ENSGALG00000036005


Gallus gallus

Features
Gene ID: ENSGALG00000036005
  
Biological name :TIAM2
  
Synonyms : T cell lymphoma invasion and metastasis 2 / TIAM2
  
Possible biological names infered from orthology : Q6ZPF3 / Q8IVF5 / T-lymphoma invasion and metastasis-inducing protein 2
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 50653163
Gene end: 50738444
  
Corresponding Affymetrix probe sets: Gga.14261.1.A1_at (Chicken Array)   Gga.14261.1.S1_at (Chicken Array)   Gga.18505.1.S1_s_at (Chicken Array)   GgaAffx.20761.1.S1_at (Chicken Array)   GgaAffx.24239.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000054100
NCBI entrez gene - 421648     See in Manteia.
RefSeq - NM_001267535
RefSeq - XM_015284073
RefSeq - XM_015284074
RefSeq Peptide - NP_001254464
swissprot - A0A1D5PML9
Ensembl - ENSGALG00000036005
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tiam2aENSDARG00000087780Danio rerio
 tiam2bENSDARG00000098233Danio rerio
 TIAM2ENSG00000146426Homo sapiens
 Tiam2ENSMUSG00000023800Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TIAM1 / T cell lymphoma invasion and metastasis 1 / Q13009*ENSGALG0000001584237
Q5ZLR6 / ARHGEF6 / Rho guanine nucleotide exchange factor 6 / Q15052* / Rac/Cdc42 guanine nucleotide exchange factor 6*ENSGALG000000064398
VAV3 / vav guanine nucleotide exchange factor 3 / Q9R0C8* / Q9UKW4* / vav 3 oncogene*ENSGALG000000393278
ARHGEF4 / Rho guanine nucleotide exchange factor 4 / Q7TNR9* / Q9NR80*ENSGALG000000021937
PREX2 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 / Q3LAC4* / Q70Z35* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein *ENSGALG000000423547
VAV2 / guanine nucleotide exchange factor VAV2 / Q60992* / P52735* / vav 2 oncogene* / vav guanine nucleotide exchange factor 2*ENSGALG000000026997
PREX1 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 / Q69ZK0* / Q8TCU6* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein *ENSGALG000000046217
Q96N96* / SPATA13* / AL359736.1* / spermatogenesis associated 13*ENSGALG000000346746
ARHGEF7 / Rho guanine nucleotide exchange factor 7 / Q14155* / Q9ES28*ENSGALG000000310096
ARHGEF9 / Cdc42 guanine nucleotide exchange factor 9 / O43307* / Q3UTH8* / Rho guanine nucleotide exchange factor 9 *ENSGALG000000076086
ENSGALG000000018943
ENSGALG000000362530


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001478  PDZ domain
 IPR001849  Pleckstrin homology domain
 IPR003116  Raf-like Ras-binding
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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