ENSG00000136002


Homo sapiens

Features
Gene ID: ENSG00000136002
  
Biological name :ARHGEF4
  
Synonyms : ARHGEF4 / Q9NR80 / Rho guanine nucleotide exchange factor 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q21.1
Gene start: 130836916
Gene end: 131047263
  
Corresponding Affymetrix probe sets: 205109_s_at (Human Genome U133 Plus 2.0 Array)   211891_s_at (Human Genome U133 Plus 2.0 Array)   216912_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000386794
Ensembl peptide - ENSP00000490717
Ensembl peptide - ENSP00000483548
Ensembl peptide - ENSP00000432301
Ensembl peptide - ENSP00000432267
Ensembl peptide - ENSP00000398455
Ensembl peptide - ENSP00000389661
Ensembl peptide - ENSP00000387285
Ensembl peptide - ENSP00000316845
Ensembl peptide - ENSP00000348017
Ensembl peptide - ENSP00000376680
NCBI entrez gene - 50649     See in Manteia.
OMIM - 605216
RefSeq - XM_011511277
RefSeq - NM_015320
RefSeq - NM_032995
RefSeq - XM_005263681
RefSeq - XM_005263687
RefSeq - XM_005263688
RefSeq - XM_005263689
RefSeq - XM_011511274
RefSeq - XM_011511276
RefSeq Peptide - NP_056135
RefSeq Peptide - NP_127462
swissprot - A0A1B0GW00
swissprot - A0A0C4DFY6
swissprot - A0A087X0P1
swissprot - E7EV07
swissprot - H0Y451
swissprot - H0YCT6
swissprot - E9PEM0
swissprot - Q9NR80
swissprot - A4QPB6
Ensembl - ENSG00000136002
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef4ENSDARG00000012914Danio rerio
 ARHGEF4ENSGALG00000002193Gallus gallus
 Q7TNR9ENSMUSG00000037509Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q96N96 / SPATA13 / spermatogenesis associated 13ENSG0000018295754
AL359736.1ENSG0000027316748
O43307 / ARHGEF9 / Cdc42 guanine nucleotide exchange factor 9ENSG0000013108944
PREX1 / Q8TCU6 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1ENSG0000012412625
PREX2 / Q70Z35 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2ENSG0000004688922
TIAM2 / Q8IVF5 / T cell lymphoma invasion and metastasis 2ENSG0000014642620
TIAM1 / Q13009 / T cell lymphoma invasion and metastasis 1ENSG0000015629920
Q14155 / ARHGEF7 / Rho guanine nucleotide exchange factor 7ENSG0000010260617
VAV1 / P15498 / vav guanine nucleotide exchange factor 1ENSG0000014196817
VAV2 / P52735 / vav guanine nucleotide exchange factor 2ENSG0000016029317
Q15052 / ARHGEF6 / Rac/Cdc42 guanine nucleotide exchange factor 6ENSG0000012967516
VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3ENSG0000013421515


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0030032 lamellipodium assembly IMP
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0046847 filopodium assembly IMP
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IMP


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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