ENSG00000110245


Homo sapiens

Features
Gene ID: ENSG00000110245
  
Biological name :APOC3
  
Synonyms : APOC3 / apolipoprotein C3 / P02656
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q23.3
Gene start: 116829706
Gene end: 116833072
  
Corresponding Affymetrix probe sets: 205820_s_at (Human Genome U133 Plus 2.0 Array)   231587_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000227667
Ensembl peptide - ENSP00000486182
Ensembl peptide - ENSP00000410614
Ensembl peptide - ENSP00000364494
NCBI entrez gene - 345     See in Manteia.
OMIM - 107720
RefSeq - NM_000040
RefSeq Peptide - NP_000031
swissprot - C9J2Q0
swissprot - B0YIW2
swissprot - A3KPE2
swissprot - P02656
Ensembl - ENSG00000110245
  
Related genetic diseases (OMIM): 614028 - Apolipoprotein C-III deficiency, 614028
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Apoc3ENSMUSG00000032081Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008403  Apolipoprotein CIII


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001523 retinoid metabolic process TAS
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006641 triglyceride metabolic process IMP
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0010897 negative regulation of triglyceride catabolic process IDA
 biological_processGO:0010903 negative regulation of very-low-density lipoprotein particle remodeling IDA
 biological_processGO:0010916 negative regulation of very-low-density lipoprotein particle clearance IDA
 biological_processGO:0010987 negative regulation of high-density lipoprotein particle clearance IMP
 biological_processGO:0010989 negative regulation of low-density lipoprotein particle clearance IMP
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0019433 triglyceride catabolic process IDA
 biological_processGO:0032489 regulation of Cdc42 protein signal transduction IDA
 biological_processGO:0033344 cholesterol efflux IDA
 biological_processGO:0033700 phospholipid efflux IDA
 biological_processGO:0034371 chylomicron remodeling TAS
 biological_processGO:0034375 high-density lipoprotein particle remodeling TAS
 biological_processGO:0034378 chylomicron assembly TAS
 biological_processGO:0034379 very-low-density lipoprotein particle assembly TAS
 biological_processGO:0034382 chylomicron remnant clearance IDA
 biological_processGO:0042157 lipoprotein metabolic process IEA
 biological_processGO:0042632 cholesterol homeostasis IMP
 biological_processGO:0043691 reverse cholesterol transport IC
 biological_processGO:0045717 negative regulation of fatty acid biosynthetic process IDA
 biological_processGO:0045833 negative regulation of lipid metabolic process IDA
 biological_processGO:0048261 negative regulation of receptor-mediated endocytosis IDA
 biological_processGO:0050995 negative regulation of lipid catabolic process IDA
 biological_processGO:0051005 negative regulation of lipoprotein lipase activity IDA
 biological_processGO:0060621 negative regulation of cholesterol import IMP
 biological_processGO:0070328 triglyceride homeostasis IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005769 early endosome TAS
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0034361 very-low-density lipoprotein particle IDA
 cellular_componentGO:0034363 intermediate-density lipoprotein particle IDA
 cellular_componentGO:0034366 spherical high-density lipoprotein particle IDA
 cellular_componentGO:0042627 chylomicron IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005543 phospholipid binding IDA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0015485 cholesterol binding IC
 molecular_functionGO:0030234 enzyme regulator activity IDA
 molecular_functionGO:0055102 lipase inhibitor activity IDA
 molecular_functionGO:0070653 high-density lipoprotein particle receptor binding IPI


Pathways (from Reactome)
Pathway description
Chylomicron assembly
Chylomicron remodeling
HDL remodeling
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0003077 Hyperlipidemia 
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 HP:0003124 Hypercholesterolemia 
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 HP:0003563 Hypobetalipoproteinemia 
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 HP:0012153 Hypotriglyceridemia "An decrease in the level of `triglycerides` (CHEBI:17855) in the `blood` (FMA:9670)." [HPO:probinson]
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 HP:0012184 Hyperalphalipoproteinemia "An elevated concentration of `high-density lipoprotein cholesterol` (CHEBI:47775) (HDL) in the `blood` (FMA:9670)." [HPO:probinson]
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000130203 APOE / P02649 / apolipoprotein E  / reaction / complex
 ENSG00000234906 APOC2 / P02655 / apolipoprotein C2  / complex / reaction






 

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