ENSMUSG00000001247


Mus musculus

Features
Gene ID: ENSMUSG00000001247
  
Biological name :Lsr
  
Synonyms : Lipolysis-stimulated lipoprotein receptor / Lsr / Q99KG5
  
Possible biological names infered from orthology : Q86X29
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B1
Gene start: 30957770
Gene end: 30973464
  
Corresponding Affymetrix probe sets: 10562181 (MoGene1.0st)   1447690_at (Mouse Genome 430 2.0 Array)   1451255_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096153
Ensembl peptide - ENSMUSP00000123487
Ensembl peptide - ENSMUSP00000146120
Ensembl peptide - ENSMUSP00000001279
Ensembl peptide - ENSMUSP00000103751
NCBI entrez gene - 54135     See in Manteia.
MGI - MGI:1927471
RefSeq - XM_011250633
RefSeq - NM_001164184
RefSeq - NM_001164185
RefSeq - NM_017405
RefSeq - XM_011250631
RefSeq - XM_011250632
RefSeq Peptide - NP_059101
RefSeq Peptide - NP_001157656
RefSeq Peptide - NP_001157657
swissprot - Q99KG5
swissprot - D3YYU9
Ensembl - ENSMUSG00000001247
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lsrENSDARG00000099291Danio rerio
 LSRENSG00000105699Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ildr2 / B5TVM2 / Immunoglobulin-like domain-containing receptor 2 / Q71H61*ENSMUSG0000004061235
Ildr1 / Q8CBR1 / Immunoglobulin-like domain-containing receptor 1 / Q86SU0*ENSMUSG0000002290023


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR008664  LISCH7
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IMP
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0019216 regulation of lipid metabolic process IEA
 biological_processGO:0042953 lipoprotein transport TAS
 biological_processGO:0060856 establishment of blood-brain barrier IMP
 biological_processGO:0061833 protein localization to tricellular tight junction IDA
 biological_processGO:1904274 tricellular tight junction assembly IMP
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034361 very-low-density lipoprotein particle IEA
 cellular_componentGO:0034362 low-density lipoprotein particle IEA
 cellular_componentGO:0042627 chylomicron IEA
 cellular_componentGO:0061689 tricellular tight junction IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030169 low-density lipoprotein particle binding TAS
 molecular_functionGO:0030228 lipoprotein particle receptor activity TAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
Show

Allelic Composition: Nkx2-5tm1Siz/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nkx2-5tm1Siz/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nkx2-5tm1Siz/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Nkx2-5tm1Siz/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nkx2-5tm1Siz/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nkx2-5tm1Siz/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Nkx2-5tm1Siz/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001247 Lsr / Q99KG5 / Lipolysis-stimulated lipoprotein receptor / Q86X29*  / complex
 ENSMUSG00000074336 Apoc4 / Q61268 / Apolipoprotein C-IV / P55056* / APOC4-APOC2* / apolipoprotein C4* / APOC4-APOC2 readthrough (NMD candidate)*  / complex / reaction
 ENSMUSG00000040564 Apoc1 / P34928 / Apolipoprotein C-I Truncated apolipoprotein C-I / P02654* / apolipoprotein C1*  / reaction / complex






 

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