ENSMUSG00000031343


Mus musculus

Features
Gene ID: ENSMUSG00000031343
  
Biological name :Gabra3
  
Synonyms : Gabra3 / Mus musculus gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3 (Gabra3), transcript variant 3, mRNA. / P26049
  
Possible biological names infered from orthology : gamma-aminobutyric acid type A receptor alpha3 subunit / P34903
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A7.3
Gene start: 72432681
Gene end: 72656848
  
Corresponding Affymetrix probe sets: 10604961 (MoGene1.0st)   1421263_at (Mouse Genome 430 2.0 Array)   1436957_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000062638
Ensembl peptide - ENSMUSP00000110201
NCBI entrez gene - 14396     See in Manteia.
MGI - MGI:95615
RefSeq - NM_001358103
RefSeq - NM_008067
RefSeq - XM_017318383
RefSeq - NM_001357814
RefSeq - NM_001357815
RefSeq - NM_001357816
RefSeq - XM_006527823
RefSeq - XM_011247522
RefSeq Peptide - NP_001344743
RefSeq Peptide - NP_001344744
RefSeq Peptide - NP_032093
RefSeq Peptide - NP_001344745
RefSeq Peptide - NP_001345032
swissprot - P26049
swissprot - B1AVY2
Ensembl - ENSMUSG00000031343
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gabra3ENSDARG00000090883Danio rerio
 GABRA3ENSGALG00000007269Gallus gallus
 GABRA3ENSG00000011677Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gabra1 / P62812 / Mus musculus gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 (Gabra1), transcript variant 2, mRNA. / P14867* / gamma-aminobutyric acid type A receptor alpha1 subunit*ENSMUSG0000001080366
Gabra2 / P26048 / Gamma-aminobutyric acid receptor subunit alpha-2 / P47869* / gamma-aminobutyric acid type A receptor alpha2 subunit*ENSMUSG0000000056066
Gabra5 / Q8BHJ7 / Gamma-aminobutyric acid receptor subunit alpha-5 / P31644* / gamma-aminobutyric acid type A receptor alpha5 subunit*ENSMUSG0000005507866
Gabra4 / Q9D6F4 / Gamma-aminobutyric acid receptor subunit alpha-4 / P48169* / gamma-aminobutyric acid type A receptor alpha4 subunit*ENSMUSG0000002921154
Gabra6 / P16305 / Gamma-aminobutyric acid receptor subunit alpha-6 / Q16445* / gamma-aminobutyric acid type A receptor alpha6 subunit*ENSMUSG0000002042852
Gabrg3 / P27681 / Gamma-aminobutyric acid receptor subunit gamma-3 / Q99928* / gamma-aminobutyric acid type A receptor gamma3 subunit*ENSMUSG0000005502639
Gabrg1 / Q9R0Y8 / Gamma-aminobutyric acid receptor subunit gamma-1 / Q8N1C3* / gamma-aminobutyric acid type A receptor gamma1 subunit*ENSMUSG0000000126039
Gabrg2 / P22723 / Gamma-aminobutyric acid receptor subunit gamma-2 / P18507* / gamma-aminobutyric acid type A receptor gamma2 subunit*ENSMUSG0000002043639
Gabre / P78334* / gamma-aminobutyric acid type A receptor epsilon subunit*ENSMUSG0000003134030


Protein motifs (from Interpro)
Interpro ID Name
 IPR001390  Gamma-aminobutyric-acid A receptor, alpha subunit
 IPR005433  Gamma-aminobutyric-acid A receptor, alpha 3 subunit
 IPR006028  Gamma-aminobutyric acid A receptor/Glycine receptor alpha
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0007214 gamma-aminobutyric acid signaling pathway IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:1902711 GABA-A receptor complex IBA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004890 GABA-A receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IEA


Pathways (from Reactome)
Pathway description
GABA A receptor activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

Allelic Composition: Gabra3tm1Dgen/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gabra3tm1Dgen/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004008 abnormal GABA receptor currents "change in the measured amplitude or duration of response to stimulation of GABA receptors" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gabra3tm2Uru/Y
Genetic Background: 129X1(Cg)-Gabra3tm2Uru

Allelic Composition: Gabra3tm1Dgen/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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