC8 / Mus musculus glycine receptor, alpha 2 subunit (Glra2), transcript variant 3, mRNA. / P23416* / glycine receptor alpha 2*ENSMUSG0000001858934
Glra1 / Q64018 / Glycine receptor subunit alpha-1 / P23415* / glycine receptor alpha 1*ENSMUSG0000000026334
Gabrr2 / P56476 / Gamma-aminobutyric acid receptor subunit rho-2 / P28476* / gamma-aminobutyric acid type A receptor rho2 subunit*ENSMUSG0000002326734
Glrb / P48168 / Glycine receptor subunit beta / P48167* / glycine receptor beta*ENSMUSG0000002802031


Protein motifs (from Interpro)
Interpro ID Name
 IPR002289  Gamma-aminobutyric-acid A receptor, beta subunit
 IPR006028  Gamma-aminobutyric acid A receptor/Glycine receptor alpha
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0043523 regulation of neuron apoptotic process IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0048666 neuron development IMP
 biological_processGO:0051932 synaptic transmission, GABAergic IEA
 biological_processGO:0060119 inner ear receptor cell development IMP
 biological_processGO:0060384 innervation IMP
 biological_processGO:0071420 cellular response to histamine ISS
 biological_processGO:0090102 cochlea development IMP
 biological_processGO:1901215 negative regulation of neuron death IMP
 biological_processGO:1902476 chloride transmembrane transport ISS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:1902710 GABA receptor complex IEA
 cellular_componentGO:1902711 GABA-A receptor complex ISS
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004890 GABA-A receptor activity ISS
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005237 inhibitory extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005254 chloride channel activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016917 GABA receptor activity IEA


Pathways (from Reactome)
Pathway description
GABA A receptor activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Gabra1tm1Twr/Gabra1tm1Twr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004008 abnormal GABA receptor currents "change in the measured amplitude or duration of response to stimulation of GABA receptors" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gabra1tm1Twr/Gabra1tm1Twr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004287 abnormal spiral limbus morphology "any structural abnormality in the border of the spiral lamina, i.e. the thickened periosteum covering the upper plate of the bony spiral lamina of the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004490 type IV spiral ligament fibrocyte degeneration "degeneration or loss of type IV spiral ligament fibrocytes found in the triangular space inferior to the basilar crest" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004632 abnormal cochlear OHC efferent innervation "any changes in the morphology or number of efferent terminals, occurring as clusters, in the cochlear OHC region; normally, medial olivocochlear neurons, which are primarily found in rostral and ventral periolivary regions, project mainly to the contralateral cochlea, and terminate directly on OHCs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004736 abnormal distortion product otoacoustic emission "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004740 sensorineural hearing loss "a form of progressive hearing loss due to a lesion of the auditory division of cranial nerve VIII or the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009745 abnormal behavioral response to xenobiotic "any anomaly in the behavioral response induced by a foreign compound, such as consumption preference, induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Rjo
Genetic Background: Not Specified

 MP:0011966 abnormal auditory brainstem response waveform shape "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007653 Gabrb2 / P63137 / Gamma-aminobutyric acid receptor subunit beta-2 / P47870* / gamma-aminobutyric acid type A receptor beta2 subunit*  / complex
 ENSMUSG00000029212 Gabrb1 / P50571 / Gamma-aminobutyric acid receptor subunit beta-1 / P18505* / gamma-aminobutyric acid type A receptor beta1 subunit*  / complex
 ENSMUSG00000031344 Gabrq / Q9JLF1 / Gamma-aminobutyric acid receptor subunit theta / Q9UN88* / gamma-aminobutyric acid type A receptor theta subunit*  / complex
 ENSMUSG00000033676 Gabrb3 / P63080 / Gamma-aminobutyric acid receptor subunit beta-3 / P28472* / gamma-aminobutyric acid type A receptor beta3 subunit*  / complex
 ENSMUSG00000020436 Gabrg2 / P22723 / Gamma-aminobutyric acid receptor subunit gamma-2 / P18507* / gamma-aminobutyric acid type A receptor gamma2 subunit*  / complex
 ENSMUSG00000055026 Gabrg3 / P27681 / Gamma-aminobutyric acid receptor subunit gamma-3 / Q99928* / gamma-aminobutyric acid type A receptor gamma3 subunit*  / complex






 

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