ENSG00000130208


Homo sapiens

Features
Gene ID: ENSG00000130208
  
Biological name :APOC1
  
Synonyms : APOC1 / apolipoprotein C1 / P02654
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.32
Gene start: 44914247
Gene end: 44919349
  
Corresponding Affymetrix probe sets: 204416_x_at (Human Genome U133 Plus 2.0 Array)   213553_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000466227
Ensembl peptide - ENSP00000467368
Ensembl peptide - ENSP00000467504
Ensembl peptide - ENSP00000468029
Ensembl peptide - ENSP00000468276
Ensembl peptide - ENSP00000465190
Ensembl peptide - ENSP00000465356
Ensembl peptide - ENSP00000465710
Ensembl peptide - ENSP00000466146
NCBI entrez gene - 341     See in Manteia.
OMIM - 107710
RefSeq - NM_001321066
RefSeq - NM_001645
RefSeq - NM_001321065
RefSeq Peptide - NP_001307994
RefSeq Peptide - NP_001307995
RefSeq Peptide - NP_001636
swissprot - P02654
swissprot - A0A024R0T8
swissprot - K7EJI9
swissprot - K7EKP1
swissprot - K7ELM9
swissprot - K7ELU7
swissprot - K7EPF9
swissprot - K7EPR9
swissprot - K7ERI9
Ensembl - ENSG00000130208
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Apoc1ENSMUSG00000040564Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006781  Apolipoprotein C-I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process TAS
 biological_processGO:0006641 triglyceride metabolic process IEA
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0010873 positive regulation of cholesterol esterification TAS
 biological_processGO:0010900 negative regulation of phosphatidylcholine catabolic process IDA
 biological_processGO:0010916 negative regulation of very-low-density lipoprotein particle clearance IDA
 biological_processGO:0032374 regulation of cholesterol transport IC
 biological_processGO:0032375 negative regulation of cholesterol transport IDA
 biological_processGO:0033344 cholesterol efflux IDA
 biological_processGO:0033700 phospholipid efflux IDA
 biological_processGO:0034369 plasma lipoprotein particle remodeling IDA
 biological_processGO:0034375 high-density lipoprotein particle remodeling TAS
 biological_processGO:0034379 very-low-density lipoprotein particle assembly TAS
 biological_processGO:0034382 chylomicron remnant clearance IDA
 biological_processGO:0034447 very-low-density lipoprotein particle clearance TAS
 biological_processGO:0042157 lipoprotein metabolic process IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0045717 negative regulation of fatty acid biosynthetic process IDA
 biological_processGO:0045833 negative regulation of lipid metabolic process IDA
 biological_processGO:0048261 negative regulation of receptor-mediated endocytosis IDA
 biological_processGO:0050995 negative regulation of lipid catabolic process IDA
 biological_processGO:0051005 negative regulation of lipoprotein lipase activity IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0034361 very-low-density lipoprotein particle IDA
 cellular_componentGO:0034364 high-density lipoprotein particle IDA
 cellular_componentGO:0042627 chylomicron TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004859 phospholipase inhibitor activity IDA
 molecular_functionGO:0005504 fatty acid binding IDA
 molecular_functionGO:0031210 phosphatidylcholine binding TAS
 molecular_functionGO:0055102 lipase inhibitor activity IDA
 molecular_functionGO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity TAS


Pathways (from Reactome)
Pathway description
VLDL assembly
VLDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105699 LSR / Q86X29 / lipolysis stimulated lipoprotein receptor  / complex / reaction
 ENSG00000184730 APOBR / Q0VD83 / apolipoprotein B receptor  / complex / reaction
 ENSG00000147852 VLDLR / P98155 / very low density lipoprotein receptor  / reaction / complex
 ENSG00000267467 APOC4 / P55056 / apolipoprotein C4  / reaction / complex






 

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