ENSMUSG00000032081


Mus musculus

Features
Gene ID: ENSMUSG00000032081
  
Biological name :Apoc3
  
Synonyms : Apoc3 / apolipoprotein C-III isoform c
  
Possible biological names infered from orthology : apolipoprotein C3 / P02656
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.2
Gene start: 46232933
Gene end: 46235636
  
Corresponding Affymetrix probe sets: 10593169 (MoGene1.0st)   1418278_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113058
Ensembl peptide - ENSMUSP00000115025
Ensembl peptide - ENSMUSP00000113126
Ensembl peptide - ENSMUSP00000034586
NCBI entrez gene - 11814     See in Manteia.
MGI - MGI:88055
RefSeq - NM_001289756
RefSeq - NM_023114
RefSeq - NM_001289833
RefSeq - NM_001289755
RefSeq Peptide - NP_075603
RefSeq Peptide - NP_001276684
RefSeq Peptide - NP_001276685
RefSeq Peptide - NP_001276762
swissprot - A0A0R4J1N3
swissprot - D3YXN8
swissprot - E9QP56
Ensembl - ENSMUSG00000032081
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 APOC3ENSG00000110245Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008403  Apolipoprotein CIII


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0042157 lipoprotein metabolic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0008289 lipid binding IEA


Pathways (from Reactome)
Pathway description
Chylomicron assembly
Chylomicron remodeling
HDL remodeling
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fmn1tm1Awb/Fmn1ld-TgBri137
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NIH Black Swiss * SJL

 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoc3tm1Unc/Apoc3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Wdtc1Gt(RRF015)Byg/Wdtc1+
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Apoc3tm1Unc/Apoc3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wdtc1Gt(RRF015)Byg/Wdtc1+
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoa5tm1Hgc/Apoa5+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
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Allelic Composition: Fmn1tm1Awb/Fmn1ld-TgBri137
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NIH Black Swiss * SJL

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Wdtc1Gt(RRF015)Byg/Wdtc1+
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Apoc3tm1Unc/Apoc3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

Allelic Composition: Apoc3tm1Unc/Apoc3tm1Unc
Genetic Background: B6.129-Apoc3tm1Unc/J

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoc3tm1Unc/Apoc3tm1Unc
Genetic Background: B6.129-Apoc3tm1Unc/J

 MP:0005146 decreased circulating VLDL cholesterol level "less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoc3tm1Unc/Apoc3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Wdtc1Gt(RRF015)Byg/Wdtc1+
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Apoc3tm1Unc/Apoc3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Apoc3tm1Unc/Apoc3+
Genetic Background: involves: 129

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Apoc3tm1Unc/Apoc3tm1Unc
Genetic Background: B6.129-Apoc3tm1Unc/J

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Apoc3tm1Unc/Apoc3tm1Unc
Genetic Background: B6.129-Apoc3tm1Unc/J

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Apoc3tm1Unc/Apoc3tm1Unc
Genetic Background: B6.129-Apoc3tm1Unc/J

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Apoc3tm1Unc/Apoc3tm1Unc
Genetic Background: B6.129-Apoc3tm1Unc/J

 MP:0008570 lipidosis "abnormal fat metabolism with increased accumulation of specific lipids in tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoc3tm1Unc/Apoc3tm1Unc
Genetic Background: B6.129-Apoc3tm1Unc/J

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoc3tm1Unc/Apoc3tm1Unc
Genetic Background: B6.129-Apoc3tm1Unc/J

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Apoc3tm1Unc/Apoc3tm1Unc
Genetic Background: B6.129-Apoc3tm1Unc/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002985 Apoe / P08226 / Apolipoprotein E / P02649*  / complex / reaction
 ENSMUSG00000109350 Q05020 / Gm44805 / predicted gene 44805 / APOC2* / P02655* / apolipoprotein C2*  / complex / reaction






 

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