| MP:0000060 | delayed bone ossification | "late onset of the formation of bone" [J:40203] |
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Allelic Composition: Lrp5tm1Kry/Lrp5tm1Kry
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
Allelic Composition: Lrp5tm1Kry/Lrp5+
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
|
| MP:0000062 | increased bone density | "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295] |
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Allelic Composition: Pax5m1Btlr/Pax5m1Btlr
Genetic Background: C57BL/6J-Pax5m1Btlr
|
| MP:0000063 | reduced bone density | "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
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Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Lrp5tm1Lex/Lrp5tm1Lex
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N
Allelic Composition: Lrp5tm1Lex/Lrp5+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N
Allelic Composition: Lrp5tm1Lex/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N
Allelic Composition: Lrp5tm1Lex/Lrp5tm1Lex,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N
Allelic Composition: Lrp5tm1Lex/Lrp5tm1Lex,Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N
Allelic Composition: Lrp5Gt(OST164883)Lex/Lrp5Gt(OST164883)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
|
| MP:0000066 | osteoporosis | "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
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Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas
|
| MP:0000130 | abnormal cancellous bone morphology | "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Lrp5tm1Lex/Lrp5+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N
Allelic Composition: Lrp5tm1Kry/Lrp5tm1Kry
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
Allelic Composition: Lrp5Gt(OST164883)Lex/Lrp5Gt(OST164883)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
Allelic Composition: Lrp5tm1.1Vari/Lrp5tm1.1Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0000163 | abnormal cartilage morphology | "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Lrp6tm1.1Vari/Lrp6tm1.2Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0000255 | vasculature congestion | "obstruction of the normal flux of blood within the blood vessel network" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: HrN/Hrhr
Genetic Background: involves: ORNL:STOCK Aw/a Oca2p
|
| MP:0000260 | abnormal angiogenesis | "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Fzd4tm1Nat/Fzd4+,Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129 * C57BL/6 * CBA
|
| MP:0000438 | abnormal skull morphology | "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lrp5tm1Lex/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N
Allelic Composition: Lrp5tm1.1Vari/Lrp5tm1.1Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0000550 | abnormal forelimb morphology | "malformation of the entire anterior extremities" [MGI:tc] |
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Allelic Composition: Lrp5tm1Lex/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N
Allelic Composition: Lrp5tm1Lex/Lrp5tm1Lex,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N
|
| MP:0000554 | abnormal carpal bone morphology | "malformation of the nine nodular bones of the joint between the forelimb bones and the front paws consisting of the scapholunar, triangular, greater multiangular, lesser multiangular, capitate, hamate, centrale and the sesamoids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935] |
Show
Allelic Composition: Lrp5tm1Lex/Lrp5tm1Lex,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N
|
| MP:0000555 | absent carpal bone | "missing the wrist bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54637] |
Show
Allelic Composition: Lrp5tm1Jfh/Lrp5tm1Jfh,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
|
| MP:0000556 | abnormal hindlimb morphology | "malformation of the entire posterior extremities" [MGI:tc] |
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Allelic Composition: Lrp5tm1Lex/Lrp5tm1Lex,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N
|
| MP:0000559 | abnormal femur morphology | "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Lrp5tm1Jsak/Lrp5tm1Jsak
Genetic Background: involves: C57BL/6 * CBA
|
| MP:0000565 | oligodactyly | "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Lrp5tm1Jfh/Lrp5tm1Jfh,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
Allelic Composition: Lrp5tm1Jfh/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
Allelic Composition: Lrp5tm1Lex/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N
Allelic Composition: Lrp5tm1Lex/Lrp5tm1Lex,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N
|
| MP:0000566 | synostosis | "osseous union of two bones that are not normally connected" [J:13049] |
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Allelic Composition: Lrp5tm1Lex/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N
Allelic Composition: Lrp5tm1Lex/Lrp5tm1Lex,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N
|
| MP:0000609 | abnormal liver physiology | "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Lrp5tm1Jsak/Lrp5tm1Jsak
Genetic Background: involves: C57BL/6 * CBA
|
| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
Show
Allelic Composition: Lrp5Gt(OST164883)Lex/Lrp5Gt(OST164883)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
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| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Igk-V21-Bax)1967Bvn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N
Allelic Composition: Lrp5tm1.1Vari/Lrp5tm1.1Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0001286 | abnormal eye development | "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840] |
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Allelic Composition: Lrp5tm1Kry/Lrp5tm1Kry
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
|
| MP:0001289 | persistence of hyaloid capillary system | "failure of the degeneration of the transient vascular system of the eye during development" [J:49840] |
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Allelic Composition: Ncoa1tm1Hkaw/Ncoa1tm1Hkaw
Genetic Background: involves: C57BL/6J
Allelic Composition: Lrp5tm1Kry/Lrp5tm1Kry
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
Allelic Composition: Lrp5tm1Kry/Lrp5tm1Kry
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Lrp5tm1Dgen/Lrp5tm1Dgen
Genetic Background: B6.129P2-Lrp5tm1Dgen/J
Allelic Composition: Lrp5tvrm111B/Lrp5tvrm111B
Genetic Background: C57BL/6J-Lrp5tvrm111b/Pjn
|
| MP:0001325 | abnormal retina morphology | "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Lrp5tm1Dgen/Lrp5tm1Dgen
Genetic Background: B6.129P2-Lrp5tm1Dgen/J
|
| MP:0001326 | retinal degeneration | "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator] |
Show
Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
|
| MP:0001402 | hypoactivity | "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289] |
Show
Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
|
| MP:0001674 | abnormal triploblastic development | "abnormal development of the three primary germ layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Igk-V21-Bax)1967Bvn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N
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| MP:0001680 | abnormal mesoderm development | "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Igk-V21-Bax)1967Bvn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N
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| MP:0002084 | abnormal developmental patterning | "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Igk-V21-Bax)1967Bvn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N
Allelic Composition: Lrp5tm1Jfh/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
|
| MP:0002086 | abnormal extraembryonic tissue morphology | "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Lrp5tm1Jfh/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
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| MP:0002090 | abnormal vision | "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Fzd9tm1Uta/Fzd9+
Genetic Background: involves: 129X1/SvJ
|
| MP:0002109 | abnormal limb morphology | "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Lrp5tm1Lex/Lrp5+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N
Allelic Composition: Lrp5tm1Lex/Lrp5tm1Lex,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N
Allelic Composition: Lrp5tm1Jsak/Lrp5tm1Jsak
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Lrp5tm1.1Vari/Lrp5tm1.1Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Krt71Ca/Krt71Ca-2H
Genetic Background: involves: 101/H
|
| MP:0002183 | gliosis | "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0002230 | abnormal primitive streak formation | "anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Lrp5tm1Jfh/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
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| MP:0002727 | decreased circulating insulin level | "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Lrp5tm1Jsak/Lrp5tm1Jsak
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Lrp5tm1Jsak/Lrp5+
Genetic Background: involves: C57BL/6 * CBA
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| MP:0002792 | abnormal retinal vascularization | "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Lrp5tm1Kry/Lrp5tm1Kry
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Lrp5r18/Lrp5r18
Genetic Background: C57BL/6J-Lrp5r18
Allelic Composition: Lrp5Gt(OST164883)Lex/Lrp5Gt(OST164883)Lex
Genetic Background: involves: 129S5/SvEvBrd
Allelic Composition: Lrp5Gt(OST164883)Lex/Lrp5+,Tspan12tm1Wye/Tspan12+
Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N)
Allelic Composition: Lrp5tm1Dgen/Lrp5tm1Dgen
Genetic Background: B6.129P2-Lrp5tm1Dgen/J
Allelic Composition: Lrp5tvrm111B/Lrp5tvrm111B
Genetic Background: C57BL/6J-Lrp5tvrm111b/Pjn
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| MP:0002797 | thigmotaxis | "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814] |
Show
Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0002896 | abnormal bone mineralization | "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Lrp5tm1Kry/Lrp5tm1Kry
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0002932 | abnormal joint | "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0003049 | abnormal lumbar vertebrae morphology | "malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Lrp5Gt(OST164883)Lex/Lrp5Gt(OST164883)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
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| MP:0003059 | decreased insulin secretion | "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission] |
Show
Allelic Composition: Lrp5tm1Jsak/Lrp5tm1Jsak
Genetic Background: involves: C57BL/6 * CBA
|
| MP:0003070 | increased vascular permeability | "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Lrp5Gt(OST164883)Lex/Lrp5Gt(OST164883)Lex
Genetic Background: involves: 129S5/SvEvBrd
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| MP:0003074 | absent metacarpal bones | "missing the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phlanges" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935] |
Show
Allelic Composition: Lrp5tm1Jfh/Lrp5tm1Jfh,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
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| MP:0003087 | absent allantois | "missing fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Igk-V21-Bax)1967Bvn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N
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| MP:0003409 | decreased width of hypertrophic chondrocyte zone | "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0003727 | abnormal retinal layer morphology | "malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0003731 | abnormal outer nuclear layer morphology | "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0003732 | abnormal outer plexiform layer morphology | "malformation/anomalous structure of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0003795 | abnormal bone structure | |
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Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Lrp5Gt(OST164883)Lex/Lrp5Gt(OST164883)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
Allelic Composition: Lrp5tm1.1Vari/Lrp5tm1.1Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0003800 | monodactyly | "having only one toe or digit on each extremity" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Lrp5tm1Lex/Lrp5tm1Lex,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N
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| MP:0003869 | ectopic cartilage | "positional abnormality of cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Lrp5tm1.1Vari/Lrp5tm1.1Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0003982 | increased cholesterol level | "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Lrp5tm1Jsak/Lrp5tm1Jsak
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Lrp5tm1Jsak/Lrp5+
Genetic Background: involves: C57BL/6 * CBA
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| MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Lrp5tm1Kry/Lrp5tm1Kry,Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129 * C57BL/6 * CBA
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| MP:0004016 | decreased bone mass | "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Lrp5tm1Lex/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N
Allelic Composition: Lrp5tm1Lex/Lrp5tm1Lex,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N
Allelic Composition: Lrp5tm1Kry/Lrp5tm1Kry
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
Allelic Composition: Lrp5tm1Kry/Lrp5+
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
Allelic Composition: Lrp5Gt(OST164883)Lex/Lrp5Gt(OST164883)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
Allelic Composition: Lrp5tm1Kry/Lrp5tm1Kry
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Lrp5tm2Kry/Lrp5tm2Kry,Tg(Vil-cre)20Syr/0
Genetic Background: involves: C57BL/6 * DBA/2
Allelic Composition: Lrp5tm2Kry/Lrp5+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: C57BL/6 * DBA/2
Allelic Composition: Creb1tm3Gsc/Creb1+,Lrp5tm1Kry/Lrp5+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB
Allelic Composition: Lrp5tm3.2Mawa/Lrp5tm3.2Mawa
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N * SJL
Allelic Composition: Lrp5tm3.1Mawa/Lrp5tm3.1Mawa,Tg(Dmp1-cre)1Jqfe/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari
Genetic Background: involves: 129S1/Sv
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| MP:0004022 | abnormal cone electrophysiology | "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Lrp5tvrm111B/Lrp5tvrm111B
Genetic Background: C57BL/6J-Lrp5tvrm111b/Pjn
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| MP:0004148 | increased cortical bone thickness | "thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Hivep3tm1Glm/Hivep3tm1Glm,Lrp5tm3.2Mawa/Lrp5tm3.2Mawa
Genetic Background: involves: 129S1/Sv * C57BL/6
|
| MP:0004149 | increased bone strength | "increased ability of bone to endure the application of force without yielding or breaking" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Lrp5tm1Grw/Lrp5tm1Grw,Sosttm1Paz/Sosttm1Paz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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| MP:0004200 | reduced fetal size | "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lrp5tm1Jfh/Lrp5tm1Jfh,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
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| MP:0004214 | abnormal long bone diaphysis morphology | "any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lrp5Gt(OST164883)Lex/Lrp5Gt(OST164883)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
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| MP:0004231 | abnormal calcium ion homeostasis | "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lrp5tm1Jsak/Lrp5tm1Jsak
Genetic Background: involves: C57BL/6 * CBA
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| MP:0004320 | split sternum | "the appearance of an abnormal division in the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lrp5tm1.1Vari/Lrp5tm1.1Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0004985 | decreased osteoclast cell number | "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas
|
| MP:0004989 | decreased osteoblast cell number | "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Lrp5tm1Kry/Lrp5tm1Kry
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
Allelic Composition: Lrp5tm2Kry/Lrp5tm2Kry,Tg(Vil-cre)20Syr/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0004991 | decreased bone strength | "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas
|
| MP:0004993 | decreased bone resorption | "reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lrp5Gt(OST164883)Lex/Lrp5Gt(OST164883)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
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| MP:0005006 | abnormal osteoblast function | "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Lrp5tm1Kry/Lrp5tm1Kry
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
Allelic Composition: Lrp5tm1Kry/Lrp5+
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
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| MP:0005029 | abnormal amnion | "malformed innermost layer of the extraembryonic membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator] |
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Allelic Composition: Lrp5tm1Jfh/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
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| MP:0005030 | absent amnion | "missing innermost of the extraembryonic membranes" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761] |
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Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Igk-V21-Bax)1967Bvn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N
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| MP:0005104 | abnormal tarsus morphology | "malformation or absence of any of the eight bones of the instep of the paw: tibiale, talus, calcaneus, navicular, 3 cuneiform, and cuboid bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935] |
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Allelic Composition: Lrp5tm1Lex/Lrp5tm1Lex,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N
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| MP:0005145 | increased circulating VLDL cholesterol level | "greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Lrp5tm1Jsak/Lrp5tm1Jsak
Genetic Background: involves: C57BL/6 * CBA
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| MP:0005201 | abnormal retinal pigment epithelium morphology | "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
|
| MP:0005293 | impaired glucose tolerance | "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Lrp5tm1Jsak/Lrp5tm1Jsak
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Lrp5tm1Jsak/Lrp5+
Genetic Background: involves: C57BL/6 * CBA
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| MP:0005306 | abnormal phalanx morphology | "aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Igk-V21-Bax)1967Bvn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N
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| MP:0005322 | abnormal serotonin level | "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Lrp5tm1Kry/Lrp5tm1Kry
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Lrp5tm1Kry/Lrp5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Lrp5tm2Kry/Lrp5tm2Kry,Tg(Vil-cre)20Syr/0
Genetic Background: involves: C57BL/6 * DBA/2
Allelic Composition: Lrp5tm3(Lrp5*)Kry/Lrp5tm3(Lrp5*)Kry,Tg(Vil-cre)20Syr/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0005331 | insulin resistance | "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Lrp5tm1Jsak/Lrp5tm1Jsak
Genetic Background: involves: C57BL/6 * CBA
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| MP:0005430 | absent fibula | "missing the lateral and shorter of the two bones of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86196] |
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Allelic Composition: Lrp5tm1Jfh/Lrp5tm1Jfh,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
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| MP:0005508 | abnormal skeleton morphology | "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Lrp5tm1.1Vari/Lrp5tm1.1Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0005605 | increased bone mass | "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lrp5tm3(Lrp5*)Kry/Lrp5tm3(Lrp5*)Kry,Tg(Vil-cre)20Syr/0
Genetic Background: involves: C57BL/6 * DBA/2
Allelic Composition: Lrp5tm2Mawa/Lrp5+,Tg(Dmp1-cre)1Jqfe/0
Genetic Background: involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ * FVB/N
Allelic Composition: Lrp5tm1Mawa/Lrp5+,Tg(Dmp1-cre)1Jqfe/0
Genetic Background: involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ * FVB/N
Allelic Composition: Lrp5tm2.1Mawa/Lrp5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Allelic Composition: Lrp5tm1.1Mawa/Lrp5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Allelic Composition: Lrp5tm1Mawa/Lrp5+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Lrp5tm2Mawa/Lrp5+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Allelic Composition: Lrp5tm1.1Mawa/Lrp5tm1.1Mawa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Allelic Composition: Lrp5tm2.1Mawa/Lrp5tm2.1Mawa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Allelic Composition: Hivep3tm1Glm/Hivep3tm1Glm,Lrp5tm3.2Mawa/Lrp5tm3.2Mawa
Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Lrp5tm1Grw/Lrp5tm1Grw,Sosttm1Paz/Sosttm1Paz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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| MP:0006043 | decreased apoptosis | "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Lrp5tm1Kry/Lrp5tm1Kry
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
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| MP:0006069 | abnormal retinal neuronal layer morphology | "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3] |
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Allelic Composition: Lrp5tvrm111B/Lrp5tvrm111B
Genetic Background: C57BL/6J-Lrp5tvrm111b/Pjn
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| MP:0006303 | abnormal retinal nerve fiber layer morphology | "malformation of the layer of the retina formed by expansion of the fibers of the optic nerve" [ISBN:0-914294-08-3 "Gray s Anatomy", J:67382, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0006386 | absent somites | "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lrp5tm1Jfh/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
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| MP:0006395 | abnormal epiphyseal plate morphology | "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352] |
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Allelic Composition: Lrp5tm1.1Vari/Lrp5tm1.1Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0008067 | retinal ganglion cell degeneration | "degeneration or loss of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0008152 | decreased diameter of femur | "reduced width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lrp5tm1Jsak/Lrp5tm1Jsak
Genetic Background: involves: C57BL/6 * CBA
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| MP:0008156 | decreased diameter of tibia | "reduced width of the cross-sectional distance that extends from one lateral edge of the tibia, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lrp5tm1Jsak/Lrp5tm1Jsak
Genetic Background: involves: C57BL/6 * CBA
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| MP:0008271 | abnormal bone ossification | "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503] |
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Allelic Composition: Lrp5tm1Jfh/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
Allelic Composition: Lrp5tm1Kry/Lrp5tm1Kry
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
Allelic Composition: Lrp5tm1Kry/Lrp5+
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
Allelic Composition: Lrp5tm1.1Vari/Lrp5tm1.1Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0008274 | failure of bone ossification | "failure to initiate or a block in the process of the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503] |
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Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0008395 | abnormal osteoblast differentiation | "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0008450 | retinal photoreceptor degeneration | "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0008512 | disorganized retinal inner nuclear layer | "derangement of the normal pattern of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0008513 | thin retinal inner plexiform layer | "reduced thickness of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0008515 | thin retinal outer nuclear layer | "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0008516 | disorganized retinal outer nuclear layer | "derangement of the normal pattern of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0008519 | thin retinal outer plexiform layer | "reduced thickness of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0008520 | disorganized retinal outer plexiform layer | "a derangement of the normal pattern of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0009347 | increased cancellous bone thickness | "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hivep3tm1Glm/Hivep3tm1Glm,Lrp5tm3.2Mawa/Lrp5tm3.2Mawa
Genetic Background: involves: 129S1/Sv * C57BL/6
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| MP:0009869 | abnormal descending aorta morphology | "any strucutral anomaly of the part of the aorta extending from the arch of aorta to the point where it divides into the common iliac arteries" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lrp5tm1Kry/Lrp5tm1Kry,Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129 * C57BL/6 * CBA
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| MP:0010097 | abnormal retinal blood vessel morphology | "any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lrp5tm1Dgen/Lrp5tm1Dgen
Genetic Background: B6.129P2-Lrp5tm1Dgen/J
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| MP:0010123 | increased bone mineral content | "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lrp5tm1Grw/Lrp5tm1Grw,Sosttm1Paz/Sosttm1Paz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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| MP:0010124 | decreased bone mineral content | "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Lrp5tvrm111B/Lrp5tvrm111B
Genetic Background: C57BL/6J-Lrp5tvrm111b/Pjn
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| MP:0010867 | abnormal bone trabecula morphology | "any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lrp5tm3.2Mawa/Lrp5tm3.2Mawa
Genetic Background: involves: 129S1/Sv
Allelic Composition: Hivep3tm1Glm/Hivep3tm1Glm,Lrp5tm3.2Mawa/Lrp5tm3.2Mawa
Genetic Background: involves: 129S1/Sv * C57BL/6
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| MP:0010868 | increased bone trabecula number | "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hivep3tm1Glm/Hivep3tm1Glm,Lrp5tm3.2Mawa/Lrp5tm3.2Mawa
Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Lrp5tm1Grw/Lrp5tm1Grw,Sosttm1Paz/Sosttm1Paz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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| MP:0010872 | increased trabecular bone mass | "greater total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lrp5tm1Grw/Lrp5tm1Grw,Sosttm1Paz/Sosttm1Paz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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| MP:0010873 | decreased trabecular bone mass | "reduced total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Lrp5Gt(OST164883)Lex/Lrp5Gt(OST164883)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
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| MP:0010875 | increased bone volume | "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hivep3tm1Glm/Hivep3tm1Glm,Lrp5tm3.2Mawa/Lrp5tm3.2Mawa
Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Lrp5tm1Grw/Lrp5tm1Grw,Sosttm1Paz/Sosttm1Paz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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| MP:0010876 | decreased bone volume | "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Lrp5tm1Kry/Lrp5tm1Kry
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
Allelic Composition: Lrp5tm1Kry/Lrp5+
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
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| MP:0010961 | increased compact bone mass | |
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Allelic Composition: Lrp5tm1Grw/Lrp5tm1Grw,Sosttm1Paz/Sosttm1Paz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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| MP:0010962 | decreased compact bone mass | |
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Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Lrp5Gt(OST164883)Lex/Lrp5Gt(OST164883)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Lrp5tm1Jfh/Lrp5tm1Jfh,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
Allelic Composition: Lrp5tm1Kry/Lrp5tm1Kry
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
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| MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Lrp5tm1.1Vari/Lrp5tm1.1Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Lrp5tm1.2Vari/Lrp5tm1.2Vari,Lrp6tm1.1Vari/Lrp6tm1.1Vari,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0011099 | complete lethality throughout fetal growth and development | "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Igk-V21-Bax)1967Bvn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N
Allelic Composition: Lrp5tm1Jfh/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
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| MP:0011102 | partial embryonic lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
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Allelic Composition: Lrp5tm1Kry/Lrp5tm1Kry,Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129 * C57BL/6 * CBA
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| MP:0011965 | decreased total retina thickness | "decreased width of the retina through the center plane" [MGI:csmith] |
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Allelic Composition: Lrp5tm1Dgen/Lrp5tm1Dgen
Genetic Background: B6.129P2-Lrp5tm1Dgen/J
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| MP:0012035 | abnormal b-wave shape | "any anomaly in the graphical representation of the b wave in the electroretinogram; the b wave represents the health of the inner layers of the retina, including the ON bipolar cells and the Muller cells" [http://webvision.med.utah.edu, MGI:csmith] |
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Allelic Composition: Lrp5tm1Dgen/Lrp5tm1Dgen
Genetic Background: B6.129P2-Lrp5tm1Dgen/J
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| MP:0012139 | increased forebrain size | "greater than average size of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853] |
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Allelic Composition: Lrp5tm1Jfh/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
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| MP:0012143 | decreased a wave amplitude | "reduction in the size (height or maximum displacement) of the a wave as measured in the electroretinogram" [MGI:csmith] |
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Allelic Composition: Lrp5tvrm111B/Lrp5tvrm111B
Genetic Background: C57BL/6J-Lrp5tvrm111b/Pjn
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| MP:0012144 | decreased b wave amplitude | "reduction in the size (height or maximum displacement) of the b wave as measured in the electroretinogram" [MGI:csmith] |
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Allelic Composition: Lrp5tvrm111B/Lrp5tvrm111B
Genetic Background: C57BL/6J-Lrp5tvrm111b/Pjn
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| MP:0013207 | absent endoderm | "absence of the innermost of the three primary germ layers of the embryo (the others being mesoderm and ectoderm) that is formed during gastrulation" [MGI:anna] |
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Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Igk-V21-Bax)1967Bvn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N
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| MP:0013618 | decreased areal bone mineral density | "reduction of the mineral mass per unit area of bone, the hard, rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; expressed as the amount of mineral per area cm^2 of bone (usually in g/cm^2), with results generated from Dual-energy X-ray absorptiometry (DXA or DEXA) tests" [PMID:12730800, PMID:17481978] |
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Allelic Composition: Lrp5tvrm111B/Lrp5tvrm111B
Genetic Background: C57BL/6J-Lrp5tvrm111b/Pjn
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| MP:0013639 | decreased bone stiffness | "decrease in material stiffness (N/mm) during elastic deformation" [MGI:jwhite] |
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Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas
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| MP:0013640 | increased bone stiffness | "increase in material stiffness (N/mm) during elastic deformation" [MGI:jwhite] |
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Allelic Composition: Lrp5tm1Grw/Lrp5tm1Grw,Sosttm1Paz/Sosttm1Paz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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| MP:0013925 | abnormal vascular plexus formation | |
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Allelic Composition: Lrp5tm1Dgen/Lrp5tm1Dgen
Genetic Background: B6.129P2-Lrp5tm1Dgen/J
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| MP:0014179 | abnormal blood-retinal barrier function | "anomaly in the function of the part of the blood-ocular barrier that consists of cells that are joined tightly together to prevent certain substances from entering the tissue of the retina; the BRB consists of non-fenestrated capillaries of the retinal circulation and tight-junctions between retinal epithelial cells preventing passage of large molecules from choriocapillaris into the retina; the BRB barrier becomes more leaky in patients with diabetic retinopathy" [https://en.wikipedia.org/wiki/Blood%E2%80%93retinal_barrier] |
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Allelic Composition: Lrp5tvrm111B/Lrp5tvrm111B
Genetic Background: C57BL/6J-Lrp5tvrm111b/Pjn
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| MP:0020039 | increased bone ossification | "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597] |
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Allelic Composition: Lrp5tm3(Lrp5*)Kry/Lrp5tm3(Lrp5*)Kry,Tg(Vil-cre)20Syr/0
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0020040 | decreased bone ossification | "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597] |
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Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Lrp5Gt(OST164883)Lex/Lrp5Gt(OST164883)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
Allelic Composition: Lrp5tm2Kry/Lrp5tm2Kry,Tg(Vil-cre)20Syr/0
Genetic Background: involves: C57BL/6 * DBA/2
Allelic Composition: Lrp5tm2Kry/Lrp5+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: C57BL/6 * DBA/2
Allelic Composition: Creb1tm3Gsc/Creb1+,Lrp5tm1Kry/Lrp5+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB
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| MP:0020137 | decreased bone mineralization | "decrease in the rate at which minerals are deposited into bone" [] |
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Allelic Composition: Destm1Cba/Destm1Cba
Genetic Background: involves: 129S2/SvPas
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| MP:0030281 | thin parietal bone | "reduced thickness of the paired membranous bones located between the frontal and occipital bones that are large, curved and quadrilateral in outline, articulate with each other at the midline in the sagittal suture, and form most of the superior and lateral aspects of the cranium" [MGI:anna] |
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Allelic Composition: Lrp5tm1Jsak/Lrp5tm1Jsak
Genetic Background: involves: C57BL/6 * CBA
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| MP:0030439 | decreased osteoblast proliferation | "reduction in the expansion rate of osteoblasts by cell division; osteoblasts are skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell" [MGI:anna] |
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Allelic Composition: Lrp5tm2Kry/Lrp5tm2Kry,Tg(Vil-cre)20Syr/0
Genetic Background: involves: C57BL/6 * DBA/2
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