ENSMUSG00000021990


Mus musculus

Features
Gene ID: ENSMUSG00000021990
  
Biological name :Spata13
  
Synonyms : Spata13 / spermatogenesis associated 13
  
Possible biological names infered from orthology : AL359736.1 / Q96N96
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: D1
Gene start: 60634001
Gene end: 60764556
  
Corresponding Affymetrix probe sets: 10415725 (MoGene1.0st)   1437865_at (Mouse Genome 430 2.0 Array)   1454656_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123928
Ensembl peptide - ENSMUSP00000123888
Ensembl peptide - ENSMUSP00000124586
Ensembl peptide - ENSMUSP00000125702
Ensembl peptide - ENSMUSP00000125163
Ensembl peptide - ENSMUSP00000022566
Ensembl peptide - ENSMUSP00000123744
NCBI entrez gene - 219140     See in Manteia.
MGI - MGI:104838
RefSeq - XM_017315975
RefSeq - NM_001033272
RefSeq - NM_001310594
RefSeq - XM_006518870
RefSeq - XM_011245025
RefSeq - XM_011245026
RefSeq - XM_011245027
RefSeq - XM_017315973
RefSeq Peptide - NP_001297523
RefSeq Peptide - NP_001028444
swissprot - E0CZ51
swissprot - F6SRZ4
swissprot - F6V9S1
swissprot - E0CYU0
swissprot - E0CXN6
swissprot - E9Q3I3
Ensembl - ENSMUSG00000021990
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spata13ENSDARG00000062837Danio rerio
 ENSGALG00000034674Gallus gallus
 AL359736.1ENSG00000273167Homo sapiens
 Q96N96ENSG00000182957Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3UTH8 / Arhgef9 / Rho guanine nucleotide exchange factor 9 / O43307* / Cdc42 guanine nucleotide exchange factor 9*ENSMUSG0000002565626
Q7TNR9 / Arhgef4 / Rho guanine nucleotide exchange factor 4 / Q9NR80*ENSMUSG0000003750925
Tiam1 / T cell lymphoma invasion and metastasis 1 / Q13009*ENSMUSG0000000248916
Tiam2 / Q6ZPF3 / T-lymphoma invasion and metastasis-inducing protein 2 / Q8IVF5* / T cell lymphoma invasion and metastasis 2*ENSMUSG0000002380016
Prex1 / Q69ZK0 / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein / Q8TCU6* / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1*ENSMUSG0000003962113
Prex2 / Q3LAC4 / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein / Q70Z35* / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2*ENSMUSG0000004896012
Arhgef6 / Rac/Cdc42 guanine nucleotide exchange factor 6 / Q15052*ENSMUSG0000003113310
Q9ES28 / Arhgef7 / Rho guanine nucleotide exchange factor 7 / Q14155*ENSMUSG0000003151110
Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*ENSMUSG0000003411610
Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*ENSMUSG0000000962110
Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*ENSMUSG000000337219


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: ApcMin/Apc+,Spata13tm1Taki/Spata13tm1Taki
Genetic Background: B6J.Cg-Spata13tm1Taki ApcMin

Allelic Composition: ApcMin/Apc+,Spata13tm1Taki/Spata13+
Genetic Background: B6J.Cg-Spata13tm1Taki ApcMin

Allelic Composition: ApcMin/Apc+,Arhgef4tm1Taki/Arhgef4tm1Taki,Spata13tm1Taki/Spata13tm1Taki
Genetic Background: B6J.Cg-Arhgef4tm1Taki Spata13tm1Taki ApcMin

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Arhgef4tm1Taki/Arhgef4tm1Taki,Spata13tm1Taki/Spata13tm1Taki
Genetic Background: B6J.Cg-Arhgef4tm1Taki Spata13tm1Taki ApcMin

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Arhgef4tm1Taki/Arhgef4tm1Taki,Spata13tm1Taki/Spata13tm1Taki
Genetic Background: B6J.Cg-Arhgef4tm1Taki Spata13tm1Taki ApcMin

 MP:0010639 altered tumor pathology "any changes associated with the chemistry, immunohistology, cellular alterations or environmental interactions of tumors compared to the expected state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Arhgef4tm1Taki/Arhgef4tm1Taki,Spata13tm1Taki/Spata13tm1Taki
Genetic Background: B6J.Cg-Arhgef4tm1Taki Spata13tm1Taki ApcMin

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Spata13tm1Taki/Spata13tm1Taki
Genetic Background: B6J.Cg-Spata13tm1Taki ApcMin

 MP:0012434 decreased intestinal adenoma incidence "less than the expected number of a benign epithelial neoplasm with a glandular organization arising in the small and/or large intestine, occurring in a specific population in a given time period" [MGI:csmith]
Show

Allelic Composition: ApcMin/Apc+,Spata13tm1Taki/Spata13tm1Taki
Genetic Background: B6J.Cg-Spata13tm1Taki ApcMin

Allelic Composition: ApcMin/Apc+,Spata13tm1Taki/Spata13+
Genetic Background: B6J.Cg-Spata13tm1Taki ApcMin

Allelic Composition: ApcMin/Apc+,Arhgef4tm1Taki/Arhgef4tm1Taki,Spata13tm1Taki/Spata13tm1Taki
Genetic Background: B6J.Cg-Arhgef4tm1Taki Spata13tm1Taki ApcMin

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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