ENSGALG00000042354


Gallus gallus

Features
Gene ID: ENSGALG00000042354
  
Biological name :PREX2
  
Synonyms : phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 / PREX2
  
Possible biological names infered from orthology : Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein / Q3LAC4 / Q70Z35
  
Species: Gallus gallus
  
Chr. number: 2
Strand: 1
Band:
Gene start: 116026798
Gene end: 116131725
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSGALP00000047884
NCBI entrez gene - 420172     See in Manteia.
RefSeq - XM_418285
swissprot - A0A1D5P5B7
Ensembl - ENSGALG00000042354
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prex2ENSDARG00000071692Danio rerio
 PREX2ENSG00000046889Homo sapiens
 Prex2ENSMUSG00000048960Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PREX1 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 / Q69ZK0* / Q8TCU6* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein *ENSGALG0000000462155
ARHGEF4 / Rho guanine nucleotide exchange factor 4 / Q7TNR9* / Q9NR80*ENSGALG0000000219313
Q96N96* / SPATA13* / AL359736.1* / spermatogenesis associated 13*ENSGALG0000003467412
ARHGEF9 / Cdc42 guanine nucleotide exchange factor 9 / O43307* / Q3UTH8* / Rho guanine nucleotide exchange factor 9 *ENSGALG0000000760812
VAV2 / guanine nucleotide exchange factor VAV2 / Q60992* / P52735* / vav 2 oncogene* / vav guanine nucleotide exchange factor 2*ENSGALG0000000269911
TIAM2 / T cell lymphoma invasion and metastasis 2 / Q6ZPF3* / Q8IVF5* / T-lymphoma invasion and metastasis-inducing protein 2 *ENSGALG0000003600510
VAV3 / vav guanine nucleotide exchange factor 3 / Q9R0C8* / Q9UKW4* / vav 3 oncogene*ENSGALG0000003932710
Q5ZLR6 / ARHGEF6 / Rho guanine nucleotide exchange factor 6 / Q15052* / Rac/Cdc42 guanine nucleotide exchange factor 6*ENSGALG0000000643910
ARHGEF7 / Rho guanine nucleotide exchange factor 7 / Q14155* / Q9ES28*ENSGALG000000310099
TIAM1 / T cell lymphoma invasion and metastasis 1 / Q13009*ENSGALG000000158429
ENSGALG000000018943
ENSGALG000000362531


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000591  DEP domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001478  PDZ domain
 IPR001849  Pleckstrin homology domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0048813 dendrite morphogenesis IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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