ENSDARG00000006921


Danio rerio

Features
Gene ID: ENSDARG00000006921
  
Biological name :lrp5
  
Synonyms : low density lipoprotein receptor-related protein 5 / lrp5
  
Possible biological names infered from orthology : LDL receptor related protein 5 / O75197 / Q91VN0
  
Species: Danio rerio
  
Chr. number: 25
Strand: -1
Band:
Gene start: 10640623
Gene end: 10769039
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000108864
Ensembl peptide - ENSDARP00000146818
Ensembl peptide - ENSDARP00000149886
NCBI entrez gene - 568518     See in Manteia.
RefSeq - NM_001177458
RefSeq Peptide - NP_001170929
swissprot - F1QTJ4
ZFIN ID - ZDB-GENE-050518-2
Ensembl - ENSDARG00000006921
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LRP5ENSGALG00000029533Gallus gallus
 LRP5ENSG00000162337Homo sapiens
 Lrp5ENSMUSG00000024913Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lrp6 / low density lipoprotein receptor-related protein 6 / O75581* / LDL receptor related protein 6*ENSDARG0000010014337
lrp1aa / low density lipoprotein receptor-related protein 1Aa / LRP1* / Q07954* / LDL receptor related protein 1*ENSDARG0000009782732
lrp1ab / low density lipoprotein receptor-related protein 1Ab / LRP1* / Q07954* / LDL receptor related protein 1*ENSDARG0000002914632
lrp2a / low density lipoprotein receptor-related protein 2a / LRP2* / P98164* / A2ARV4* / LDL receptor related protein 2* / low density lipoprotein receptor-related protein 2*ENSDARG0000010250632
lrp2b / low density lipoprotein receptor-related protein 2bENSDARG0000000790631
lrp1bb / low density lipoprotein receptor-related protein 1Bb / LRP1B* / Q9NZR2* / LDL receptor related protein 1B*ENSDARG0000006151729
lrp1ba / low density lipoprotein receptor-related protein 1Ba / LRP1B* / Q9NZR2* / LDL receptor related protein 1B*ENSDARG0000000478926
CABZ01071171.1 / Danio rerio low density lipoprotein receptor-related protein 4 (lrp4), mRNA. / LRP4* / Q8VI56* / O75096* / LDL receptor related protein 4* / Low-density lipoprotein recepto...ENSDARG0000011635321
si:dkey-88l16.3 / Gm19410*ENSDARG0000009405511
lrp1ba / low density lipoprotein receptor-related protein 1Ba / Gm19410*ENSDARG0000009417110
lrp13 / low-density lipoprotein receptor related-protein 13 / Gm19410*ENSDARG0000002347910
ldlrb / low density lipoprotein receptor b / LDLR* / P35951* / P01130* / low density lipoprotein receptor*ENSDARG000000267599
lrp8 / low density lipoprotein receptor-related protein 8, apolipoprotein e receptor / Q14114* / Q924X6* / LDL receptor related protein 8* / Low-density lipoprotein receptor-related protein 8 *ENSDARG000000700749
vldlr / very low density lipoprotein receptor / P98155* / P98156*ENSDARG000000062579
ldlra / low density lipoprotein receptor a / LDLR* / P35951* / P01130* / low density lipoprotein receptor*ENSDARG000000294768


Protein motifs (from Interpro)
Interpro ID Name
 IPR000033  LDLR class B repeat
 IPR000742  EGF-like domain
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0001889 liver development IMP
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0032474 otolith morphogenesis IMP
 biological_processGO:0035676 anterior lateral line neuromast hair cell development IMP
 biological_processGO:0035677 posterior lateral line neuromast hair cell development IMP
 biological_processGO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification IBA
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0060059 embryonic retina morphogenesis in camera-type eye IBA
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IMP
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IBA
 molecular_functionGO:0017147 Wnt-protein binding IBA
 molecular_functionGO:0042813 Wnt-activated receptor activity IBA


Pathways (from Reactome)
Pathway description
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Regulation of FZD by ubiquitination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain morphology , abnormal
Show

 ZFA:0000029 hindbrain hindbrain decreased distribution , abnormal
hindbrain canonical Wnt signaling pathway decreased process quality , abnormal
hindbrain increased distribution , abnormal
hindbrain dorsal region mislocalised , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary decreased distribution , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle decreased size , abnormal
otic vesicle cell proliferation decreased occurrence , abnormal
Show

 ZFA:0000069 rhombomere 6 rhombomere 6 mislocalised , abnormal
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 ZFA:0000077 tail bud tail bud decreased distribution , abnormal
Show

 ZFA:0000110 fourth ventricle fourth ventricle swollen , abnormal
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 ZFA:0000123 liver liver decreased size , abnormal
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 ZFA:0000217 inner ear inner ear morphology , abnormal
Show

 ZFA:0000243 neuromast neuromast decreased size , abnormal
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 ZFA:0000737 cranium cranium lacks parts or has fewer parts of type ceratobranchial cartilage , abnormal
cranium malformed , abnormal
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 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast decreased amount , abnormal
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 ZFA:0001094 whole organism whole organism decreased amount , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage orientation ceratohyal cartilage , abnormal
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 ZFA:0001517 ceratobranchial 2 cartilage ceratobranchial 2 cartilage aplastic , abnormal
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 ZFA:0001518 ceratobranchial 3 cartilage ceratobranchial 3 cartilage aplastic , abnormal
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 ZFA:0001519 ceratobranchial 4 cartilage ceratobranchial 4 cartilage aplastic , abnormal
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 ZFA:0001520 ceratobranchial 1 cartilage ceratobranchial 1 cartilage aplastic , abnormal
ceratobranchial 1 cartilage hypoplastic , abnormal
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 ZFA:0001617 otolith otolith absent , abnormal
otolith decreased amount , abnormal
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 ZFA:0009003 cranial neural crest cell cranial neural crest cell mislocalised , abnormal
cranial neural crest cell decreased distribution , abnormal
cranial neural crest cell decreased amount , abnormal
cranial neural crest cell neural crest cell migration decreased process quality , abnormal
cranial neural crest cell canonical Wnt signaling pathway decreased process quality , abnormal
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 ZFA:0009363 neuromast support cell neuromast support cell decreased amount , abnormal
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 ZFA:0009367 neuromast hair cell neuromast hair cell stereocilium decreased length , abnormal
neuromast hair cell stereocilium decreased thickness , abnormal
neuromast hair cell stereocilium decreased amount , abnormal
neuromast hair cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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