ENSMUSG00000002985


Mus musculus

Features
Gene ID: ENSMUSG00000002985
  
Biological name :Apoe
  
Synonyms : Apoe / Apolipoprotein E / P08226
  
Possible biological names infered from orthology : P02649
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 19696109
Gene end: 19699188
  
Corresponding Affymetrix probe sets: 10560624 (MoGene1.0st)   1432466_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003066
Ensembl peptide - ENSMUSP00000134558
Ensembl peptide - ENSMUSP00000134622
Ensembl peptide - ENSMUSP00000133359
Ensembl peptide - ENSMUSP00000133302
Ensembl peptide - ENSMUSP00000133371
Ensembl peptide - ENSMUSP00000133447
Ensembl peptide - ENSMUSP00000134160
Ensembl peptide - ENSMUSP00000134429
NCBI entrez gene - 11816     See in Manteia.
MGI - MGI:88057
RefSeq - NM_009696
RefSeq - NM_001305819
RefSeq - NM_001305843
RefSeq - NM_001305844
RefSeq Peptide - NP_001292748
RefSeq Peptide - NP_033826
RefSeq Peptide - NP_001292773
RefSeq Peptide - NP_001292772
swissprot - Q3TXU4
swissprot - A0A1B0GX15
swissprot - G3UWN5
swissprot - G3UWW2
swissprot - G3UZM8
swissprot - P08226
Ensembl - ENSMUSG00000002985
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 apoeaENSDARG00000102004Danio rerio
 apoebENSDARG00000040295Danio rerio
 APOEENSG00000130203Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000074  Apolipoprotein A/E


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001937 negative regulation of endothelial cell proliferation ISO
 biological_processGO:0002021 response to dietary excess IMP
 biological_processGO:0006629 lipid metabolic process IGI
 biological_processGO:0006641 triglyceride metabolic process ISO
 biological_processGO:0006695 cholesterol biosynthetic process IBA
 biological_processGO:0006707 cholesterol catabolic process IMP
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IDA
 biological_processGO:0006898 receptor-mediated endocytosis ISO
 biological_processGO:0006979 response to oxidative stress IMP
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007263 nitric oxide mediated signal transduction ISO
 biological_processGO:0007616 long-term memory ISO
 biological_processGO:0008203 cholesterol metabolic process ISO
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010544 negative regulation of platelet activation ISO
 biological_processGO:0010873 positive regulation of cholesterol esterification IMP
 biological_processGO:0010875 positive regulation of cholesterol efflux ISO
 biological_processGO:0010877 lipid transport involved in lipid storage IMP
 biological_processGO:0010976 positive regulation of neuron projection development IMP
 biological_processGO:0010977 negative regulation of neuron projection development ISO
 biological_processGO:0015909 long-chain fatty acid transport ISO
 biological_processGO:0017038 protein import ISO
 biological_processGO:0019068 virion assembly ISO
 biological_processGO:0019433 triglyceride catabolic process IBA
 biological_processGO:0019934 cGMP-mediated signaling ISO
 biological_processGO:0030195 negative regulation of blood coagulation ISO
 biological_processGO:0030516 regulation of axon extension IBA
 biological_processGO:0030828 obsolete positive regulation of cGMP biosynthetic process ISO
 biological_processGO:0031102 neuron projection regeneration IBA
 biological_processGO:0032269 negative regulation of cellular protein metabolic process ISO
 biological_processGO:0032374 regulation of cholesterol transport IBA
 biological_processGO:0032462 regulation of protein homooligomerization ISO
 biological_processGO:0032489 regulation of Cdc42 protein signal transduction ISO
 biological_processGO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process ISO
 biological_processGO:0033344 cholesterol efflux ISO
 biological_processGO:0033700 phospholipid efflux IBA
 biological_processGO:0034372 very-low-density lipoprotein particle remodeling IMP
 biological_processGO:0034374 low-density lipoprotein particle remodeling IMP
 biological_processGO:0034375 high-density lipoprotein particle remodeling ISO
 biological_processGO:0034380 high-density lipoprotein particle assembly ISO
 biological_processGO:0034382 chylomicron remnant clearance ISO
 biological_processGO:0034384 high-density lipoprotein particle clearance ISO
 biological_processGO:0034447 very-low-density lipoprotein particle clearance ISO
 biological_processGO:0035641 locomotory exploration behavior ISO
 biological_processGO:0042157 lipoprotein metabolic process IEA
 biological_processGO:0042158 lipoprotein biosynthetic process IGI
 biological_processGO:0042159 lipoprotein catabolic process IMP
 biological_processGO:0042311 vasodilation IMP
 biological_processGO:0042632 cholesterol homeostasis ISO
 biological_processGO:0042982 amyloid precursor protein metabolic process ISO
 biological_processGO:0043407 negative regulation of MAP kinase activity ISO
 biological_processGO:0043524 negative regulation of neuron apoptotic process IBA
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration ISO
 biological_processGO:0043691 reverse cholesterol transport ISO
 biological_processGO:0044794 positive regulation by host of viral process ISO
 biological_processGO:0045541 negative regulation of cholesterol biosynthetic process ISO
 biological_processGO:0045807 positive regulation of endocytosis ISO
 biological_processGO:0046889 positive regulation of lipid biosynthetic process ISO
 biological_processGO:0048844 artery morphogenesis IGI
 biological_processGO:0050728 negative regulation of inflammatory response IGI
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity IBA
 biological_processGO:0051044 positive regulation of membrane protein ectodomain proteolysis ISO
 biological_processGO:0051246 regulation of protein metabolic process ISO
 biological_processGO:0051651 maintenance of location in cell IMP
 biological_processGO:0055088 lipid homeostasis IMP
 biological_processGO:0055089 fatty acid homeostasis ISO
 biological_processGO:0060999 positive regulation of dendritic spine development ISO
 biological_processGO:0061771 response to caloric restriction ISO
 biological_processGO:0070328 triglyceride homeostasis IMP
 biological_processGO:0072358 cardiovascular system development IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway ISO
 biological_processGO:0090181 regulation of cholesterol metabolic process ISO
 biological_processGO:0090209 negative regulation of triglyceride metabolic process IGI
 biological_processGO:0097006 regulation of plasma lipoprotein particle levels IMP
 biological_processGO:0097113 AMPA glutamate receptor clustering ISO
 biological_processGO:0097114 NMDA glutamate receptor clustering ISO
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:1900221 regulation of amyloid-beta clearance ISO
 biological_processGO:1900272 negative regulation of long-term synaptic potentiation ISO
 biological_processGO:1901215 negative regulation of neuron death ISO
 biological_processGO:1901628 positive regulation of postsynaptic membrane organization ISO
 biological_processGO:1901630 negative regulation of presynaptic membrane organization ISO
 biological_processGO:1902430 negative regulation of amyloid-beta formation ISO
 biological_processGO:1902952 positive regulation of dendritic spine maintenance ISO
 biological_processGO:1902995 positive regulation of phospholipid efflux ISO
 biological_processGO:1903002 positive regulation of lipid transport across blood brain barrier ISO
 biological_processGO:1905855 positive regulation of heparan sulfate binding ISO
 biological_processGO:1905860 positive regulation of heparan sulfate proteoglycan binding ISO
 biological_processGO:1905890 regulation of cellular response to very-low-density lipoprotein particle stimulus ISO
 biological_processGO:1905906 regulation of amyloid fibril formation ISO
 biological_processGO:2000822 regulation of behavioral fear response ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0034361 very-low-density lipoprotein particle ISO
 cellular_componentGO:0034362 low-density lipoprotein particle IDA
 cellular_componentGO:0034363 intermediate-density lipoprotein particle IBA
 cellular_componentGO:0034364 high-density lipoprotein particle ISO
 cellular_componentGO:0042627 chylomicron IBA
 cellular_componentGO:0072562 blood microparticle IBA
 cellular_componentGO:0106003 amyloid-beta complex ISO
 cellular_componentGO:1990777 lipoprotein particle ISO
 molecular_functionGO:0001540 amyloid-beta binding ISS
 molecular_functionGO:0005319 lipid transporter activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding ISO
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0015485 cholesterol binding IBA
 molecular_functionGO:0016209 antioxidant activity ISO
 molecular_functionGO:0017127 cholesterol transporter activity IDA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0046911 metal chelating activity ISO
 molecular_functionGO:0046983 protein dimerization activity ISO
 molecular_functionGO:0048156 tau protein binding ISO
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding IBA
 molecular_functionGO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity IMP
 molecular_functionGO:0070326 very-low-density lipoprotein particle receptor binding ISO
 molecular_functionGO:0071813 lipoprotein particle binding IDA


Pathways (from Reactome)
Pathway description
Scavenging by Class A Receptors
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Chylomicron assembly
Chylomicron remodeling
Chylomicron clearance
HDL remodeling
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0000048 abnormal stria vascularis "anomalous structure of the layer of highly vascularized pigmented granular cells on the outer wall of the cochlear duct" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Faslpr/Faslpr,Tnfrsf13cBcmd1/Tnfrsf13c+
Genetic Background: MRL.Cg-Tnfrsf13cBcmd1 Faslpr

 MP:0000136 abnormal microglial cell morphology "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]
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Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae,Tg(Thy1-APPSwDutIowa)BWevn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(Cyp21a1-Apoe)614Fet/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Apobec1tm1Chan/Apobec1tm1Chan,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lpltm1Sem/Lpltm1Sem
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apoetm1Bres/Apoetm1Bres
Genetic Background: B6.129P2-Apoetm1Bres

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: B6.129P2-Apoetm1Bres Esr1tm1Ksk

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Rraf/Apoetm1Rraf,Tg(Mx1-cre)29-4Her/0
Genetic Background: B6.Cg-Apoetm1Rraf Tg(Mx1-cre)29-4Her

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000181 abnormal circulating LDL cholesterol level "anomalous concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(APOC1)1Bres/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hdl5C57BL/6J/Hdl5C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hdlq86C3H/HeJ/Hdlq86C3H/HeJ
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hdlq86C3H/HeJ/?
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nhdlq11C3H/HeJ/Nhdlq11C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nhdlq11C3H/HeJ/Nhdlq11C3H/HeJ
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nhdlq12C3H/HeJ/Nhdlq12C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nhdlq12C57BL/6J/Nhdlq12C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pnhdlc1C57BL/6J/Pnhdlc1C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pnhdlc6C3H/HeJ/?
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lipgtm1Tq/Lipgtm1Tq
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her,Lrp1tm2Her/Lrp1tm2Her,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Khw/Apoetm1Khw
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Khw/Apoetm1Khw,Tg(Mx1-cre)29-4Her/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * SJL

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her,Lrp1tm2Her/Lrp1tm2Her,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

Allelic Composition: Apobec1tm1Rub/Apobec1tm1Rub,Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoa2tm1Bres/Apoa2tm1Bres,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Plgtm1Jld/Plgtm1Jld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss

Allelic Composition: Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Rag2tm1Fwa/Rag2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Crptm1Hjf/Crptm1Hjf
Genetic Background: B6.Cg-Crptm1Hjf Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000187 abnormal triglyceride level "anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ay/a,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cbstm1Unc/Cbstm1Unc,Tg(Mt1-CBS)25Waku/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr2tm1Ifc/Ccr2+,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: B6.Cg-Apoetm1Unc Ccr2tm1Ifc

 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000233 abnormal blood flow velocity "anomalous rate of flow of the blood through vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000248 macrocytosis "condition in which erythrocytes are larger than normal in size" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Timp1tm1Pds/Y
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129-Il1r1tm1Imx Apoetm1Unc

 MP:0000256 echinocytosis "a state in which the red blood cells have multiple small projections appearing over the cell circumference resembling a small burr or a sea urchin" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, J:82330, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: CryaaL1N/CryaaL1N,Tg(CAG-EGFP)1Osb/0
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Rag2tm1Fwa/Rag2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tnfrsf11btm1Eac/Tnfrsf11btm1Eac
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nfe2l2tm1Mym/Nfe2l2tm1Mym
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cxcl10tm1Adl/Cxcl10tm1Adl
Genetic Background: B6.129-Cxcl10tm1Adl Apoetm1Unc

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: CryaaL1N/CryaaL1N,Tg(CAG-EGFP)1Osb/0
Genetic Background: involves: C3H * C57BL/6

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: involves: C3H/He * KOR

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: involves: BALB/c * KOR

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: involves: C57BL/6 * KOR

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Gtf2ird1tm1Hrd/Gtf2ird1tm1Hrd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000604 amyloidosis "an accumulation of extracellular amyloid in tissues of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Del(11Cxcl16-Zmynd15)1Ifc/Del(11Cxcl16-Zmynd15)1Ifc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129S-Ldlrtm1Her Del(11Cxcl16-Zmynd15)1Ifc

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000639 abnormal adrenal gland morphology "malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61190]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0001200 thick skin "greater depth of skin " [J:47225]
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Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0001243 abnormal dermal layer morphology "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0001245 thick dermal layer "increased depth of the dermis" [J:65033]
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Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0001246 mixed cellular infiltration to dermis "gradual accumulation of mixed cell types in the dermis that are not normally found there" [J:65416]
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Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001259 abnormal body weight "anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Fbn1tm1Hcd/Fbn1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Faslpr/Faslpr,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129S7/SvEvBrd * MRL

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129-Apoetm1Unc Ifngtm1Ts

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Apobtm1Sgy/Apobtm1Sgy,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ay/a,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il1rntm1Dih/Il1rntm1Dih
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Rag2tm1Fwa/Rag2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Apoetm1Unc

Allelic Composition: Apoetm4Mae/Apoetm4Mae
Genetic Background: 129S6/SvEvTac-Apoetm4Mae

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cbstm1Unc/Cbstm1Unc,Tg(Mt1-CBS)25Waku/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Afg3l2Emv66/Afg3l2Emv66
Genetic Background: FVB.MEV2-Afg3l2Emv66

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001337 dry eyes "absence of natural or normal moisture in the eye" [J:53284]
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Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001345 meibomian gland atrophy "wasting of the sebaceous glands embedded in the tarsal plate of each eyelid resulting in reduced size" [J:65146]
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Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Cdc25atm1Kiyo/Cdc25a+,Tg(MMTV-Erbb2)NK1Mul/?
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(Eno2-APOE_i4)1Rabr/0
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

 MP:0001382 abnormal nursing "females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr3c1tm2Ljm/Nr3c1tm2Ljm,Tg(Camk2a-cre)T50Stl/?
Genetic Background: involves: 129 * BALB/c * C57BL/6 * CBA

 MP:0001388 abnormal stationary movement "altered ability or inability to change body posture or shift a body part" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(GFAP-APOE_i4)#Hol/0
Genetic Background: B6.Cg-Apoetm1Unc Tg(GFAP-APOE_i4)#Hol

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(GFAP-APOE_i3)37Hol/0
Genetic Background: B6.Cg-Apoetm1Unc Tg(GFAP-APOE_i3)37Hol

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(GFAP-APOE_i4)#Hol/0
Genetic Background: B6.Cg-Apoetm1Unc Tg(GFAP-APOE_i4)#Hol

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(GFAP-APOE_i3)37Hol/0
Genetic Background: B6.Cg-Apoetm1Unc Tg(GFAP-APOE_i3)37Hol

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Il10tm1.1Roer/Il10tm1.1Roer
Genetic Background: involves: 129P2/OlaHsd

 MP:0001413 abnormal response to new environment "altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(GFAP-APOE_i4)#Hol/0
Genetic Background: B6.Cg-Apoetm1Unc Tg(GFAP-APOE_i4)#Hol

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(GFAP-APOE_i3)37Hol/0
Genetic Background: B6.Cg-Apoetm1Unc Tg(GFAP-APOE_i3)37Hol

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(Eno2-APOE_i4)1Rabr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(Eno2-APOE_i3)1Rabr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: either: B6.129P2-Apoetm1Unc/J or (involves: 129P2/OlaHsd * C57BL/6J * ICR)

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(GFAP-APOE_i4)#Hol/0
Genetic Background: B6.Cg-Apoetm1Unc Tg(GFAP-APOE_i4)#Hol

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(GFAP-APOE_i3)37Hol/0
Genetic Background: B6.Cg-Apoetm1Unc Tg(GFAP-APOE_i3)37Hol

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(Eno2-APOE_i4)1Rabr/0
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(GFAP-APOE_i4)#Hol/0
Genetic Background: B6.Cg-Apoetm1Unc Tg(GFAP-APOE_i4)#Hol

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(GFAP-APOE_i3)37Hol/0
Genetic Background: B6.Cg-Apoetm1Unc Tg(GFAP-APOE_i3)37Hol

 MP:0001499 kindling "long-lasting epileptogenic changes induced by daily sub threshold electrical brain stimulation, induced model for epilepsy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45446]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abca1tm1Jdm/Abca1tm1Jdm,Abcg1tm1Dgen/Abcg1tm1Dgen,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(Cyp21a1-Apoe)619Fet/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0001548 hyperlipidemia "abnormally high concentration of lipids in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(APOC1)1Bres/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

Allelic Composition: Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lpltm1Sem/Lpltm1Sem
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apoetm1Rraf/Apoetm1Rraf,Tg(Mx1-cre)29-4Her/0
Genetic Background: B6.Cg-Apoetm1Rraf Tg(Mx1-cre)29-4Her

Allelic Composition: Apoetm1Khw/Apoetm1Khw,Tg(Mx1-cre)29-4Her/0
Genetic Background: B6.Cg-Apoetm1Khw Tg(Mx1-cre)29-4Her

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex
Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(APOC1)1Bres/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

Allelic Composition: Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss

Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apobec1tm1Ishi/Apobec1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat2tm1Far/Soat2tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lipgtm1Tq/Lipgtm1Tq
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her,Lrp1tm2Her/Lrp1tm2Her,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Khw/Apoetm1Khw
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Khw/Apoetm1Khw,Tg(Mx1-cre)29-4Her/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Apoetm1Unc/Apoe+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apobec1tm1Rub/Apobec1tm1Rub,Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apobec1tm1Chan/Apobec1tm1Chan,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lpltm1Sem/Lpltm1Sem
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae,Ldlrtm1(LDLR)Mae/Ldlr+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Spp1tm1Rit/Spp1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * SJL

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nfe2l2tm1Mym/Nfe2l2tm1Mym
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Apoetm4Mae/Apoetm4Mae
Genetic Background: 129S6/SvEvTac-Apoetm4Mae

Allelic Composition: Ay/a,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ptgdrtm1Dgen/Ptgdrtm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Klf15tm1Jain/Klf15tm1Jain
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apobtm1Sgy/Apobtm1Sgy,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat2tm1Far/Soat2tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hdlq86C3H/HeJ/Hdlq86C3H/HeJ
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hdlq86C3H/HeJ/?
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hdlq19C57BL/6J/Hdlq19C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hdlq91C3H/HeJ/?
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lipgtm1Tq/Lipgtm1Tq
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her,Lrp1tm2Her/Lrp1tm2Her,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apobec1tm1Rub/Apobec1tm1Rub,Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Crptm1Hjf/Crptm1Hjf
Genetic Background: B6.Cg-Crptm1Hjf Apoetm1Unc

Allelic Composition: Apoetm4Mae/Apoetm4Mae
Genetic Background: 129S6/SvEvTac-Apoetm4Mae

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ay/a,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001570 abnormal circulating enzyme level "aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Lrp1tm2Her/Lrp1tm2Her,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0001731 abnormal postnatal growth "anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae,Ldlrtm1(LDLR)Mae/Ldlr+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001744 hypersecretion of cortisol 
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA/J * SJL

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: CryaaL1N/CryaaL1N,Tg(CAG-EGFP)1Osb/0
Genetic Background: involves: C3H * C57BL/6

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001863 vascular inflammation "local accumulation of fluid, plasma proteins, and leukocytes in a blood vessel" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Klf15tm2Jain/Klf15tm2Jain,Tg(Tagln-cre)1Jjl/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001942 abnormal lung volume "anomaly in the amount of air that the lungs contain at various points of the respiratory cycle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Ntsr1tm2Dgen/Ntsr1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002065 abnormal fear/anxiety-related behavior "altered response in tests for fear or anxiety related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(GFAP-APOE_i4)#Hol/0
Genetic Background: B6.Cg-Apoetm1Unc Tg(GFAP-APOE_i4)#Hol

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae,Ldlrtm1(LDLR)Mae/Ldlr+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ay/a,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Plgtm1Jld/Plgtm1Jld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: involves: C3H/He * KOR

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: involves: BALB/c * KOR

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: involves: C57BL/6 * KOR

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(APPV717I)1130Kha/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Apoetm1Unc/Apoe+,Tg(APPV717I)1130Kha/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il1rntm1Dih/Il1rntm1Dih
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ttpatm1Far/Ttpatm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae,Ldlrtm1(LDLR)Mae/Ldlr+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lcattm1Hgc/Lcattm1Hgc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sftpa1tm1Kor/Sftpa1tm1Kor
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * C3H/HeN

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA/J * SJL

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Fastm1Osa/Fastm1Osa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0002164 abnormal gland physiology "altered glandular secretion not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae,Tg(Thy1-APPSwDutIowa)BWevn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(APPV717F)109Ili/0,Tg(GFAP-APOE_i2)14Hol/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(Eno2-APP*751)10Cord/0,Tg(GFAP-APOE_i3)37Hol/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(Eno2-APP*751)10Cord/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002191 abnormal artery morphology "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: CryaaL1N/CryaaL1N,Tg(CAG-EGFP)1Osb/0
Genetic Background: involves: C3H * C57BL/6

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(Eno2-APOE_i4)1Rabr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002323 resistance to hyperlipidemia "less likely than the norm to develop abnormally high levels of circulating lipids" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae,Ldlrtm1(LDLR)Mae/Ldlr+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

 MP:0002421 abnormal cell-mediated immunity "abnormal function of any adaptive immune response in which T cells play a main role " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mpztm1Msch/Mpz+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov
Genetic Background: Not Specified

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nfe2l2tm1Mym/Nfe2l2tm1Mym
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: MRL.Cg-Apoetm1Unc Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zdhhc13Gt(AC0492)Wtsi/Zdhhc13Gt(AC0492)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nos2tm1Lau/Nos2tm1Lau
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002643 poikilocytosis "blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her,Lrp1tm2Her/Lrp1tm2Her,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Apoetm1Unc

Allelic Composition: Angptl3tm1Lex/Angptl3tm1Lex,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Crptm1Hjf/Crptm1Hjf
Genetic Background: B6.Cg-Crptm1Hjf Apoetm1Unc

Allelic Composition: Apoetm1.1Mae/Apoetm1.1Mae,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Apoetm1.1Mae Tg(Fabp4-cre)1Rev

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

 MP:0002723 abnormal immune serum protein physiology "abnormal concentration or function of circulating immune proteins" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Apoetm1.1Mae/Apoetm1.1Mae,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Apoetm1.1Mae Tg(Fabp4-cre)1Rev

 MP:0002733 abnormal thermal nociception "abnormal capability to sense pain elicited by thermal stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129-Nos3tm1Plh Apoetm1Unc

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(Eno2-APOE_i4)1Rabr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: either: B6.129P2-Apoetm1Unc/J or (involves: 129P2/OlaHsd * C57BL/6J * ICR)

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Afg3l2Emv66/Afg3l2Emv66
Genetic Background: FVB.MEV2-Afg3l2Emv66

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)2Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129-Il1r1tm1Imx Apoetm1Unc

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0002865 increased growth rate "accelerated time to reach a developmental stage or stages" [J:32208, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myo6sv-4J/Myo6sv-4J
Genetic Background: 129S1/SvImJ-Myo6sv-4J/J

Allelic Composition: Albq4A/J/Albq4C57BL/6J,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: A/J * C57BL/6J

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Apoetm1Unc

Allelic Composition: Apoetm1.1Mae/Apoetm1.1Mae,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Apoetm1.1Mae Tg(Fabp4-cre)1Rev

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129-Nos3tm1Plh Apoetm1Unc

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0002964 aortic elastic tissue lesions "focal pathological changes in the elastic lamella of the muscular layer of the main trunk of the arterial system" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129 * C57BL/6

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Kuz/Ccr5tm1Kuz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Blck/Ccr5tm1Blck
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex
Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc

 MP:0003025 increased vascular smooth muscle contraction "greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129-Il1r1tm1Imx Apoetm1Unc

 MP:0003038 decreased infarction size "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0003075 response to CNS ischemic injury 
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Allelic Composition: Apoetm1(APOE)Kyan/Apoetm1(APOE)Kyan
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apoetm2(APOE)Sfu/Apoetm2(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd

 MP:0003137 abnormal impulse conducting system conduction "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129-Nos3tm1Plh Apoetm1Unc

 MP:0003149 abnormal tectorial membrane morphology "malformation, malfunction or absence of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells; sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair cell membrane potential, transducing sound into electrical signals" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:77634]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0003157 impaired muscle relaxation "reduced or absent ability of muscle to lengthen following contractions" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92510]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0003192 increased cholesterol efflux "greater level of removal of excess cholesterol from cells by an active transport pathway" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0003329 amyloid beta deposits 
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Clutm1Jakh/Clutm1Jakh,Tg(APPV717F)109Ili/Tg(APPV717F)109Ili
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(APPV717F)109Ili/Tg(APPV717F)109Ili
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(APPV717F)109Ili/0,Tg(GFAP-APOE_i4)#Hol/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(APPV717F)109Ili/0,Tg(GFAP-APOE_i3)37Hol/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(APPV717F)109Ili/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(APPV717F)109Ili/0,Tg(GFAP-APOE_i2)14Hol/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(Prnp-Abca1)EHol/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae,Tg(Thy1-APPSwDutIowa)BWevn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae,Ldlrtm1(LDLR)Mae/Ldlr+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae,Tg(Thy1-APPSwDutIowa)BWevn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae,Ldlrtm1(LDLR)Mae/Ldlr+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm2(APOE_i3)Yhg,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Apoetm1Unc/Apoetm3(APOE_i4)Yhg,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2

 MP:0003348 hypopituitarism "reduction or cessation of secretion of one or more hormones from the anterior pituitary gland; this may result from ablation, tumors, infarction, or other trauma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

 MP:0003394 increased cardiac output "greater than normal blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(Eno2-APOE_i3)1Rabr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: B6.129-Apoetm1Unc Cdkn1atm1Tyj

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cdh18Tg(GFAP-APOE_i4)1Hol/0
Genetic Background: B6.Cg-Apoetm1Unc Cdh18Tg(GFAP-APOE_i4)1Hol/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(GFAP-APOE_i4)22Hol/0
Genetic Background: B6.Cg-Apoetm1Unc Tg(GFAP-APOE_i4)22Hol

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pon1tm1Lus/Pon1tm1Lus
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Serpind1tm1Moto/Serpind1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nfe2l2tm1Mym/Nfe2l2tm1Mym
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003692 xanthoma "a deposit of cholesterol rich material in a tissue, most often in the skin but also seen in tendons and in the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Lmh/Apoetm1Lmh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: KOR-Apoeshl

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: C3.KOR-Apoeshl

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: C.KOR-Apoeshl

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: B6.KOR-Apoeshl

Allelic Composition: Apoeshl/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * KOR

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: involves: C3H/He * KOR

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: involves: BALB/c * KOR

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: involves: C57BL/6 * KOR

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

Allelic Composition: Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Bres/Apoetm1Bres
Genetic Background: B6.129P2-Apoetm1Bres

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: MRL.Cg-Apoetm1Unc Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0003726 decreased autoantibody level "reduced level of antibodies to self-antigens present in the sera" [acv:Alicia Valenzuela, Genetic Resources Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0003733 abnormal inner nuclear layer morphology "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0003795 abnormal bone structure 
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Cx3cr1tm1Ifc/Cx3cr1tm1Ifc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cx3cl1tm1Sgs/Cx3cl1tm1Sgs
Genetic Background: B6.129-Apoetm1Unc Cx3cl1tm1Sgs

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Glg1Gt(RST092)Byg/Glg1+
Genetic Background: B6J.129P2-Apoetm1Unc Glg1Gt(RST092)Byg

 MP:0003814 vascular smooth muscle cell hypoplasia "decreased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Klf15tm2Jain/Klf15tm2Jain,Tg(Tagln-cre)1Jjl/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Sprr3tm1.1Ppy/Sprr3tm1.1Ppy
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J * SJL

 MP:0003858 enhanced coordination "improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(Eno2-APOE_i3)1Rabr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex
Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Glg1Gt(RST092)Byg/Glg1+
Genetic Background: B6J.129P2-Apoetm1Unc Glg1Gt(RST092)Byg

Allelic Composition: Apoetm1.1Mae/Apoetm1.1Mae,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Apoetm1.1Mae Tg(Fabp4-cre)1Rev

 MP:0003897 abnormal ST interval "anomaly in the time between the end of S-wave and the beginning of T-wave" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc Apoetm1Unc

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Kuz/Ccr5tm1Kuz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Blck/Ccr5tm1Blck
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003947 abnormal cholesterol level "anomaly in the concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0003949 abnormal circulating lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lpltm1Sem/Lpltm1Sem
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae,Ldlrtm1(LDLR)Mae/Ldlr+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae,Ldlrtm1(LDLR)Mae/Ldlr+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm4Mae/Apoetm4Mae
Genetic Background: 129S6/SvEvTac-Apoetm4Mae

Allelic Composition: Apoetm1Khw/Apoetm1Khw,Tg(Mx1-cre)29-4Her/0
Genetic Background: B6.Cg-Apoetm1Khw Tg(Mx1-cre)29-4Her

 MP:0003950 abnormal plasma membrane morphology "anomalous structure of the semipermeable membrane that encloses the cytoplasm of a cell" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd

 MP:0003975 increased circulating VLDL triglyceride level "higher than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(APOC1)1Bres/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

Allelic Composition: Apobec1tm1Rub/Apobec1tm1Rub,Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0003976 decreased circulating VLDL triglyceride level "lower than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003980 increased circulating phospholipid level "greater concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lipgtm1Tq/Lipgtm1Tq
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ptgdrtm1Dgen/Ptgdrtm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1.1Mae/Apoetm1.1Mae,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Apoetm1.1Mae Tg(Fabp4-cre)1Rev

 MP:0003983 decreased cholesterol level "less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apobec1tm1Ishi/Apobec1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex
Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc

Allelic Composition: Apoetm1.1Mae/Apoetm1.1Mae,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Apoetm1.1Mae Tg(Fabp4-cre)1Rev

 MP:0003991 arteriosclerosis "thickening, hardening and/or loss of elasticity of the walls of arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0004044 aortic dissection "a pathologic process, characterized by splitting of the media layer of the aorta, which leads to formation of a dissecting aneurysm" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129-Nos3tm1Plh Apoetm1Unc

 MP:0004111 abnormal coronary artery morphology "anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il1rntm1Dih/Il1rntm1Dih
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0004113 abnormal aortic arch morphology "structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004148 increased cortical bone thickness "thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0004153 increased renal tubule apoptosis "increase in the number of renal tubule cells undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0004254 cerebral amyloid angiopathy "a pathological condition where there is a deposition of amyloid in the walls of the small cerebral vessels which supply the brain; this results in an increased risk of infarcts and/or intracerebral hemorrhage, possibly resulting in dementia" [acv:Alicia Valenzuela_Genetic Resources Curator]
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Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004308 abnormal basilar membrane "any structural abnormality in the membrane extending from the bony spiral membrane to the basilar crest of the cochlea; it forms the greater part of the floor of the cochlear duct separating the latter from the scala tympani, and it supports the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0004629 abnormal spiral modiolar artery morphology "any structural anomaly of the artery which parallels the spiral ganglion in the root of the spiral lamina of the modiolus, serving the ganglion and the cochlear duct and its contents" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0004630 spiral modiolar artery stenosis "abnormal narrowing of the artery which parallels the spiral ganglion in the root of the spiral lamina of the modiolus and serves the ganglion and the cochlear duct and its contents" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: MRL.Cg-Apoetm1Unc Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0004769 abnormal synaptic vesicle morphology "any structural anomaly of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

 MP:0004777 abnormal phospholipid level "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0004778 increased foam cell number "greater than normal number of a type of macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions" [CL:0000517]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cx3cl1tm1Sgs/Cx3cl1tm1Sgs
Genetic Background: B6.129-Apoetm1Unc Cx3cl1tm1Sgs

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: MRL.Cg-Apoetm1Unc Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: MRL.Cg-Apoetm1Unc Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129-Nos3tm1Plh Apoetm1Unc

 MP:0004879 decreased systemic vascular resistance "reduction in the normal force opposing blood flow in the peripheral blood vessels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lpltm1Sem/Lpltm1Sem
Genetic Background: involves: 129P2/OlaHsd

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ay/a,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

Allelic Composition: Ay/a,Apoetm1Unc/Apoetm1Unc,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

 MP:0004894 uterus atrophy "wasting of the uterus due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: B6.129P2-Apoetm1Bres Esr1tm1Ksk

 MP:0004904 increased uterus weight "increase in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Rag2tm1Fwa/Rag2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Notch2tm1Grid/Notch2tm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kmt2atm1.1Mlc/Kmt2atm1.1Mlc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Blck/Ccr5tm1Blck
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng,Tg(Myod1-BCL2)1Jbm/?
Genetic Background: B6.Cg-Lama2tm1Eeng Tg(Myod1-BCL2)1Jbm

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
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Allelic Composition: F2rtm1.1Cgh/F2rtm1.1Cgh,F2rl1tm2Cgh/F2rl1tm2Cgh,Tg(Tek-F2r)1Cgh/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129-Nos3tm1Plh Apoetm1Unc

 MP:0005145 increased circulating VLDL cholesterol level "greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Lmh/Apoetm1Lmh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(APOC1)1Bres/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hdl5C57BL/6J/Hdl5C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hdlq86C3H/HeJ/Hdlq86C3H/HeJ
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hdlq86C3H/HeJ/?
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nhdlq11C3H/HeJ/Nhdlq11C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nhdlq11C3H/HeJ/Nhdlq11C3H/HeJ
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nhdlq12C3H/HeJ/Nhdlq12C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nhdlq12C57BL/6J/Nhdlq12C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pnhdlc1C57BL/6J/Pnhdlc1C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pnhdlc6C3H/HeJ/?
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lipgtm1Tq/Lipgtm1Tq
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Npc1m1N/Npc1m1N
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Apoetm1Khw/Apoetm1Khw
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Khw/Apoetm1Khw,Tg(Mx1-cre)29-4Her/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * SJL

Allelic Composition: Apoetm4Mae/Apoetm4Mae
Genetic Background: 129S6/SvEvTac-Apoetm4Mae

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Apoetm1Khw/Apoetm1Khw,Tg(Mx1-cre)29-4Her/0
Genetic Background: B6.Cg-Apoetm1Khw Tg(Mx1-cre)29-4Her

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apobtm1Sgy/Apobtm1Sgy,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005146 decreased circulating VLDL cholesterol level "less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1atm2(HBx)Xya/Cdkn1atm2(HBx)Xya
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)

Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her,Lrp1tm2Her/Lrp1tm2Her,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Rraf/Apoetm1Rraf,Tg(Mx1-cre)29-4Her/0
Genetic Background: B6.Cg-Apoetm1Rraf Tg(Mx1-cre)29-4Her

 MP:0005167 abnormal blood-brain barrier "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Apoetm1Lmh/Apoetm1Lmh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Msr1tm1Csk/Msr1tm1Csk
Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR)

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(APOC1)1Bres/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pla2g15tm1Ytan/Pla2g15tm1Ytan
Genetic Background: involves: 129S/SvEv * B6.129P2-Apoetm1Unc/J

Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss

Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoc1tm2Lmh/Apoc1tm2Lmh,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: KOR-Apoeshl

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: C3.KOR-Apoeshl

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: C.KOR-Apoeshl

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: B6.KOR-Apoeshl

Allelic Composition: Apoeshl/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * KOR

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: involves: C3H/He * KOR

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: involves: BALB/c * KOR

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: involves: C57BL/6 * KOR

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lipgtm1Tq/Lipgtm1Tq
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lgals3tm1Poi/Lgals3tm1Poi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her,Lrp1tm2Her/Lrp1tm2Her,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: MRL.Cg-Apoetm1Unc Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

Allelic Composition: ApoeTg(rtTA)1Gaga/ApoeTg(rtTA)1Gaga
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: ApoeTg(rtTA)1Gaga/ApoeTg(rtTA)1Gaga,Igs7tm1(tetO-Apoe)Gaga/0
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(CMV-Serpine1)1Dgi/0
Genetic Background: B6.Cg-Apoetm1Unc Tg(CMV-Serpine1)1Dgi

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129-Serpine1tm1Mlg Apoetm1Unc

Allelic Composition: Apoetm1Khw/Apoetm1Khw
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Khw/Apoetm1Khw,Tg(Mx1-cre)29-4Her/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(Cyp21a1-Apoe)619Fet/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Csf1op/Csf1op
Genetic Background: involves: 129P2/OlaHsd * C3HeB/Fe * C57BL/6

Allelic Composition: Apobec1tm1Chan/Apobec1tm1Chan,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lpltm1Sem/Lpltm1Sem
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae,Ldlrtm1(LDLR)Mae/Ldlr+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Spp1tm1Rit/Spp1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * SJL

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Apoetm4Mae/Apoetm4Mae
Genetic Background: 129S6/SvEvTac-Apoetm4Mae

Allelic Composition: Ay/a,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

Allelic Composition: Ay/a,Apoetm1Unc/Apoetm1Unc,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ptgdrtm1Dgen/Ptgdrtm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Rraf/Apoetm1Rraf,Tg(Mx1-cre)29-4Her/0
Genetic Background: B6.Cg-Apoetm1Rraf Tg(Mx1-cre)29-4Her

Allelic Composition: Apoetm1Khw/Apoetm1Khw,Tg(Mx1-cre)29-4Her/0
Genetic Background: B6.Cg-Apoetm1Khw Tg(Mx1-cre)29-4Her

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Klf15tm1Jain/Klf15tm1Jain
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apobtm1Sgy/Apobtm1Sgy,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dlx5/Dlx6tm1Levi/Dlx5/Dlx6tm1Levi
Genetic Background: Not Specified

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Apoa2tm1Bres/Apoa2tm1Bres,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Apoa2tm1Bres/Apoa2+,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Apoetm1(APOE)Kyan/Apoetm1(APOE)Kyan
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apoetm2(APOE)Sfu/Apoetm2(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat2tm1Far/Soat2tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il1rntm1Dih/Il1rntm1Dih
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Rag2tm1Fwa/Rag2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her,Lrp1tm2Her/Lrp1tm2Her,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Apoetm1Unc

Allelic Composition: Angptl3tm1Lex/Angptl3tm1Lex,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

Allelic Composition: Apobec1tm1Rub/Apobec1tm1Rub,Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apobec1tm1Chan/Apobec1tm1Chan,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pik3cgtm1Dwu/Pik3cgtm1Dwu
Genetic Background: B6.Cg-Apoetm1Unc Pik3cgtm1Dwu

Allelic Composition: Apoetm1.1Mae/Apoetm1.1Mae,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Apoetm1.1Mae Tg(Fabp4-cre)1Rev

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Smarcd1tm1.1Jddl/Smarcd1tm1.1Jddl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005239 abnormal Bruch membrane morphology "anomalous structure of the transparent, nearly structureless inner layer of the choroid in contact with the pigmented layer of the retina" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ay/a,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
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Allelic Composition: Cdkn1atm2(HBx)Xya/Cdkn1atm2(HBx)Xya
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)

Allelic Composition: Apoc1tm2Lmh/Apoc1tm2Lmh,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lcattm1Hgc/Lcattm1Hgc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nceh1tm1Ishi/Nceh1tm1Ishi
Genetic Background: B6.129-Nceh1tm1Ishi Apoetm1Unc

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Apoetm1Unc

Allelic Composition: Apoetm1.1Mae/Apoetm1.1Mae,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Apoetm1.1Mae Tg(Fabp4-cre)1Rev

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cbstm1Unc/Cbstm1Unc,Tg(Mt1-CBS)25Waku/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hdlq86C3H/HeJ/Hdlq86C3H/HeJ
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hdlq86C3H/HeJ/?
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Trigq4C3H/HeJ/Trigq4C3H/HeJ
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Trigq4C3H/HeJ/Trigq4C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nhdlq11C3H/HeJ/Nhdlq11C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nhdlq11C3H/HeJ/Nhdlq11C3H/HeJ
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Trigq3C3H/HeJ/Trigq3C3H/HeJ
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Trigq3C3H/HeJ/?
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1.1Mae/Apoetm1.1Mae,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Apoetm1.1Mae Tg(Fabp4-cre)1Rev

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ikbkgtm1Mka/Ikbkg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ay/a,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0005335 abnormal gonadal fat pad "malformed or aberrant size of the encapsulated adipose tissue associated with the ovaries or testes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]
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Allelic Composition: Gnaqtm2.1Soff/Gnaqtm2.1Soff
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Gofm2C57BL/6J/?
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Gofm2C3H/HeJ/?
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Gofm3C57BL/6J/?
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Gofm4C3H/HeJ/?
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Msr1tm1Csk/Msr1tm1Csk
Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR)

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(APOC1)1Bres/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pon1tm1Lus/Pon1tm1Lus
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pla2g15tm1Ytan/Pla2g15tm1Ytan
Genetic Background: involves: 129S/SvEv * B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ttpatm1Far/Ttpatm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ttpatm1Far/Ttpa+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Plgtm1Jld/Plgtm1Jld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss

Allelic Composition: Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NIH Black Swiss

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Mapk8tm1Flv/Mapk8tm1Flv
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Serpind1tm1Moto/Serpind1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: involves: C3H/He * KOR

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: involves: BALB/c * KOR

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: involves: C57BL/6 * KOR

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lipgtm1Tq/Lipgtm1Tq
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hptm1Alev/Hptm1Alev
Genetic Background: involves: 129

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(CMV-Serpine1)1Dgi/0
Genetic Background: B6.Cg-Apoetm1Unc Tg(CMV-Serpine1)1Dgi

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129-Serpine1tm1Mlg Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ath30C57BL/6J/Ath30C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ath31C57BL/6J/Ath31C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ath32C57BL/6J/Ath32C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ath33C3H/HeJ/Ath33C3H/HeJ
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Athsq3C3H/HeJ/Athsq3C3H/HeJ
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tnfsf4Ath1-C57BL/6J/Tnfsf4Ath1-C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ath29C57BL/6J/Ath29C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pecam1Gt(OST16303)Lex/Pecam1Gt(OST16303)Lex
Genetic Background: B6.129-Apoetm1Unc Pecam1Gt(OST16303)Lex

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Bcl2tm1Irt/Bcl2tm1Irt,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tnfrsf11btm1Eac/Tnfrsf11btm1Eac
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pik3cgtm1Dwu/Pik3cgtm1Dwu
Genetic Background: B6.Cg-Apoetm1Unc Pik3cgtm1Dwu

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Spp1tm1Blh/Spp1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6J

Allelic Composition: Apoetm1Bres/Apoetm1Bres
Genetic Background: B6.129P2-Apoetm1Bres

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: B6.129P2-Apoetm1Bres Esr1tm1Ksk

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her,Lrp1tm2Her/Lrp1tm2Her,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Ay/a,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Kuz/Ccr5tm1Kuz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Blck/Ccr5tm1Blck
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr1tm1Gao/Ccr1tm1Gao
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Athsq3C57BL/6J/Athsq3C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Glg1Gt(RST092)Byg/Glg1+
Genetic Background: B6J.129P2-Apoetm1Unc Glg1Gt(RST092)Byg

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005339 increased susceptibility to atherosclerosis "more likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(MSR1-Plau)1Ddi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: KOR-Apoeshl

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: C3.KOR-Apoeshl

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: C.KOR-Apoeshl

Allelic Composition: Apoeshl/Apoeshl
Genetic Background: B6.KOR-Apoeshl

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ath29C57BL/6J/?
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cath1C57BL/6J/Cath1C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cath1C3H/HeJ/Cath1C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc Apoetm1Unc

Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her,Lrp1tm2Her/Lrp1tm2Her,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: MRL.Cg-Apoetm1Unc Faslpr

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

Allelic Composition: ApoeTg(rtTA)1Gaga/ApoeTg(rtTA)1Gaga
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: ApoeTg(rtTA)1Gaga/ApoeTg(rtTA)1Gaga,Igs7tm1(tetO-Apoe)Gaga/0
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nceh1tm1Ishi/Nceh1tm1Ishi
Genetic Background: B6.129-Nceh1tm1Ishi Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129-Nos3tm1Plh Apoetm1Unc

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Esr1tm1Ksk/Esr1tm1Ksk
Genetic Background: B6.129P2-Apoetm1Bres Esr1tm1Ksk

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Gja5tm1Mchn/Gja5tm1Mchn,Tg(TIE2-lacZ)182Sato/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her,Lrp1tm2Her/Lrp1tm2Her,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Crptm1Hjf/Crptm1Hjf
Genetic Background: B6.Cg-Crptm1Hjf Apoetm1Unc

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Apoetm1Khw/Apoetm1Khw,Tg(Mx1-cre)29-4Her/0
Genetic Background: B6.Cg-Apoetm1Khw Tg(Mx1-cre)29-4Her

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Klf15tm2Jain/Klf15tm2Jain,Tg(Tagln-cre)1Jjl/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Klf15tm1Jain/Klf15tm1Jain
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Sprr3tm1.1Ppy/Sprr3tm1.1Ppy
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J * SJL

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cbstm1Unc/Cbstm1Unc,Tg(Mt1-CBS)25Waku/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

Allelic Composition: Apobtm1Sgy/Apobtm1Sgy,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005340 altered susceptibility to atherosclerosis "a change in the likelihood that an organism will develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Egr1tm1Jmi/Egr1tm1Jmi
Genetic Background: involves: 129 * C57BL/6

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Cx3cr1tm1Ifc/Cx3cr1tm1Ifc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)2Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Fn1tm1Bwg/Fn1tm1Bwg
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cx3cl1tm1Sgs/Cx3cl1tm1Sgs
Genetic Background: B6.129-Apoetm1Unc Cx3cl1tm1Sgs

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: B6.129-Apoetm1Unc Cx3cr1tm1Zm

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cx3cr1tm1Zm/Cx3cr1+
Genetic Background: B6.129-Apoetm1Unc Cx3cr1tm1Zm

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat2tm1Far/Soat2tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lipgtm1Tq/Lipgtm1Tq
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lgals3tm1Poi/Lgals3tm1Poi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(CAG-IL1RN)1Cga/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/1 * FVB

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(CAG-IL1RN)2Cga/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/1 * FVB

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Ltb4r1tm1Adl/Ltb4r1tm1Adl
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(Cyp21a1-Apoe)614Fet/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(Cyp21a1-Apoe)619Fet/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Csf1op/Csf1op
Genetic Background: involves: 129P2/OlaHsd * C3HeB/Fe * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Spp1tm1Rit/Spp1+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * SJL

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nfe2l2tm1Mym/Nfe2l2tm1Mym
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: B6.129-Apoetm1Unc Cdkn1atm1Tyj

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr2tm1Ifc/Ccr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr2tm1Ifc/Ccr2tm1Ifc,Cx3cl1tm1Lira/Cx3cl1tm1Lira
Genetic Background: B6.Cg-Apoetm1Unc Cx3cl1tm1Lira Ccr2tm1Ifc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: B6.Cg-Apoetm1Unc Ccr2tm1Ifc

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cxcl10tm1Adl/Cxcl10tm1Adl
Genetic Background: B6.129-Cxcl10tm1Adl Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129-Il1r1tm1Imx Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd44tm1Mak/Cd44tm1Mak
Genetic Background: B6.129P2-Cd44tm1Mak Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd44tm1Mak/Cd44+
Genetic Background: B6.129P2-Cd44tm1Mak Apoetm1Unc

Allelic Composition: Apoetm4Mae/Apoetm4Mae
Genetic Background: 129S6/SvEvTac-Apoetm4Mae

Allelic Composition: Apoetm1Bres/Apoetm1Bres,C6Q0/C6Q0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Dp(17Nfkbil1-Olfr91)1Cogr/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Apoetm1Rraf/Apoetm1Rraf,Tg(Mx1-cre)29-4Her/0
Genetic Background: B6.Cg-Apoetm1Rraf Tg(Mx1-cre)29-4Her

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Arhgef26tm1.1Kbur/Arhgef26tm1.1Kbur
Genetic Background: B6.Cg-Arhgef26tm1.1Kbur Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex
Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ddit3tm1.1Irt/Ddit3tm1.1Irt,Taglntm2(cre)Yec/Tagln+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Smarcd1tm1.1Jddl/Smarcd1tm1.1Jddl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0005365 abnormal bile salt homeostasis "anomalous regulation of the steroid salts derived from cholesterol in the liver and which play an important role in the digestion and absorption of fats" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86154]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Smarcd1tm1.1Jddl/Smarcd1tm1.1Jddl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0005412 vascular stenosis "narrowing or constriction of a blood vessel" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(CAG-IL1RN)1Cga/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/1 * FVB

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(CAG-IL1RN)2Cga/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/1 * FVB

Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her,Lrp1tm2Her/Lrp1tm2Her,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(Cyp21a1-Apoe)614Fet/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(Cyp21a1-Apoe)619Fet/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lcattm1Hgc/Lcattm1Hgc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Klf15tm2Jain/Klf15tm2Jain,Tg(Tagln-cre)1Jjl/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Apoetm1.1Mae/Apoetm1.1Mae,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Apoetm1.1Mae Tg(Fabp4-cre)1Rev

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0005489 vascular smooth muscle cell hyperplasia "increased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:48446]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0005548 retinal pigment epithelium atrophy "wasting or decreased size of the epithelial layer of the retina composed of cells containing pigment granules " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc Apoetm1Unc

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nfe2l2tm1Mym/Nfe2l2tm1Mym
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Apoetm1Unc

Allelic Composition: Apoetm1.1Mae/Apoetm1.1Mae,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Apoetm1.1Mae Tg(Fabp4-cre)1Rev

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Thbdtm1.1(THBD)Sltz/Thbdtm1.1(THBD)Sltz
Genetic Background: B6.129(FVB)-Thbdtm1.1(THBD)Sltz Apoetm1Unc

 MP:0005590 increased vasodilation "greater than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129-Il1r1tm1Imx Apoetm1Unc

 MP:0005591 decreased vasodilation "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Kuz/Ccr5tm1Kuz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: B6.129-Apoetm1Unc Cdkn1atm1Tyj

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Sprr3tm1.1Ppy/Sprr3tm1.1Ppy
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J * SJL

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Ay/a,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

Allelic Composition: Ay/a,Apoetm1Unc/Apoetm1Unc,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslgld/Faslgld
Genetic Background: B6.Cg-Faslgld Apoetm1Unc

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(Eno2-APP*751)10Cord/0,Cdh18Tg(GFAP-APOE_i4)1Hol/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(Eno2-APP*751)10Cord/0,Tg(GFAP-APOE_i3)37Hol/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0006060 increased cerebral infarction size "increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(Eno2-APP*751)10Cord/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006076 abnormal circulating homocysteine level "aberrant concentration in the blood of this amino acid" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0006133 arterial calcification "pathologic deposition of calcium salts in the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Spp1tm1Rit/Spp1tm1Rit
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0006134 arterial occlusion "blockage of blood flow through one or more arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(MSR1-Plau)1Ddi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc Apoetm1Unc

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0006278 aortic aneurysm "protruding sac formed by dilation of the aorta" [J:110586, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129-Nos3tm1Plh Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cxcl10tm1Adl/Cxcl10tm1Adl
Genetic Background: B6.129-Cxcl10tm1Adl Apoetm1Unc

 MP:0006319 abnormal epididymal fat pad "any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0008009 delayed cellular replicative senescence "slower progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: B6.129-Apoetm1Unc Cdkn1atm1Tyj

 MP:0008033 impaired lipolysis "reduction in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(APOC1)1Bres/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0008073 abnormal CD4-positive T cell number "anomaly in the number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cxcl10tm1Adl/Cxcl10tm1Adl
Genetic Background: B6.129-Cxcl10tm1Adl Apoetm1Unc

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0008090 increased T-helper 2 cell number "greater number of the subset of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(Eno2-APOE_i4)1Rabr/0
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0008243 abnormal foam cell morphology "any structural anomaly of a type of macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions" [CL:0000517]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd36tm1Mfe/Cd36tm1Mfe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex
Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc

 MP:0008248 abnormal mononuclear phagocyte morphology "any structural anomaly of a vertebrate phagocyte with a single nucleus" [CL:0000113]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Kuz/Ccr5tm1Kuz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Blck/Ccr5tm1Blck
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008288 abnormal adrenal cortex morphology "any structural anomaly of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

 MP:0008289 abnormal adrenal medulla morphology "any structural anomaly of the inner portion of the adrenal gland that consists mainly of chromaffin cells which produce, store and secrete neurotransmitters such as epinephrine and norepinephrine" [MESH:A06.407.071.265, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

 MP:0008389 hypochromic macrocytic anemia "hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, where the erythrocyte corpuscular volume is larger than normal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008406 increased cellular sensitivity to hydrogen peroxide "greater incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Sprr3tm1.1Ppy/Sprr3tm1.1Ppy
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J * SJL

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(GFAP-APOE_i4)#Hol/0
Genetic Background: B6.Cg-Apoetm1Unc Tg(GFAP-APOE_i4)#Hol

Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Genetic Background: B6.129P2-Apoetm3(APOE*4)Mae

 MP:0008511 thin retinal inner nuclear layer "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008544 impaired olfaction "reduced ability to detect odors" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cbstm1Unc/Cbstm1Unc,Tg(Mt1-CBS)25Waku/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex
Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr1tm1Gao/Ccr1tm1Gao
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Kuz/Ccr5tm1Kuz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Blck/Ccr5tm1Blck
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129-Il1r1tm1Imx Apoetm1Unc

 MP:0008617 increased circulating interleukin-12 level "increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Kuz/Ccr5tm1Kuz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Blck/Ccr5tm1Blck
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008817 hematoma "an abnormal localized accumulation of clotted or partially clotted blood in an organ or a soft tissue space as a result of localized hemorrhage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cxcl10tm1Adl/Cxcl10tm1Adl
Genetic Background: B6.129-Cxcl10tm1Adl Apoetm1Unc

 MP:0008852 retinal neovascularization "formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina" [MESH:C11.768.725]
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Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008916 abnormal astrocyte physiology "any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cdh18Tg(GFAP-APOE_i4)1Hol/0
Genetic Background: B6.Cg-Apoetm1Unc Cdh18Tg(GFAP-APOE_i4)1Hol/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(GFAP-APOE_i3)37Hol/0
Genetic Background: B6.Cg-Tg(GFAP-APOE_i3)37Hol Apoetm1Unc/J

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009122 decreased white fat cell lipid droplet size "reduction in the size of the single large lipid droplet or vacuole of white fat cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1.1Mae/Apoetm1.1Mae,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Apoetm1.1Mae Tg(Fabp4-cre)1Rev

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1.1Mae/Apoetm1.1Mae,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Apoetm1.1Mae Tg(Fabp4-cre)1Rev

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex
Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

Allelic Composition: Apoetm1.1Mae/Apoetm1.1Mae,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Apoetm1.1Mae Tg(Fabp4-cre)1Rev

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1.1Mae/Apoetm1.1Mae,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Apoetm1.1Mae Tg(Fabp4-cre)1Rev

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(MSR1-Plau)1Ddi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129-Apoetm1Unc Ifngtm1Ts

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cxcl10tm1Adl/Cxcl10tm1Adl
Genetic Background: B6.129-Cxcl10tm1Adl Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Klf15tm1Jain/Klf15tm1Jain
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: B6.129-Apoetm1Unc Cdkn1atm1Tyj

 MP:0009814 increased prostaglandin level "increase in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009862 abnormal aorta elastic tissue morphology "any structural anomaly of the dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il1rntm1Dih/Il1rntm1Dih
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0009864 abnormal aorta endothelium morphology "any strucutral anomaly of the thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pecam1Gt(OST16303)Lex/Pecam1Gt(OST16303)Lex
Genetic Background: B6.129-Apoetm1Unc Pecam1Gt(OST16303)Lex

 MP:0009866 abnormal aorta wall morphology "any structural anomaly of the part of the aorta that encloses the luminal space" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0009868 abnormal descending thoracic aorta morphology "any structural anomaly of the part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest" [http://www.medterms.com "MedicineNet.com"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ncf1tm1Shl/Ncf1tm1Shl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0009873 abnormal aorta tunica media morphology "any structural anomaly of the middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0009932 skin fibrosis "invasion of fibrous connective tissue into the skin, often resulting from inflammation or injury" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0010026 decreased liver cholesterol level "less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1.1Mae/Apoetm1.1Mae,Tg(Fabp4-cre)1Rev/0
Genetic Background: B6.Cg-Apoetm1.1Mae Tg(Fabp4-cre)1Rev

 MP:0010161 decreased brain cholesterol level "less than normal amount in the brain of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0010210 abnormal circulating cytokine level "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0010331 abnormal apolipoprotein level "anomaly in the amount of the a protein that is frequently a component of a lipoprotein complex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Apoetm1Rraf/Apoetm1Rraf,Tg(Mx1-cre)29-4Her/0
Genetic Background: B6.Cg-Apoetm1Rraf Tg(Mx1-cre)29-4Her

Allelic Composition: Apoetm1Khw/Apoetm1Khw,Tg(Mx1-cre)29-4Her/0
Genetic Background: B6.Cg-Apoetm1Khw Tg(Mx1-cre)29-4Her

 MP:0010451 kidney microaneurysm "focal dilation of arteriocapillary junctions in the kidney" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0010483 aortic sinus aneurysm "a protruding sac formed by the dilation of the wall of the aortic sinus resulting from a weakening of the vessel wall" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc Apoetm1Unc

 MP:0010574 aorta dilation "the luminal space of the aorta is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129-Apoetm1Unc Ifngtm1Ts

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cxcl10tm1Adl/Cxcl10tm1Adl
Genetic Background: B6.129-Cxcl10tm1Adl Apoetm1Unc

 MP:0010658 thoracic aorta aneurysm "a protruding sac formed by the dilation of the wall of the part of the aorta that extends from the origin at the heart to the diaphragm, resulting from a weakening of the vessel wall" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cxcl10tm1Adl/Cxcl10tm1Adl
Genetic Background: B6.129-Cxcl10tm1Adl Apoetm1Unc

 MP:0010659 abdominal aorta aneurysm "a protruding sac formed by the dilation of the wall of the part of the descending aorta that begins at the diaphragm and continues to the point of the common iliac arteries, resulting from a weakening of the vessel wall" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ifngtm1Ts/Ifngtm1Ts
Genetic Background: B6.129-Apoetm1Unc Ifngtm1Ts

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cxcl10tm1Adl/Cxcl10tm1Adl
Genetic Background: B6.129-Cxcl10tm1Adl Apoetm1Unc

 MP:0010663 abnormal brachiocephalic trunk morphology "any structural anomaly of the short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tnfrsf11btm1Eac/Tnfrsf11btm1Eac
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129-Nos3tm1Plh Apoetm1Unc

 MP:0010760 abnormal macrophage chemotaxis "anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il1rntm1Dih/Il1rntm1Dih
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hptm1Alev/Hptm1Alev
Genetic Background: involves: 129

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cxcl10tm1Adl/Cxcl10tm1Adl
Genetic Background: B6.129-Cxcl10tm1Adl Apoetm1Unc

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0010895 increased lung compliance "increased ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0010922 alveolitis "inflammation of the small sac-like dilations of the distal airspace of the lung; acute pulmonary alveolitis involves exudate into the pulmonary alveoli and impaired gas exchange" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Gja5tm1Mchn/Gja5tm1Mchn,Tg(TIE2-lacZ)182Sato/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0010933 decreased trabecular bone connectivity density "reduction in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures" [ISBN:0120986523 "Principles of bone biology, Volume 1, Bilezikian, JP et al, eds"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0010935 increased airway resistance "greater opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow" [MGI:csmith]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0010950 abnormal lung hysteresivity "anomaly in the lung tissue property defined as the ratio of dissipated energy to stored energy over a respiratory cycle; it can be measured as the area enclosed by a pressure-volume loop of the lung, and is dependent on composition and microstructure of the tissue components such as the elastic connective tissue" [PMID:2606848]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0011080 increased macrophage apoptosis "greater incidence of cell death in macrophages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Bcl2tm1Irt/Bcl2tm1Irt,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0011231 abnormal vitamin E level "any anomaly in the concentration of vitamin E, tocopherol, including a series of eight structurally similar compounds; alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant" [GO:0010189]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ttpatm1Far/Ttpa+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0011294 renal glomerulus hypertrophy "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0011309 abnormal kidney arterial blood vessel morphology "any structural anomaly of the network of tubes that supply blood to the renal tissues" [MGI:csmith]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0011339 abnormal glomerular mesangium morphology "any structural anomaly of the inner layer of the glomerulus within the basement membrane surrounding the glomerular capillaries that contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Ay/a,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0011430 mesangiolysis "an injurious glomerular process that affects primarily the mesangium, starting with loosening and detachment of its matrix and progressing to dissolution/attenuation with degeneration of mesangial cells; mesangial cells may show only edema and vacuolization, or may undergo severe degeneration and necrosis" [MGI:anna]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0011477 abnormal urine nucleoside level "any change in the urinary level of glycosylamines consisting of a nucleobase bound to a ribose or deoxyribose sugar via a beta-glycosidic linkage, including cytidine, uridine, adenosine, guanosine, thymidine and inosine and deoxynucleosides" [MGI:csmith]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Serpind1tm1Moto/Serpind1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0011508 glomerular capillary thrombosis "formation or presence of a thrombus within the renal glomerular capillaries" [MGI:anna]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0011509 dilated glomerular capillary "stretched or widened aperture of the luminal space of the small branching blood vessel in the kidney glomerulus that receives blood from the kidney afferent arteriole" [MGI:anna]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0011561 renal glomerulus lipidosis "presence of lipid deposits and/or lipid-laden foam cells in the renal glomerular tufts" [MGI:anna]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0011567 increased renal glomerulus lobularity "distortion of the renal glomerular architecture usually accompanied by increased mesangial cell proliferation and following crowding of the proliferated cells towards the axis of the capillary loops and peripheral recanalization, giving the glomerular tuft a lobular or hypersegmented appearance" [MGI:anna]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

 MP:0011572 abnormal aorta bulb morphology "any structural anomaly of the portion of the left ventricular outflow tract delineated by the sinotubular ridge superiorly and the bases of the valve leaflets inferiorly; it comprises the aortic sinuses, the aortic valve leaflets, the commissures, and the interleaflet triangles" [MGI:csmith, PMID:10722531]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0011578 increased lipoprotein lipase activity "greater ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate" [GO:0004465]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(APOC1)1Bres/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0011581 increased triglyceride lipase activity "greater ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion" [GO:0004806]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(APOC1)1Bres/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0011599 increased phosphatidylcholine-sterol O-acyltransferase activity "greater ability to catalyze the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine" [GO:0004731]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat2tm1Far/Soat2tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

 MP:0011951 increased cardiac stroke volume "increase in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc/J

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
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Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0012335 increased circulating homocysteine level "greater amount in the blood of sulfur-containing alpha-amino acid found in the plasma; blood levels are regulated by folic acid, vitamin B6 and vitamin B12" [MGI:csmith]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cbstm1Unc/Cbstm1Unc,Tg(Mt1-CBS)25Waku/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0013022 increased Ly6C high monocyte number "increase in the number of monocytes that express high levels of Ly6C and low MHC class II that represent a subset of circulating inflammatory monocytes that are recruited to infected or inflamed tissues" [MGI:Annie_Speak]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cbstm1Unc/Cbstm1Unc,Tg(Mt1-CBS)25Waku/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0014169 decreased brown adipose tissue mass "decreased physical bulk or volume of brown adipose tissue" [MGI:csmith]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

 MP:0020253 increased collagen level "increased level of the main structural protein of the various connective tissues in animals" [GOC:NV, PMID:11704682]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Glg1Gt(RST092)Byg/Glg1+
Genetic Background: B6J.129P2-Apoetm1Unc Glg1Gt(RST092)Byg

 MP:0020408 altered susceptibility to induced thrombosis "any anomaly in the formation of thrombi following mechanical or chemical stimulation of thrombosis" [PMID:16614756, PMID:9262402]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lpltm1Sem/Lpltm1Sem
Genetic Background: involves: 129P2/OlaHsd

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Faslpr/Faslpr
Genetic Background: B6.Cg-Apoetm1Unc Faslpr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032081 Apoc3 / apolipoprotein C-III isoform c / P02656* / apolipoprotein C3*  / reaction / complex
 ENSMUSG00000109350 Q05020 / Gm44805 / predicted gene 44805 / APOC2* / P02655* / apolipoprotein C2*  / complex / reaction
 ENSMUSG00000032193 Ldlr / P35951 / Low-density lipoprotein receptor / P01130*  / complex / reaction
 ENSMUSG00000028613 Lrp8 / Q924X6 / Low-density lipoprotein receptor-related protein 8 / Q14114* / LDL receptor related protein 8*  / reaction
 ENSMUSG00000027070 Lrp2 / A2ARV4 / low density lipoprotein receptor-related protein 2 / P98164* / LDL receptor related protein 2*  / reaction






 

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