ENSMUSG00000074336


Mus musculus

Features
Gene ID: ENSMUSG00000074336
  
Biological name :Apoc4
  
Synonyms : Apoc4 / Apolipoprotein C-IV / Q61268
  
Possible biological names infered from orthology : APOC4-APOC2 / APOC4-APOC2 readthrough (NMD candidate) / apolipoprotein C4 / P55056
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 19678083
Gene end: 19681479
  
Corresponding Affymetrix probe sets: 10560614 (MoGene1.0st)   1418708_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003071
NCBI entrez gene - 11425     See in Manteia.
MGI - MGI:87878
RefSeq - NM_007385
RefSeq Peptide - NP_031411
swissprot - Q61268
Ensembl - ENSMUSG00000074336
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 APOC4ENSG00000267467Homo sapiens
 APOC4-APOC2ENSG00000224916Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR028120  Apolipoprotein C-IV


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0010890 positive regulation of sequestering of triglyceride IBA
 biological_processGO:0070328 triglyceride homeostasis ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0034361 very-low-density lipoprotein particle IDA
 cellular_componentGO:0034364 high-density lipoprotein particle ISO
 molecular_functionGO:0005319 lipid transporter activity IBA


Pathways (from Reactome)
Pathway description
VLDL assembly
VLDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Alg10btm1(KOMP)Vlcg/Alg10btm1(KOMP)Vlcg
Genetic Background: C57BL/6N-Alg10btm1(KOMP)Vlcg/Bay

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Alg10btm1(KOMP)Vlcg/Alg10btm1(KOMP)Vlcg
Genetic Background: C57BL/6N-Alg10btm1(KOMP)Vlcg/Bay

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Alg10btm1(KOMP)Vlcg/Alg10btm1(KOMP)Vlcg
Genetic Background: C57BL/6N-Alg10btm1(KOMP)Vlcg/Bay

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Alg10btm1(KOMP)Vlcg/Alg10btm1(KOMP)Vlcg
Genetic Background: C57BL/6N-Alg10btm1(KOMP)Vlcg/Bay

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Alg10btm1(KOMP)Vlcg/Alg10btm1(KOMP)Vlcg
Genetic Background: C57BL/6N-Alg10btm1(KOMP)Vlcg/Bay

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Alg10btm1(KOMP)Vlcg/Alg10btm1(KOMP)Vlcg
Genetic Background: C57BL/6N-Alg10btm1(KOMP)Vlcg/Bay

 MP:0003020 decreased circulating chloride level "reduced concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Alg10btm1(KOMP)Vlcg/Alg10btm1(KOMP)Vlcg
Genetic Background: C57BL/6N-Alg10btm1(KOMP)Vlcg/Bay

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Alg10btm1(KOMP)Vlcg/Alg10btm1(KOMP)Vlcg
Genetic Background: C57BL/6N-Alg10btm1(KOMP)Vlcg/Bay

 MP:0008039 increased NK T cell number "greater number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Alg10btm1(KOMP)Vlcg/Alg10btm1(KOMP)Vlcg
Genetic Background: C57BL/6N-Alg10btm1(KOMP)Vlcg/Bay

 MP:0013883 increased CD4-positive, CD25-positive NK T cell number "increase in the number of CD4-positive NK T cells expressing the activation marker CD25" [MGI:Abeler-Dorner]
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Allelic Composition: Alg10btm1(KOMP)Vlcg/Alg10btm1(KOMP)Vlcg
Genetic Background: C57BL/6N-Alg10btm1(KOMP)Vlcg/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000040564 Apoc1 / P34928 / Apolipoprotein C-I Truncated apolipoprotein C-I / P02654* / apolipoprotein C1*  / reaction / complex
 ENSMUSG00000042759 Apobr / Q8VBT6 / Apolipoprotein B receptor / Q0VD83*  / complex / reaction
 ENSMUSG00000001247 Lsr / Q99KG5 / Lipolysis-stimulated lipoprotein receptor / Q86X29*  / complex / reaction
 ENSMUSG00000024924 Vldlr / P98156 / very low density lipoprotein receptor / P98155*  / complex / reaction






 

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