ENSMUSG00000063160


Mus musculus

Features
Gene ID: ENSMUSG00000063160
  
Biological name :Numbl
  
Synonyms : Numbl / Numb-like protein / O08919
  
Possible biological names infered from orthology : NUMB like, endocytic adaptor protein / Q9Y6R0
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A3
Gene start: 27258433
Gene end: 27282144
  
Corresponding Affymetrix probe sets: 10551336 (MoGene1.0st)   1416491_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078245
NCBI entrez gene - 18223     See in Manteia.
MGI - MGI:894702
RefSeq - XM_011250452
RefSeq - NM_010950
RefSeq - XM_006539616
RefSeq - XM_006539617
RefSeq - XM_006539615
RefSeq Peptide - NP_035080
swissprot - O08919
Ensembl - ENSMUSG00000063160
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 numblENSDARG00000101949Danio rerio
 NUMBENSGALG00000009300Gallus gallus
 NUMBLENSG00000105245Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Numb / Q9QZS3 / NUMB, endocytic adaptor protein / P49757*ENSMUSG0000002122455
Q8C142 / Ldlrap1 / low density lipoprotein receptor adaptor protein 1 / Q5SW96*ENSMUSG0000003729513
Gulp1 / Q8K2A1 / PTB domain-containing engulfment adapter protein 1 / Q9UBP9* / GULP, engulfment adaptor PTB domain containing 1*ENSMUSG0000005687011


Protein motifs (from Interpro)
Interpro ID Name
 IPR006020  PTB/PI domain
 IPR010449  NUMB domain
 IPR011993  PH-like domain superfamily
 IPR016698  Numb/numb-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007405 neuroblast proliferation IGI
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0019538 protein metabolic process IEA
 biological_processGO:0021670 lateral ventricle development IMP
 biological_processGO:0021849 neuroblast division in subventricular zone IMP
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0034332 adherens junction organization IGI
 biological_processGO:0050769 positive regulation of neurogenesis IMP
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0000792 abnormal cortical marginal zone morphology 
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
Show

Allelic Composition: Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz,Tg(Nes-cre/Esr1*)4Ynj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000822 abnormal brain ventricle morphology "malformed or absent fluid filled cavities of the cerebrum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0000823 abnormal lateral ventricle morphology "malformation or absence of cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

Allelic Composition: Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz,Tg(Nes-cre/Esr1*)4Ynj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000951 sporadic seizures "occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0001361 social withdrawal "mice remain physically distant, do not sleep in piles with cagemates" [J:57125]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0001408 stereotypic behavior "repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s wrong with my mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Pde4dtm2Mct/Pde4dtm2Mct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: SfnEr/Sfn+
Genetic Background: B6CBACa Aw-J/A-SfnEr/J

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Aestm1Grid/Aestm1Grid,Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0001963 abnormal hearing "anomaly in the ability to receive auditory stimuli" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pde4dtm2Mct/Pde4dtm2Mct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aestm1Grid/Aestm1Grid,Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002196 acallosal "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0002653 abnormal ependyma morphology "malformation or absence of the cellular membrane that lines the brain ventricles and the central canal of the spinal cord" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz,Tg(Nes-cre/Esr1*)4Ynj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002948 abnormal neuronal specification "defects in the developmental patterning of neurons resulting in ectopic placement, decreased numbers or absence of mature neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:87948]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

Allelic Composition: Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz,Tg(Nes-cre/Esr1*)4Ynj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pde4dtm2Mct/Pde4dtm2Mct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
Show

Allelic Composition: Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz,Tg(Nes-cre/Esr1*)4Ynj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004279 abnormal rostral migratory stream morphology "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz,Tg(Nes-cre/Esr1*)4Ynj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pde4dtm2Mct/Pde4dtm2Mct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz,Tg(Nes-cre/Esr1*)4Ynj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Pde4dtm2Mct/Pde4dtm2Mct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0011724 ectopic cortical neuron "appearance of a cerebral cortical neuron or group of cerebral cortical neurons in a region where it is not normally found" [MGI:csmith]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0012703 decreased embryonic neuroepithelium thickness "reduced width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]
Show

Allelic Composition: Pde4dtm2Mct/Pde4dtm2Mct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020527 small thalamus "decreased size of the thalamus" [MGI:smb]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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