ENSDARG00000012914


Danio rerio

Features
Gene ID: ENSDARG00000012914
  
Biological name :arhgef4
  
Synonyms : arhgef4 / Rho guanine nucleotide exchange factor (GEF) 4
  
Possible biological names infered from orthology : Q7TNR9 / Q9NR80 / Rho guanine nucleotide exchange factor 4
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 16198735
Gene end: 16359042
  
Corresponding Affymetrix probe sets: Dr.7600.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000121185
Ensembl peptide - ENSDARP00000142763
Ensembl peptide - ENSDARP00000140976
Ensembl peptide - ENSDARP00000126484
Ensembl peptide - ENSDARP00000057215
NCBI entrez gene - 559017     See in Manteia.
RefSeq - XM_009298440
swissprot - A0A1D5NSE9
swissprot - A0A0R4IZG0
swissprot - E7FAH9
swissprot - K7DYF5
swissprot - F6P744
ZFIN ID - ZDB-GENE-070912-575
Ensembl - ENSDARG00000012914
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ARHGEF4ENSGALG00000002193Gallus gallus
 Q9NR80ENSG00000136002Homo sapiens
 Q7TNR9ENSMUSG00000037509Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
spata13 / spermatogenesis associated 13 / Q96N96* / AL359736.1*ENSDARG0000006283712
arhgef9b / Cdc42 guanine nucleotide exchange factor (GEF) 9b / O43307* / Q3UTH8* / ARHGEF9* / Rho guanine nucleotide exchange factor 9 * / Cdc42 guanine nucleotide exchange factor 9*ENSDARG0000007862410
arhgef9a / Cdc42 guanine nucleotide exchange factor (GEF) 9a / O43307* / Q3UTH8* / ARHGEF9* / Rho guanine nucleotide exchange factor 9 * / Cdc42 guanine nucleotide exchange factor 9*ENSDARG0000006174610
tiam2a / T cell lymphoma invasion and metastasis 2a / TIAM2* / Q8IVF5* / Q6ZPF3* / T cell lymphoma invasion and metastasis 2* / T-lymphoma invasion and metastasis-inducing protein 2 *ENSDARG000000877806
tiam1a / T cell lymphoma invasion and metastasis 1a / TIAM1* / Q13009* / T cell lymphoma invasion and metastasis 1*ENSDARG000000784306
prex1 / phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 / Q69ZK0* / Q8TCU6* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein *ENSDARG000000757935
prex2 / phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 / Q3LAC4* / Q70Z35* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein *ENSDARG000000716925
tiam1b / T cell lymphoma invasion and metastasis 1b / TIAM1* / Q13009* / T cell lymphoma invasion and metastasis 1*ENSDARG000000259205
arhgef7b / Rho guanine nucleotide exchange factor (GEF) 7b / Q14155* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*ENSDARG000000738484
vav3b / vav 3 guanine nucleotide exchange factor b / VAV3* / Q9UKW4* / Q9R0C8* / vav 3 oncogene* / vav guanine nucleotide exchange factor 3*ENSDARG000000759624
arhgef7a / Rho guanine nucleotide exchange factor (GEF) 7a / Q14155* / Q9ES28* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*ENSDARG000000062994
arhgef6 / Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 / Q15052* / Rac/Cdc42 guanine nucleotide exchange factor 6*ENSDARG000000066834
vav2 / vav 2 guanine nucleotide exchange factor / Q60992* / P52735* / vav 2 oncogene* / vav guanine nucleotide exchange factor 2*ENSDARG000000447183
tiam2b / T cell lymphoma invasion and metastasis 2b / TIAM2* / Q8IVF5* / T cell lymphoma invasion and metastasis 2*ENSDARG000000982332
si:ch73-383g2.1ENSDARG000000571072
si:dkey-21o19.2ENSDARG000000889001
CABZ01114581.1ENSDARG000001125260
vav3a / vav 3 guanine nucleotide exchange factor aENSDARG000000866230


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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