ENSG00000143207


Homo sapiens

Features
Gene ID: ENSG00000143207
  
Biological name :COP1
  
Synonyms : COP1 / COP1, E3 ubiquitin ligase / Q8NHY2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q25.2
Gene start: 175944831
Gene end: 176207493
  
Corresponding Affymetrix probe sets: 1552617_a_at (Human Genome U133 Plus 2.0 Array)   234950_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433810
Ensembl peptide - ENSP00000433517
Ensembl peptide - ENSP00000437212
Ensembl peptide - ENSP00000437275
Ensembl peptide - ENSP00000310943
Ensembl peptide - ENSP00000356638
Ensembl peptide - ENSP00000356639
Ensembl peptide - ENSP00000356641
NCBI entrez gene - 64326     See in Manteia.
OMIM - 608067
RefSeq - XM_017002080
RefSeq - XM_017002070
RefSeq - XM_017002071
RefSeq - XM_017002072
RefSeq - XM_017002073
RefSeq - XM_017002074
RefSeq - XM_017002075
RefSeq - XM_017002076
RefSeq - XM_017002078
RefSeq - XM_017002079
RefSeq - NM_001001740
RefSeq - NM_001286644
RefSeq - NM_022457
RefSeq - XM_005245447
RefSeq - XM_005245448
RefSeq - XM_006711487
RefSeq - XM_011509881
RefSeq - XM_017002059
RefSeq - XM_017002060
RefSeq - XM_017002061
RefSeq - XM_017002062
RefSeq - XM_017002063
RefSeq - XM_017002064
RefSeq - XM_017002065
RefSeq - XM_017002066
RefSeq - XM_017002067
RefSeq - XM_017002068
RefSeq - XM_017002069
RefSeq Peptide - NP_001273573
RefSeq Peptide - NP_071902
RefSeq Peptide - NP_001001740
swissprot - H0YF49
swissprot - E9PMW8
swissprot - Q8NHY2
swissprot - E9PJB5
swissprot - H0Y339
swissprot - H0Y340
Ensembl - ENSG00000143207
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cop1ENSDARG00000079329Danio rerio
 COP1ENSGALG00000004500Gallus gallus
 Cop1ENSMUSG00000040782Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017907  Zinc finger, RING-type, conserved site
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010212 response to ionizing radiation IDA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0043687 post-translational protein modification TAS
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0031464 Cul4A-RING E3 ubiquitin ligase complex IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IMP


Pathways (from Reactome)
Pathway description
Autodegradation of the E3 ubiquitin ligase COP1
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / reaction
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr