ENSMUSG00000022900


Mus musculus

Features
Gene ID: ENSMUSG00000022900
  
Biological name :Ildr1
  
Synonyms : Ildr1 / Immunoglobulin-like domain-containing receptor 1 / Q8CBR1
  
Possible biological names infered from orthology : Q86SU0
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B3
Gene start: 36693978
Gene end: 36726804
  
Corresponding Affymetrix probe sets: 10435514 (MoGene1.0st)   1423276_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023617
Ensembl peptide - ENSMUSP00000087045
Ensembl peptide - ENSMUSP00000112539
NCBI entrez gene - 106347     See in Manteia.
MGI - MGI:2146574
RefSeq - XM_006521674
RefSeq - NM_001285788
RefSeq - NM_001285791
RefSeq - NM_134109
RefSeq Peptide - NP_001272720
RefSeq Peptide - NP_598870
RefSeq Peptide - NP_001272717
swissprot - Q8CBR1
Ensembl - ENSMUSG00000022900
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ildr1aENSDARG00000103929Danio rerio
 ildr1bENSDARG00000040910Danio rerio
 ILDR1ENSGALG00000015136Gallus gallus
 ILDR1ENSG00000145103Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ildr2 / B5TVM2 / Immunoglobulin-like domain-containing receptor 2 / Q71H61*ENSMUSG0000004061226
Lsr / Q99KG5 / Lipolysis-stimulated lipoprotein receptor / Q86X29*ENSMUSG0000000124725


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008664  LISCH7
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0051260 protein homooligomerization ISO
 biological_processGO:0090277 positive regulation of peptide hormone secretion IDA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0061689 tricellular tight junction IDA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0070506 high-density lipoprotein particle receptor activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000026 abnormal inner ear morphology "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
Show

Allelic Composition: Alx4Lst-2J/Alx4+
Genetic Background: C57BL/6J-Alx4Lst-2J/J

 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lamp2tm1Amcu/Y,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J

Allelic Composition: Ildr1Gt(D178D03)Wrst/Ildr1Gt(D178D03)Wrst
Genetic Background: involves: 129S2/SvPas * Swiss Webster

 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fbxo11tm2a(EUCOMM)Wtsi/Fbxo11tm2a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lhcgrtm1.1Pnara/Lhcgr+
Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0001967 deafness "inability to hear" [J:57651]
Show

Allelic Composition: Lamp2tm1Amcu/Y,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J

Allelic Composition: Ildr1Gt(D178D03)Wrst/Ildr1Gt(D178D03)Wrst
Genetic Background: involves: 129S2/SvPas * Swiss Webster

Allelic Composition: Ildr1tm1.1Lwa/Ildr1tm1.1Lwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ildr1Gt(D178D03)Wrst/Ildr1Gt(D178D03)Wrst
Genetic Background: involves: 129S2/SvPas * Swiss Webster

 MP:0002630 abnormal endocochlear potential "alterations in the electrical potential difference between the endolymphatic and perilymphatic compartments of the cochlea" [J:80917, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lamp2tm1Amcu/Y,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J

Allelic Composition: Ildr1Gt(D178D03)Wrst/Ildr1Gt(D178D03)Wrst
Genetic Background: involves: 129S2/SvPas * Swiss Webster

 MP:0003151 absent tunnel of Corti "complete absence of the triangular, fluid-filled space normally found between the inner and outer rows of supporting pillar cells in the organ of Corti" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:32991]
Show

Allelic Composition: Ildr1tm1.1Lwa/Ildr1tm1.1Lwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lamp2tm1Amcu/Y,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J

Allelic Composition: Ildr1Gt(D178D03)Wrst/Ildr1Gt(D178D03)Wrst
Genetic Background: involves: 129S2/SvPas * Swiss Webster

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lamp2tm1Amcu/Y,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J

Allelic Composition: Ildr1Gt(D178D03)Wrst/Ildr1Gt(D178D03)Wrst
Genetic Background: involves: 129S2/SvPas * Swiss Webster

Allelic Composition: Ildr1tm1.1Lwa/Ildr1tm1.1Lwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004527 abnormal outer hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ildr1Gt(D178D03)Wrst/Ildr1Gt(D178D03)Wrst
Genetic Background: involves: 129S2/SvPas * Swiss Webster

 MP:0004532 abnormal inner hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typically linear or U-shaped pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear IHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lamp2tm1Amcu/Y,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0004737 absent distortion product otoacoustic emissions "failure to create mechanical distortions in the inner ear when two primary tones are presented, indicating failure of outer hair cells to amplify basilar membrane motion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ildr1Gt(D178D03)Wrst/Ildr1Gt(D178D03)Wrst
Genetic Background: involves: 129S2/SvPas * Swiss Webster

 MP:0004740 sensorineural hearing loss "a form of progressive hearing loss due to a lesion of the auditory division of cranial nerve VIII or the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lamp2tm1Amcu/Y,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lhcgrtm1.1Pnara/Lhcgr+
Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Ildr1Gt(D178D03)Wrst/Ildr1Gt(D178D03)Wrst,Tg(Cck-EGFP)BJ203Gsat/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * FVB/NTac * Swiss Webster

 MP:0006358 absent pinna reflex "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

Allelic Composition: Ildr1tm1(KOMP)Wtsi/Ildr1tm1(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Ildr1Gt(D178D03)Wrst/Ildr1Gt(D178D03)Wrst
Genetic Background: involves: 129S2/SvPas * Swiss Webster

Allelic Composition: Ildr1tm1.1Lwa/Ildr1tm1.1Lwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0013808 abnormal tunnel of Corti morphology "any structrual anomaly of the triangular, fluid-filled space normally found between the inner and outer rows of supporting pillar cells in the organ of Corti" [MGI:Anna]
Show

Allelic Composition: Ildr1tm1.1Lwa/Ildr1tm1.1Lwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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