ENSMUSG00000040564


Mus musculus

Features
Gene ID: ENSMUSG00000040564
  
Biological name :Apoc1
  
Synonyms : Apoc1 / Apolipoprotein C-I Truncated apolipoprotein C-I / P34928
  
Possible biological names infered from orthology : apolipoprotein C1 / P02654
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 19689481
Gene end: 19692660
  
Corresponding Affymetrix probe sets: 10560618 (MoGene1.0st)   1417561_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147008
Ensembl peptide - ENSMUSP00000045571
Ensembl peptide - ENSMUSP00000104091
NCBI entrez gene - 11812     See in Manteia.
MGI - MGI:88053
RefSeq - NM_001110009
RefSeq - NM_007469
RefSeq Peptide - NP_001103479
RefSeq Peptide - NP_031495
swissprot - A0A140LIY8
swissprot - P34928
Ensembl - ENSMUSG00000040564
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 APOC1ENSG00000130208Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006781  Apolipoprotein C-I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006641 triglyceride metabolic process IMP
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0008203 cholesterol metabolic process IMP
 biological_processGO:0010900 negative regulation of phosphatidylcholine catabolic process IEA
 biological_processGO:0010916 negative regulation of very-low-density lipoprotein particle clearance IEA
 biological_processGO:0032375 negative regulation of cholesterol transport IEA
 biological_processGO:0033344 cholesterol efflux IEA
 biological_processGO:0033700 phospholipid efflux IEA
 biological_processGO:0034369 plasma lipoprotein particle remodeling IEA
 biological_processGO:0034382 chylomicron remnant clearance IEA
 biological_processGO:0034447 very-low-density lipoprotein particle clearance IEA
 biological_processGO:0042157 lipoprotein metabolic process IEA
 biological_processGO:0045717 negative regulation of fatty acid biosynthetic process IEA
 biological_processGO:0045833 negative regulation of lipid metabolic process IEA
 biological_processGO:0048261 negative regulation of receptor-mediated endocytosis IEA
 biological_processGO:0050995 negative regulation of lipid catabolic process IEA
 biological_processGO:0051005 negative regulation of lipoprotein lipase activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0034361 very-low-density lipoprotein particle IEA
 cellular_componentGO:0034364 high-density lipoprotein particle IEA
 molecular_functionGO:0004859 phospholipase inhibitor activity IEA
 molecular_functionGO:0005504 fatty acid binding IEA
 molecular_functionGO:0055102 lipase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
VLDL assembly
VLDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ephb2tm1Jf/Ephb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ephb2tm1Jf/Ephb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Apoc1tm1Lmh/Apoc1tm1Lmh,Tg(CETP)5203Tall/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Ephb2tm1Jf/Ephb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ephb2tm1Jf/Ephb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Apoc1tm1Lmh/Apoc1tm1Lmh,Tg(CETP)5203Tall/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J

 MP:0004773 abnormal bile composition "any alteration in the chemical make up of the greenish-yellow fluid secreted by the liver; normally contains bile acids and salts such as sodium glycocholate and sodium taurocholate as well as cholesterol, biliverdin and bilirubin, mucus, fat, lecithin, and cells and cellular debris" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ephb2tm1Jf/Ephb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Apoc1tm1Lmh/Apoc1tm1Lmh,Tg(CETP)5203Tall/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J

 MP:0004777 abnormal phospholipid level "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoc1tm1Lmh/Apoc1tm1Lmh,Tg(CETP)5203Tall/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J

 MP:0004789 increased bile salt level "increased concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoc1tm1Lmh/Apoc1tm1Lmh,Tg(CETP)5203Tall/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ephb2tm1Jf/Ephb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Apoc1tm2Lmh/Apoc1tm2Lmh,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
Show

Allelic Composition: Apoc1tm2Lmh/Apoc1tm2Lmh,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ephb2tm1Jf/Ephb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Apoc1tm1Lmh/Apoc1tm1Lmh,Tg(CETP)5203Tall/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000074336 Apoc4 / Q61268 / Apolipoprotein C-IV / P55056* / APOC4-APOC2* / apolipoprotein C4* / APOC4-APOC2 readthrough (NMD candidate)*  / reaction / complex
 ENSMUSG00000024924 Vldlr / P98156 / very low density lipoprotein receptor / P98155*  / complex / reaction
 ENSMUSG00000042759 Apobr / Q8VBT6 / Apolipoprotein B receptor / Q0VD83*  / reaction / complex
 ENSMUSG00000001247 Lsr / Q99KG5 / Lipolysis-stimulated lipoprotein receptor / Q86X29*  / reaction / complex






 

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