ENSG00000046889


Homo sapiens

Features
Gene ID: ENSG00000046889
  
Biological name :PREX2
  
Synonyms : phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 / PREX2 / Q70Z35
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q13.2
Gene start: 67952118
Gene end: 68237030
  
Corresponding Affymetrix probe sets: 1569934_at (Human Genome U133 Plus 2.0 Array)   220732_at (Human Genome U133 Plus 2.0 Array)   228692_at (Human Genome U133 Plus 2.0 Array)   233408_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000288368
NCBI entrez gene - 80243     See in Manteia.
OMIM - 612139
RefSeq - NM_024870
RefSeq - XM_011517612
RefSeq Peptide - NP_079146
swissprot - Q70Z35
Ensembl - ENSG00000046889
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prex2ENSDARG00000071692Danio rerio
 PREX2ENSGALG00000042354Gallus gallus
 Prex2ENSMUSG00000048960Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PREX1 / Q8TCU6 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1ENSG0000012412658
Q9NR80 / ARHGEF4 / Rho guanine nucleotide exchange factor 4ENSG000001360029
VAV1 / P15498 / vav guanine nucleotide exchange factor 1ENSG000001419689
VAV2 / P52735 / vav guanine nucleotide exchange factor 2ENSG000001602939
O43307 / ARHGEF9 / Cdc42 guanine nucleotide exchange factor 9ENSG000001310899
Q96N96 / SPATA13 / spermatogenesis associated 13ENSG000001829579
VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3ENSG000001342158
AL359736.1ENSG000002731678
TIAM2 / Q8IVF5 / T cell lymphoma invasion and metastasis 2ENSG000001464268
Q14155 / ARHGEF7 / Rho guanine nucleotide exchange factor 7ENSG000001026067
TIAM1 / Q13009 / T cell lymphoma invasion and metastasis 1ENSG000001562997
Q15052 / ARHGEF6 / Rac/Cdc42 guanine nucleotide exchange factor 6ENSG000001296757


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000591  DEP domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001478  PDZ domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036034  PDZ superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily
 IPR037367  PREX2, DEP domain 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0032007 negative regulation of TOR signaling IBA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0048813 dendrite morphogenesis IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IDA


Pathways (from Reactome)
Pathway description
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000171862 PTEN / P60484 / phosphatase and tensin homolog  / complex / reaction






 

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