ENSG00000105245


Homo sapiens

Features
Gene ID: ENSG00000105245
  
Biological name :NUMBL
  
Synonyms : NUMBL / NUMB like, endocytic adaptor protein / Q9Y6R0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.2
Gene start: 40665905
Gene end: 40690972
  
Corresponding Affymetrix probe sets: 224059_s_at (Human Genome U133 Plus 2.0 Array)   242195_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000471376
Ensembl peptide - ENSP00000470794
Ensembl peptide - ENSP00000472400
Ensembl peptide - ENSP00000469310
Ensembl peptide - ENSP00000442759
Ensembl peptide - ENSP00000252891
Ensembl peptide - ENSP00000469736
NCBI entrez gene - 9253     See in Manteia.
OMIM - 604018
RefSeq - NM_001289979
RefSeq - NM_004756
RefSeq - NM_001289980
RefSeq Peptide - NP_001276909
RefSeq Peptide - NP_001276908
RefSeq Peptide - NP_004747
swissprot - Q9Y6R0
swissprot - A0A0C4DGH3
swissprot - M0QXQ4
swissprot - M0QYC2
swissprot - M0QZV7
swissprot - M0R0Q4
Ensembl - ENSG00000105245
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 numblENSDARG00000101949Danio rerio
 NUMBENSGALG00000009300Gallus gallus
 NumblENSMUSG00000063160Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NUMB / P49757 / NUMB, endocytic adaptor proteinENSG0000013396155
Q5SW96 / LDLRAP1 / low density lipoprotein receptor adaptor protein 1ENSG0000015797813
GULP1 / Q9UBP9 / GULP, engulfment adaptor PTB domain containing 1ENSG0000014436611


Protein motifs (from Interpro)
Interpro ID Name
 IPR006020  PTB/PI domain
 IPR010449  NUMB domain
 IPR011993  PH-like domain superfamily
 IPR016698  Numb/numb-like
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0007405 neuroblast proliferation IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IDA
 biological_processGO:0019538 protein metabolic process IDA
 biological_processGO:0021670 lateral ventricle development IEA
 biological_processGO:0021849 neuroblast division in subventricular zone IEA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0034332 adherens junction organization IEA
 biological_processGO:0050769 positive regulation of neurogenesis IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr