ENSDARG00000029476


Danio rerio

Features
Gene ID: ENSDARG00000029476
  
Biological name :ldlra
  
Synonyms : ldlra / low density lipoprotein receptor a
  
Possible biological names infered from orthology : LDLR / low density lipoprotein receptor / P01130 / P35951
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 19299309
Gene end: 19323689
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000115492
Ensembl peptide - ENSDARP00000046296
NCBI entrez gene - 387529     See in Manteia.
RefSeq - NM_001030283
RefSeq - XM_005163870
RefSeq Peptide - NP_001025454
swissprot - E9QGD4
swissprot - Q7ZZT0
swissprot - F6P6T4
ZFIN ID - ZDB-GENE-031217-1
Ensembl - ENSDARG00000029476
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LDLRENSG00000130164Homo sapiens
 LdlrENSMUSG00000032193Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ldlrb / low density lipoprotein receptor b / LDLR* / P35951* / P01130* / low density lipoprotein receptor*ENSDARG0000002675945
lrp8 / low density lipoprotein receptor-related protein 8, apolipoprotein e receptor / Q14114* / Q924X6* / LDL receptor related protein 8* / Low-density lipoprotein receptor-related protein 8 *ENSDARG0000007007444
vldlr / very low density lipoprotein receptor / P98155* / P98156*ENSDARG0000000625742
lrp2b / low density lipoprotein receptor-related protein 2bENSDARG0000000790631
lrp1ba / low density lipoprotein receptor-related protein 1Ba / LRP1B* / Q9NZR2* / LDL receptor related protein 1B*ENSDARG0000000478930
lrp2a / low density lipoprotein receptor-related protein 2a / LRP2* / P98164* / A2ARV4* / LDL receptor related protein 2* / low density lipoprotein receptor-related protein 2*ENSDARG0000010250630
lrp1aa / low density lipoprotein receptor-related protein 1Aa / LRP1* / Q07954* / LDL receptor related protein 1*ENSDARG0000009782730
lrp1ab / low density lipoprotein receptor-related protein 1Ab / LRP1* / Q07954* / LDL receptor related protein 1*ENSDARG0000002914630
lrp1bb / low density lipoprotein receptor-related protein 1Bb / LRP1B* / Q9NZR2* / LDL receptor related protein 1B*ENSDARG0000006151729
si:dkey-88l16.3 / Gm19410*ENSDARG0000009405525
lrp13 / low-density lipoprotein receptor related-protein 13 / Gm19410*ENSDARG0000002347924
lrp5 / low density lipoprotein receptor-related protein 5 / O75197* / LDL receptor related protein 5*ENSDARG0000000692115
CABZ01071171.1 / Danio rerio low density lipoprotein receptor-related protein 4 (lrp4), mRNA. / LRP4* / Q8VI56* / O75096* / LDL receptor related protein 4* / Low-density lipoprotein recepto...ENSDARG000001163533
lrp6 / low density lipoprotein receptor-related protein 6 / O75581* / LDL receptor related protein 6*ENSDARG000001001432
lrp1ba / low density lipoprotein receptor-related protein 1Ba / Gm19410*ENSDARG000000941711


Protein motifs (from Interpro)
Interpro ID Name
 IPR000033  LDLR class B repeat
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0090118 receptor-mediated endocytosis involved in cholesterol transport IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005041 low-density lipoprotein particle receptor activity IMP
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Chylomicron clearance
LDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000123 liver liver increased size , abnormal
liver fatty , abnormal
liver increased amount , abnormal
liver decreased amount , abnormal
Show

 ZFA:0000180 caudal vein caudal vein lipid increased amount , abnormal
Show

 ZFA:0000477 posterior cardinal vein posterior cardinal vein has extra parts of type macrophage , abnormal
posterior cardinal vein fatty , abnormal
posterior cardinal vein vascular endothelium increased permeability , abnormal
posterior cardinal vein lipid oxidation increased occurrence , abnormal
Show

 ZFA:0001094 whole organism whole organism increased amount , abnormal
whole organism decreased amount , abnormal
whole organism cholesterol increased amount , abnormal
whole organism triglyceride increased amount , abnormal
Show

 ZFA:0005249 vasculature vasculature macrophage mislocalised , abnormal
vasculature lipid increased amount , abnormal
vasculature lipid amount , ameliorated
Show

 ZFA:0005654 blood plasma blood plasma cholesterol increased amount , abnormal
blood plasma triglyceride increased amount , abnormal
blood plasma low-density lipoprotein increased amount , abnormal
blood plasma very-low-density lipoprotein decreased amount , abnormal
blood plasma lipid amount , ameliorated
blood plasma lipid increased amount , abnormal
Show

 ZFA:0009111 hepatocyte hepatocyte cellular response to lipopolysaccharide disrupted , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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