ENSG00000146426


Homo sapiens

Features
Gene ID: ENSG00000146426
  
Biological name :TIAM2
  
Synonyms : Q8IVF5 / T cell lymphoma invasion and metastasis 2 / TIAM2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: q25.2
Gene start: 154832697
Gene end: 155257723
  
Corresponding Affymetrix probe sets: 219950_s_at (Human Genome U133 Plus 2.0 Array)   222942_s_at (Human Genome U133 Plus 2.0 Array)   227866_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000442989
Ensembl peptide - ENSP00000444897
Ensembl peptide - ENSP00000444040
Ensembl peptide - ENSP00000443546
Ensembl peptide - ENSP00000275246
Ensembl peptide - ENSP00000353528
Ensembl peptide - ENSP00000407183
Ensembl peptide - ENSP00000431269
Ensembl peptide - ENSP00000433348
Ensembl peptide - ENSP00000434901
Ensembl peptide - ENSP00000435335
Ensembl peptide - ENSP00000437188
Ensembl peptide - ENSP00000437435
NCBI entrez gene - 26230     See in Manteia.
OMIM - 604709
RefSeq - NM_001010927
RefSeq - NM_012454
RefSeq Peptide - NP_001010927
RefSeq Peptide - NP_036586
swissprot - H0YGV1
swissprot - H7C5V6
swissprot - E9PMZ8
swissprot - Q8IVF5
swissprot - E9PKT1
swissprot - F5H1M3
swissprot - F5H6R0
swissprot - F5H6W6
Ensembl - ENSG00000146426
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tiam2aENSDARG00000087780Danio rerio
 tiam2bENSDARG00000098233Danio rerio
 TIAM2ENSGALG00000036005Gallus gallus
 Tiam2ENSMUSG00000023800Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TIAM1 / Q13009 / T cell lymphoma invasion and metastasis 1ENSG0000015629938
Q96N96 / SPATA13 / spermatogenesis associated 13ENSG0000018295712
AL359736.1ENSG0000027316711
PREX1 / Q8TCU6 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1ENSG000001241268
Q9NR80 / ARHGEF4 / Rho guanine nucleotide exchange factor 4ENSG000001360028
VAV1 / P15498 / vav guanine nucleotide exchange factor 1ENSG000001419688
PREX2 / Q70Z35 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2ENSG000000468898
Q14155 / ARHGEF7 / Rho guanine nucleotide exchange factor 7ENSG000001026068
Q15052 / ARHGEF6 / Rac/Cdc42 guanine nucleotide exchange factor 6ENSG000001296758
VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3ENSG000001342158
O43307 / ARHGEF9 / Cdc42 guanine nucleotide exchange factor 9ENSG000001310897
VAV2 / P52735 / vav guanine nucleotide exchange factor 2ENSG000001602937


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001478  PDZ domain
 IPR001849  Pleckstrin homology domain
 IPR003116  Raf-like Ras-binding
 IPR011993  PH-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
PPARA activates gene expression
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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