ENSMUSG00000037295


Mus musculus

Features
Gene ID: ENSMUSG00000037295
  
Biological name :Ldlrap1
  
Synonyms : Ldlrap1 / low density lipoprotein receptor adaptor protein 1 / Q8C142
  
Possible biological names infered from orthology : Q5SW96
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D3
Gene start: 134741554
Gene end: 134768024
  
Corresponding Affymetrix probe sets: 10517301 (MoGene1.0st)   1424378_at (Mouse Genome 430 2.0 Array)   1457162_at (Mouse Genome 430 2.0 Array)   1458060_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036749
NCBI entrez gene - 100017     See in Manteia.
MGI - MGI:2140175
RefSeq - NM_145554
RefSeq - XM_006538423
RefSeq Peptide - NP_663529
swissprot - Q8C142
Ensembl - ENSMUSG00000037295
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ldlrap1aENSDARG00000004311Danio rerio
 ldlrap1bENSDARG00000039750Danio rerio
 LDLRAP1ENSGALG00000001051Gallus gallus
 Q5SW96ENSG00000157978Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Numb / Q9QZS3 / NUMB, endocytic adaptor protein / P49757*ENSMUSG0000002122426
Numbl / O08919 / Numb-like protein / Q9Y6R0* / NUMB like, endocytic adaptor protein*ENSMUSG0000006316025
Gulp1 / Q8K2A1 / PTB domain-containing engulfment adapter protein 1 / Q9UBP9* / GULP, engulfment adaptor PTB domain containing 1*ENSMUSG0000005687023


Protein motifs (from Interpro)
Interpro ID Name
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0031623 receptor internalization IEA
 biological_processGO:0034383 low-density lipoprotein particle clearance IEA
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0042982 amyloid precursor protein metabolic process IEA
 biological_processGO:0043393 regulation of protein binding IEA
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis IEA
 biological_processGO:0090118 receptor-mediated endocytosis involved in cholesterol transport IEA
 biological_processGO:1903076 regulation of protein localization to plasma membrane IEA
 biological_processGO:1905602 positive regulation of receptor-mediated endocytosis involved in cholesterol transport IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005883 neurofilament IDA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0009925 basal plasma membrane IEA
 cellular_componentGO:0030121 AP-1 adaptor complex IEA
 cellular_componentGO:0030122 AP-2 adaptor complex IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0001540 amyloid-beta binding IPI
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0005102 signaling receptor binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IEA
 molecular_functionGO:0030159 receptor signaling complex scaffold activity IEA
 molecular_functionGO:0030276 clathrin binding IEA
 molecular_functionGO:0035591 signaling adaptor activity IEA
 molecular_functionGO:0035612 AP-2 adaptor complex binding IEA
 molecular_functionGO:0035615 clathrin adaptor activity IEA
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding IEA


Pathways (from Reactome)
Pathway description
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Chylomicron clearance
LDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000181 abnormal circulating LDL cholesterol level "anomalous concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

Allelic Composition: Ldlrap1Gt(OST149604)Lex/Ldlrap1Gt(OST149604)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Roratmgc26/Roratmgc26
Genetic Background: involves: D7R75M

Allelic Composition: Ldlrap1Gt(OST149604)Lex/Ldlrap1Gt(OST149604)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032193 Ldlr / P35951 / Low-density lipoprotein receptor / P01130*  / reaction / complex






 

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