ENSG00000153993


Homo sapiens

Features
Gene ID: ENSG00000153993
  
Biological name :SEMA3D
  
Synonyms : O95025 / SEMA3D / semaphorin 3D
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q21.11
Gene start: 84995553
Gene end: 85186855
  
Corresponding Affymetrix probe sets: 215324_at (Human Genome U133 Plus 2.0 Array)   215643_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000401366
Ensembl peptide - ENSP00000284136
NCBI entrez gene - 223117     See in Manteia.
OMIM - 609907
RefSeq - XM_017011873
RefSeq - NM_152754
RefSeq - XM_011515960
RefSeq - XM_011515961
RefSeq Peptide - NP_689967
swissprot - C9JYT6
swissprot - O95025
Ensembl - ENSG00000153993
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sema3dENSDARG00000017369Danio rerio
 Q90663ENSGALG00000006563Gallus gallus
 Q8BH34ENSMUSG00000040254Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q14563 / SEMA3A / semaphorin 3AENSG0000007521353
O15041 / SEMA3E / semaphorin 3EENSG0000017038145
Q13275 / SEMA3F / semaphorin 3FENSG0000000161744
Q13214 / SEMA3B / semaphorin 3BENSG0000001217144
Q9NS98 / SEMA3G / semaphorin 3GENSG0000001031943
Q99985 / SEMA3C / semaphorin 3CENSG0000007522343
Q92854 / SEMA4D / semaphorin 4DENSG0000018776429
Q9C0C4 / SEMA4C / semaphorin 4CENSG0000016875829
SEMA4B / semaphorin 4BENSG0000018503329
Q9NTN9 / SEMA4G / semaphorin 4GENSG0000009553929
O95754 / SEMA4F / ssemaphorin 4FENSG0000013562227
Q9H3S1 / SEMA4A / semaphorin 4AENSG0000019618927


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR027231  Semaphorin
 IPR036179  Immunoglobulin-like domain superfamily
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0050919 negative chemotaxis IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0038191 neuropilin binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000407 Hearing loss, sensorineural "Hearing loss caused by damage or dysfunction of the auditory nerve (cranial nerve VIII)." [HPO:curators]
Show

 HP:0001181 Adducted thumbs 
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 HP:0001249 Mental retardation 
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 HP:0001531 Failure to thrive in infancy 
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 HP:0001824 Weight loss 
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 HP:0002014 Diarrhea 
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 HP:0002017 Nausea and vomiting 
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 HP:0002019 Constipation 
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 HP:0002027 Abdominal pain 
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 HP:0002251 Congenital megacolon "An abnormality resulting from a lack of intestinal ganglion cells (i.e., an aganglionic section of bowel) that results in bowel obstruction with enlargement of the colon." [HPO:curators]
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 HP:0004322 Decreased body height "A height below that which is expected according to age and gender norms. Although there is no universally accepted definition of short stature, many refer to "short stature" as height more than 2 standard deviations below the mean for age and gender (or below the 3rd percentile for age and gender dependent norms)." [HPO:curators]
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 HP:0005214 Intestinal obstruction 
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 HP:0100031 Neoplasm of the thyroid gland "The presence of a `neoplasm` (MPATH:218) of the `thyroid gland` (FMA:9603)." [HPO:probinson]
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 HP:0100806 Sepsis 
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 HP:0200008 Multiple intestinal polyps 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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