ENSDARG00000102506


Danio rerio

Features
Gene ID: ENSDARG00000102506
  
Biological name :lrp2a
  
Synonyms : low density lipoprotein receptor-related protein 2a / lrp2a
  
Possible biological names infered from orthology : A2ARV4 / LDL receptor related protein 2 / low density lipoprotein receptor-related protein 2 / LRP2 / P98164
  
Species: Danio rerio
  
Chr. number: 9
Strand: 1
Band:
Gene start: 48415043
Gene end: 48672254
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000131232
Ensembl peptide - ENSDARP00000139062
swissprot - A0A0R4IAG0
swissprot - A0A0R4IVD8
ZFIN ID - ZDB-GENE-050119-2
Ensembl - ENSDARG00000102506
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LRP2ENSGALG00000010858Gallus gallus
 LRP2ENSG00000081479Homo sapiens
 Lrp2ENSMUSG00000027070Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lrp2b / low density lipoprotein receptor-related protein 2bENSDARG0000000790655
lrp1ab / low density lipoprotein receptor-related protein 1Ab / LRP1* / Q07954* / LDL receptor related protein 1*ENSDARG0000002914635
lrp1aa / low density lipoprotein receptor-related protein 1Aa / LRP1* / Q07954* / LDL receptor related protein 1*ENSDARG0000009782734
lrp1bb / low density lipoprotein receptor-related protein 1Bb / LRP1B* / Q9NZR2* / LDL receptor related protein 1B*ENSDARG0000006151733
lrp1ba / low density lipoprotein receptor-related protein 1Ba / LRP1B* / Q9NZR2* / LDL receptor related protein 1B*ENSDARG0000000478926
lrp5 / low density lipoprotein receptor-related protein 5 / O75197* / LDL receptor related protein 5*ENSDARG0000000692111
lrp1ba / low density lipoprotein receptor-related protein 1Ba / Gm19410*ENSDARG0000009417111
si:dkey-88l16.3 / Gm19410*ENSDARG0000009405510
lrp13 / low-density lipoprotein receptor related-protein 13 / Gm19410*ENSDARG000000234798
CABZ01071171.1 / Danio rerio low density lipoprotein receptor-related protein 4 (lrp4), mRNA. / LRP4* / Q8VI56* / O75096* / LDL receptor related protein 4* / Low-density lipoprotein recepto...ENSDARG000001163537
lrp8 / low density lipoprotein receptor-related protein 8, apolipoprotein e receptor / Q14114* / Q924X6* / LDL receptor related protein 8* / Low-density lipoprotein receptor-related protein 8 *ENSDARG000000700747
ldlrb / low density lipoprotein receptor b / LDLR* / P35951* / P01130* / low density lipoprotein receptor*ENSDARG000000267596
lrp6 / low density lipoprotein receptor-related protein 6 / O75581* / LDL receptor related protein 6*ENSDARG000001001436
vldlr / very low density lipoprotein receptor / P98155* / P98156*ENSDARG000000062576
ldlra / low density lipoprotein receptor a / LDLR* / P35951* / P01130* / low density lipoprotein receptor*ENSDARG000000294766


Protein motifs (from Interpro)
Interpro ID Name
 IPR000033  LDLR class B repeat
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR026823  Complement Clr-like EGF domain
 IPR032485  Domain of unknown function DUF5050


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis IMP
 biological_processGO:0070293 renal absorption IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
Vitamin D (calciferol) metabolism
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer neuron increased amount , abnormal
retinal ganglion cell layer neuron sparse , abnormal
retinal ganglion cell layer hypotrophic , abnormal
Show

 ZFA:0000035 lens lens increased diameter , abnormal
Show

 ZFA:0000046 retinal neural layer retinal neural layer decreased thickness , abnormal
retinal neural layer cell decreased mass density , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000107 eye eye increased size , abnormal
eye refractivity , abnormal
eye increased diameter , abnormal
eye variability of size , abnormal
eye protruding , abnormal
Show

 ZFA:0000119 retinal inner nuclear layer retinal inner nuclear layer hypotrophic , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct early endosome absent , abnormal
pronephric duct endosome absent , abnormal
pronephric duct recycling endosome membrane absent , abnormal
Show

 ZFA:0000151 pronephros pronephros edematous , abnormal
pronephros decreased functionality , abnormal
Show

 ZFA:0000152 retina retina apoptotic , abnormal
retina decreased thickness , abnormal
retina disorganized , abnormal
retina increased area , abnormal
retina proliferative , abnormal
retina increased size , abnormal
Show

 ZFA:0001127 visual system visual system decreased functionality , abnormal
Show

 ZFA:0001203 ciliary zone ciliary zone hypertrophic , abnormal
Show

 ZFA:0001289 ciliary marginal zone ciliary marginal zone neuronal stem cell decreased amount , abnormal
Show

 ZFA:0001464 retinal outer nuclear layer retinal outer nuclear layer hypotrophic , abnormal
Show

 ZFA:0001625 optic nerve head optic nerve head increased size , abnormal
optic nerve head increased diameter , abnormal
Show

 ZFA:0005561 vitreous vitreous increased size , abnormal
Show

 ZFA:0005566 anterior segment eye anterior segment eye aqueous humor increased pressure , abnormal
Show

 ZFA:0005567 posterior segment eye posterior segment eye increased depth , abnormal
Show

 ZFA:0009310 retinal ganglion cell retinal ganglion cell axon disorganized , abnormal
retinal ganglion cell axon circling , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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