ENSMUSG00000040782


Mus musculus

Features
Gene ID: ENSMUSG00000040782
  
Biological name :Cop1
  
Synonyms : Cop1 / COP1, E3 ubiquitin ligase / Q9R1A8
  
Possible biological names infered from orthology : Q8NHY2
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H1
Gene start: 159232320
Gene end: 159347640
  
Corresponding Affymetrix probe sets: 10350923 (MoGene1.0st)   10606160 (MoGene1.0st)   1426912_at (Mouse Genome 430 2.0 Array)   1438821_at (Mouse Genome 430 2.0 Array)   1446703_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000076160
Ensembl peptide - ENSMUSP00000142031
Ensembl peptide - ENSMUSP00000141941
Ensembl peptide - ENSMUSP00000141561
Ensembl peptide - ENSMUSP00000141490
Ensembl peptide - ENSMUSP00000141285
Ensembl peptide - ENSMUSP00000141200
NCBI entrez gene - 26374     See in Manteia.
MGI - MGI:1347046
RefSeq - XM_006496861
RefSeq - NM_011931
RefSeq - XM_006496859
RefSeq - XM_006496860
RefSeq Peptide - NP_036061
swissprot - A0A0A6YXD2
swissprot - A0A0A6YXK6
swissprot - Q9R1A8
swissprot - A0A0A6YWI1
swissprot - A0A0A6YWC5
swissprot - A0A0A6YVP2
swissprot - A0A0A6YVV7
Ensembl - ENSMUSG00000040782
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cop1ENSDARG00000079329Danio rerio
 COP1ENSGALG00000004500Gallus gallus
 COP1ENSG00000143207Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017907  Zinc finger, RING-type, conserved site
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0031464 Cul4A-RING E3 ubiquitin ligase complex IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
Autodegradation of the E3 ubiquitin ligase COP1
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Rc3h1tm1.2Mass/Rc3h1tm1.2Mass
Genetic Background: involves: C57BL/6 * CBA * CD-1 * NZB * SJL

Allelic Composition: Cop1Gt(XR0653)Wtsi/Cop1Gt(XR0653)Wtsi
Genetic Background: involves: 129P2/OlaHsd

 MP:0000373 belly spot "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cop1Gt(XR0653)Wtsi/Cop1Gt(XR0653)Wtsi
Genetic Background: involves: 129P2/OlaHsd

 MP:0000659 prostate gland hyperplasia "increased cell number in the prostate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63764]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cop1tm2.1Vmd/Cop1tm2.1Vmd,Tg(Pbsn-cre)4Prb/0
Genetic Background: B6N.CgCop1tm2.1Vmd Ptentm1Hwu Tg(Pbsn-cre)4Prb

Allelic Composition: Cop1tm2.1Vmd/Cop1+,Tg(Pbsn-cre)4Prb/0
Genetic Background: B6N.Cg-Cop1tm2.1Vmd Tg(Pbsn-cre)4Prb

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cop1Gt(XR0653)Wtsi/Cop1Gt(XR0653)Wtsi
Genetic Background: involves: 129P2/OlaHsd

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Cop1Gt(XR0653)Wtsi/Cop1Gt(XR0653)Wtsi
Genetic Background: involves: 129P2/OlaHsd

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Cop1Gt(XR0653)Wtsi/Cop1Gt(XR0653)Wtsi
Genetic Background: involves: 129P2/OlaHsd

 MP:0002021 increased incidence of induced tumors "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427]
Show

Allelic Composition: Cop1Gt(XR0653)Wtsi/Cop1Gt(XR0653)Wtsi
Genetic Background: involves: 129P2/OlaHsd

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cop1Gt(XR0653)Wtsi/Cop1Gt(XR0653)Wtsi
Genetic Background: involves: 129P2/OlaHsd

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cop1Gt(XR0653)Wtsi/Cop1Gt(XR0653)Wtsi
Genetic Background: involves: 129P2/OlaHsd

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cop1Gt(XR0653)Wtsi/Cop1Gt(XR0653)Wtsi
Genetic Background: involves: 129P2/OlaHsd

 MP:0003607 abnormal prostate physiology "malfunction of the gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cop1tm2.1Vmd/Cop1tm2.1Vmd,Tg(Pbsn-cre)4Prb/0
Genetic Background: B6N.Cg-Cop1tm2.1Vmd Tg(Pbsn-cre)4Prb

 MP:0004478 testicular teratoma "neoplasms found in the testis that are composed of multiple tissue types; includes types not normally found in tesis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cop1Gt(XR0653)Wtsi/Cop1Gt(XR0653)Wtsi
Genetic Background: involves: 129P2/OlaHsd

 MP:0009219 prostate intraepithelial neoplasia "noninvasive prostate duct lesions that affect smaller caliber ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cop1tm2.1Vmd/Cop1tm2.1Vmd,Tg(Pbsn-cre)4Prb/0
Genetic Background: B6N.CgCop1tm2.1Vmd Ptentm1Hwu Tg(Pbsn-cre)4Prb

Allelic Composition: Cop1tm2.1Vmd/Cop1tm2.1Vmd,Tg(Pbsn-cre)4Prb/0
Genetic Background: B6N.Cg-Cop1tm2.1Vmd Tg(Pbsn-cre)4Prb

 MP:0009220 prostate adenocarcinoma "malignant neoplasm arising from prostate tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cop1tm2.1Vmd/Cop1tm2.1Vmd,Tg(Pbsn-cre)4Prb/0
Genetic Background: B6N.CgCop1tm2.1Vmd Ptentm1Hwu Tg(Pbsn-cre)4Prb

 MP:0009222 uterus tumor "presence of abnormal rapidly proliferating cells in the uterus, usually in the form of a distinct mass" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cop1Gt(XR0653)Wtsi/Cop1Gt(XR0653)Wtsi
Genetic Background: involves: 129P2/OlaHsd

 MP:0009321 histiocytic sarcoma 
Show

Allelic Composition: Cop1Gt(XR0653)Wtsi/Cop1Gt(XR0653)Wtsi
Genetic Background: involves: 129P2/OlaHsd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Rc3h1tm1.2Mass/Rc3h1tm1.2Mass
Genetic Background: involves: C57BL/6 * CBA * CD-1 * NZB * SJL

Allelic Composition: Cop1Gt(XR0653)Wtsi/Cop1Gt(XR0653)Wtsi
Genetic Background: involves: 129P2/OlaHsd

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cop1Gt(XR0653)Wtsi/Cop1Gt(XR0653)Wtsi
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / complex
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr