ENSMUSG00000027253


Mus musculus

Features
Gene ID: ENSMUSG00000027253
  
Biological name :Lrp4
  
Synonyms : Low-density lipoprotein receptor-related protein 4 / Lrp4 / Q8VI56
  
Possible biological names infered from orthology : LDL receptor related protein 4 / O75096
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E1
Gene start: 91457511
Gene end: 91513779
  
Corresponding Affymetrix probe sets: 10473880 (MoGene1.0st)   1426288_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028689
NCBI entrez gene - 228357     See in Manteia.
MGI - MGI:2442252
RefSeq - NM_172668
RefSeq - XM_006499243
RefSeq Peptide - NP_766256
swissprot - Q8VI56
Ensembl - ENSMUSG00000027253
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01071171.1ENSDARG00000116353Danio rerio
 LRP4ENSGALG00000032181Gallus gallus
 LRP4ENSG00000134569Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrp2 / A2ARV4 / low density lipoprotein receptor-related protein 2 / P98164* / LDL receptor related protein 2*ENSMUSG0000002707036
Lrp1 / LDL receptor related protein 1 / Q07954*ENSMUSG0000004024936
Lrp1b / LDL receptor related protein 1B / Q9NZR2*ENSMUSG0000004925234
Lrp6 / LDL receptor related protein 6 / O75581*ENSMUSG0000003020131
Lrp5 / Q91VN0 / Low-density lipoprotein receptor-related protein 5 / O75197* / LDL receptor related protein 5*ENSMUSG0000002491331
Gm19410ENSMUSG0000010937218
Ldlr / P35951 / Low-density lipoprotein receptor / P01130*ENSMUSG0000003219316
Vldlr / P98156 / very low density lipoprotein receptor / P98155*ENSMUSG0000002492416
Lrp8 / Q924X6 / Low-density lipoprotein receptor-related protein 8 / Q14114* / LDL receptor related protein 8*ENSMUSG0000002861314


Protein motifs (from Interpro)
Interpro ID Name
 IPR000033  LDLR class B repeat
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR026823  Complement Clr-like EGF domain
 IPR030799  Low-density lipoprotein receptor-related protein 4
 IPR036055  LDL receptor-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001932 regulation of protein phosphorylation IMP
 biological_processGO:0001942 hair follicle development IMP
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008104 protein localization IMP
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0009954 proximal/distal pattern formation IMP
 biological_processGO:0016055 Wnt signaling pathway IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IDA
 biological_processGO:0030279 negative regulation of ossification IEA
 biological_processGO:0030326 embryonic limb morphogenesis IMP
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IMP
 biological_processGO:0042733 embryonic digit morphogenesis IMP
 biological_processGO:0043113 receptor clustering IMP
 biological_processGO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification IBA
 biological_processGO:0048513 animal organ development IEA
 biological_processGO:0048813 dendrite morphogenesis IEA
 biological_processGO:0048856 anatomical structure development IMP
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0050771 negative regulation of axonogenesis IMP
 biological_processGO:0050808 synapse organization IEA
 biological_processGO:0051124 synaptic growth at neuromuscular junction IDA
 biological_processGO:0051290 protein heterotetramerization IEA
 biological_processGO:0060173 limb development IEA
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0071340 skeletal muscle acetylcholine-gated channel clustering IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0097104 postsynaptic membrane assembly IMP
 biological_processGO:0097105 presynaptic membrane assembly IMP
 biological_processGO:1901631 positive regulation of presynaptic membrane organization IDA
 biological_processGO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016600 flotillin complex IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031594 neuromuscular junction IDA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043235 receptor complex IBA
 cellular_componentGO:0097060 synaptic membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017147 Wnt-protein binding IBA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA
 molecular_functionGO:0034185 apolipoprotein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0042813 Wnt-activated receptor activity IBA
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lrp4mitt/Lrp4mitt
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Slc8a1tm1Sjc/Slc8a1tm1Sjc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
Show

Allelic Composition: Lrp4mitt/Lrp4mitt
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4tm2Her/Lrp4tm2Her
Genetic Background: involves: 129S/SvEv * C57BL

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lrp4tm2Her/Lrp4tm2Her
Genetic Background: involves: 129S/SvEv * C57BL

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Slc8a1tm1Sjc/Slc8a1tm1Sjc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Slc8a1tm1Sjc/Slc8a1tm1Sjc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc8a1tm1Sjc/Slc8a1tm1Sjc
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lrp4dan/Lrp4dan
Genetic Background: 129S2/SvPas-Lrp4dan

Allelic Composition: Lrp4mdig/Lrp4mdig
Genetic Background: involves: 129S2/SvPas * DBA/1LacJ

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ednrbs/Ednrbs,Lystbg-slt/Lystbg-slt
Genetic Background: involves: C57BL/10Ch * Y257/Ch

Allelic Composition: Lrp4dan/Lrp4dan
Genetic Background: 129S2/SvPas-Lrp4dan

Allelic Composition: Lrp4mdig/Lrp4mdig
Genetic Background: involves: 129S2/SvPas * DBA/1LacJ

Allelic Composition: Lrp4mitt/Lrp4mitt
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Lrp4mitt/Lrp4mitt
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mdig-2J/Lrp4mdig-2J
Genetic Background: involves: C3H/HeSnJ * SB/LeJ

 MP:0000568 ectopic digits "positional abnormality of a digit" [J:50311]
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Allelic Composition: Lrp4mitt/Lrp4mitt
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lrp4mitt/Lrp4mitt
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

 MP:0000580 deformed nails "atypical shape or size of the nails" [J:45400]
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Allelic Composition: Lrp4dan/Lrp4dan
Genetic Background: 129S2/SvPas-Lrp4dan

Allelic Composition: Lrp4mdig/Lrp4mdig
Genetic Background: involves: 129S2/SvPas * DBA/1LacJ

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Lrp4mitt/Lrp4mitt
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4tm1.1Line/Lrp4tm1.1Line,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Lrp4tm1.1Line/Lrp4tm1.1Line,Mnx1tm4(cre)Tmj/Mnx1+,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * C57BL/6J * SJL

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Lrp4mitt/Lrp4mitt
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4tm2Her/Lrp4tm2Her
Genetic Background: involves: 129S/SvEv * C57BL

Allelic Composition: Lrp4tm1.1Line/Lrp4tm1.1Line,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Lrp4tm1.1Line/Lrp4tm1.1Line,Mnx1tm4(cre)Tmj/Mnx1+,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Lrp4tm2Her/Lrp4tm2Her
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

Allelic Composition: Lrp4tm1Her/Lrp4tm1Her
Genetic Background: involves: 129S/SvEvBrd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Apptm1Dbo/Apptm1Dbo,Lrp4tm1Her/Lrp4tm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Lrp4tm1Her/Lrp4tm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

 MP:0001054 failure of presynaptic differentiation "inability of nerve terminals to find target and/or form terminal arbors for synaptic transmission" [J:61509]
Show

Allelic Composition: Lrp4mitt/Lrp4mitt
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4tm2Her/Lrp4tm2Her
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0001055 failure of postsynaptic differentiation "inability of an effector cell to form a differentiated postsynaptic membrane in response to innervation" [J:61509]
Show

Allelic Composition: Lrp4mitt/Lrp4mitt
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4tm2Her/Lrp4tm2Her
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0001078 abnormal phrenic nerve "malformed or misprojection of motor and sensory neuron axons to the diaphragm and other tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Lrp4mitt/Lrp4mitt
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lrp4mitt/Lrp4mitt
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Angptl3tm1Kfuj/Angptl3tm1Kfuj
Genetic Background: B6.129S1-Angptl3tm1Kfuj

Allelic Composition: Lrp4mdig-3J/Lrp4mdig-3J
Genetic Background: B6.Cg-Lrp4mdig-3J/GrsrJ

 MP:0001382 abnormal nursing "females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Angptl3tm1Kfuj/Angptl3tm1Kfuj
Genetic Background: B6.129S1-Angptl3tm1Kfuj

Allelic Composition: Lrp4mdig/Lrp4mdig
Genetic Background: involves: 129S2/SvPas * DBA/1LacJ

 MP:0001404 no spontaneous movement "failure to make any change in position or posture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Lrp4mitt/Lrp4mitt
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Angptl3tm1Kfuj/Angptl3tm1Kfuj
Genetic Background: B6.129S1-Angptl3tm1Kfuj

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Angptl3tm1Kfuj/Angptl3tm1Kfuj
Genetic Background: B6.129S1-Angptl3tm1Kfuj

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Lrp4mitt/Lrp4mitt
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4tm1.1Line/Lrp4tm1.1Line,Mnx1tm4(cre)Tmj/Mnx1+,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * C57BL/6J * SJL

 MP:0001676 abnormal apical ectodermal ridge "malformation of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
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Allelic Composition: Lrp4mitt/Lrp4mitt
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

 MP:0001678 thick apical ectodermal ridge "increase in the thickness of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
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Allelic Composition: Slc8a1tm1Sjc/Slc8a1tm1Sjc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001731 abnormal postnatal growth "anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]
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Allelic Composition: Slc8a1tm1Sjc/Slc8a1tm1Sjc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Lrp4mdig-3J/Lrp4mdig-3J
Genetic Background: B6.Cg-Lrp4mdig-3J/GrsrJ

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Lrp4mitt/Lrp4mitt
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lrp4tm1Her/Lrp4tm1Her
Genetic Background: involves: 129S/SvEvBrd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Apptm1Dbo/Apptm1Dbo,Lrp4tm1Her/Lrp4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lrp4mitt/Lrp4mitt
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lrp4mdig-3J/Lrp4mdig-3J
Genetic Background: B6.Cg-Lrp4mdig-3J/GrsrJ

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc8a1tm1Sjc/Slc8a1tm1Sjc
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lrp4mitt/Lrp4mitt
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mdig-3J/Lrp4mdig-3J
Genetic Background: B6.Cg-Lrp4mdig-3J/GrsrJ

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptch1tm1Zim/Ptch1tm1Zim
Genetic Background: involves: 129/Sv

 MP:0002544 brachydactyly "abnormally short digits" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ednrbs/Ednrbs,Lystbg-slt/Lystbg-slt
Genetic Background: involves: C57BL/10Ch * Y257/Ch

Allelic Composition: Lrp4dan/Lrp4dan
Genetic Background: 129S2/SvPas-Lrp4dan

Allelic Composition: Lrp4mdig/Lrp4mdig
Genetic Background: involves: 129S2/SvPas * DBA/1LacJ

Allelic Composition: Lrp4mdig-3J/Lrp4mdig-3J
Genetic Background: B6.Cg-Lrp4mdig-3J/GrsrJ

 MP:0002576 abnormal enamel morphology "malformation of the hard outer coating of the exposed portion of the tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:71126, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr3c1tm2Gsc/Nr3c1tm2Gsc,Tg(Runx2-icre)1Jtuc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002914 abnormal endplate potential activity "defect in the excitatory response of peripheral synapses to stimulation; these amplitudes are larger than central synapse potentials" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Lrp4tm1.1Line/Lrp4tm1.1Line,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * SJL

 MP:0003604 single kidney 
Show

Allelic Composition: Lrp4mitt/Lrp4mitt
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4tm2Her/Lrp4tm2Her
Genetic Background: involves: 129S/SvEv * C57BL

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Lrp4mitt/Lrp4mitt
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Lrp4mitt/Lrp4mitt
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

 MP:0004083 polysyndactyly "greater than 5 digits present on an autopod with interdigital webbing also present" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Lrp4dan/Lrp4dan
Genetic Background: 129S2/SvPas-Lrp4dan

Allelic Composition: Lrp4mdig/Lrp4mdig
Genetic Background: involves: 129S2/SvPas * DBA/1LacJ

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lrp4mdig-3J/Lrp4mdig-3J
Genetic Background: B6.Cg-Lrp4mdig-3J/GrsrJ

 MP:0004639 fused metacarpal bones "improper union of one or more of the five bones of the forepaws/hands that articulate proximally with the carpal bones and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lrp4mitt/Lrp4mitt
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

 MP:0004642 fused metatarsal bones "improper union of the five bones of the hindpaws/feet that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lrp4mitt/Lrp4mitt
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

 MP:0004835 abnormal miniature endplate potential "defect in the size or duration of spontaneous currents detected in PNS postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp4tm1.1Line/Lrp4tm1.1Line,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * SJL

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp4tm2Her/Lrp4tm2Her
Genetic Background: involves: 129S/SvEv * C57BL

 MP:0005358 abnormal incisor morphology "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
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Allelic Composition: Slc8a1tm1Sjc/Slc8a1tm1Sjc
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lrp4tm1Her/Lrp4tm1Her
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Lrp4tm2Her/Lrp4tm2Her
Genetic Background: involves: 129S/SvEv

 MP:0006032 abnormal ureteric bud morphology "anomaly in the formation or development of the ureteric bud that with the metanephric mesenchyme gives rise to the kidneys " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
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Allelic Composition: Lrp4tm2Her/Lrp4tm2Her
Genetic Background: involves: 129S/SvEv * C57BL

 MP:0006369 supernumerary incisors "more than a pair, top and/or bottom, of the long pointed teeth that are the most anterior and prominent in the jaw" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp4tm1Her/Lrp4tm1Her
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Lrp4tm2Her/Lrp4tm2Her
Genetic Background: involves: 129S/SvEv

Allelic Composition: Lrp4mdig-2J/Lrp4mdig-2J
Genetic Background: involves: C3H/HeSnJ * SB/LeJ

 MP:0008730 fused phalanges "anomaly of the long bones of the digits resulting in some or all the bones being joined together" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp4mdig-3J/Lrp4mdig-3J
Genetic Background: B6.Cg-Lrp4mdig-3J/GrsrJ

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apptm1Dbo/Apptm1Dbo,Lrp4tm1Her/Lrp4tm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

 MP:0010983 abnormal ureteric bud invasion "any anomaly in the process in which the ureteric bud grows into the metanephric mesenchyme, and contributes to the formation of the metanephros" [PMID:19828308]
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Allelic Composition: Lrp4tm2Her/Lrp4tm2Her
Genetic Background: involves: 129S/SvEv * C57BL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Lrp4tm1.1Line/Lrp4tm1.1Line,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Lrp4tm1Her/Lrp4tm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Lrp4mitt/Lrp4mitt
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4tm2Her/Lrp4tm2Her
Genetic Background: involves: 129S/SvEv * C57BL

Allelic Composition: Lrp4tm1.1Line/Lrp4tm1.1Line,Mnx1tm4(cre)Tmj/Mnx1+,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * C57BL/6J * SJL

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Lrp4tm2Her/Lrp4tm2Her
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Slc8a1tm1Sjc/Slc8a1tm1Sjc
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Apptm1Dbo/Apptm1Dbo,Lrp4tm1Her/Lrp4tm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

 MP:0011298 ureter hypoplasia "underdevelopment or reduced size of the ureter, usually due to a reduced number of cells" [MGI:anna]
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Allelic Composition: Lrp4tm2Her/Lrp4tm2Her
Genetic Background: involves: 129S/SvEv * C57BL

 MP:0011387 absent metanephric mesenchyme "absence of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing metanephros; normally, interactions between the ureteric bud and the metanephric mesenchyme lead to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [MGI:anna]
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Allelic Composition: Lrp4tm2Her/Lrp4tm2Her
Genetic Background: involves: 129S/SvEv * C57BL

 MP:0013785 abnormal mammary gland bud morphology "any structural anomaly of the morphologically distinct bulb of epithelial cells formed once each mammary placode expands and invaginates into the underlying mesenchyme; in mouse embryos at E12.5, each epithelial bud with its contiguous mesenchyme is elevated above the surrounding ectoderm as a knob or dome; at E13.5, the buds sink into the underlying dermal mesenchyme, and by E14.5 they can no longer be detected externally; in female mouse embryos, five pairs of anlagen or buds are formed along the mammary line between E12.5 and E14.5 by proliferation of basal epidermal cells; while further mammary development is temporarily arrested in females, androgen receptor activation in male embryos causes degeneration of the buds between E13.5 and E15.5; in female mice, further development is resumed at around E15.5 when each bud elongates to form a mammary cord (sprout), invading the underlying fat pad precursor" [http://www.informatics.jax.org/greenbook/frames/frame13.shtml, MGI:Anna, PMID:12558599]
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Allelic Composition: Lrp4mitt/Lrp4mitt
Genetic Background: involves: C57BL/6

Allelic Composition: Lrp4mte/Lrp4mte
Genetic Background: involves: C57BL/6

 MP:0030457 abnormal molar cusp morphology "any structural anomaly of an elevation or mound on the crown of a molar tooth making up a part of the occlusal (masticatory) surface" [https://medical-dictionary.thefreedictionary.com/cusp+of+tooth, MGI:anna]
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Allelic Composition: Lrp4tm2Her/Lrp4tm2Her
Genetic Background: involves: 129S/SvEv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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