ENSG00000184845


Homo sapiens

Features
Gene ID: ENSG00000184845
  
Biological name :DRD1
  
Synonyms : dopamine receptor D1 / DRD1 / P21728
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q35.2
Gene start: 175440039
Gene end: 175444208
  
Corresponding Affymetrix probe sets: 214652_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000377353
NCBI entrez gene - 1812     See in Manteia.
OMIM - 126449
RefSeq - NM_000794
RefSeq Peptide - NP_000785
swissprot - P21728
Ensembl - ENSG00000184845
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 drd1aENSDARG00000071640Danio rerio
 drd1bENSDARG00000038918Danio rerio
 DRD1ENSGALG00000039698Gallus gallus
 Drd1ENSMUSG00000021478Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DRD5 / P21918 / dopamine receptor D5ENSG0000016967656
ADRB1 / P08588 / adrenoceptor beta 1ENSG0000004359131
ADRB2 / P07550 / adrenoceptor beta 2ENSG0000016925228
HTR6 / P50406 / 5-hydroxytryptamine receptor 6ENSG0000015874827
HRH2 / P25021 / histamine receptor H2ENSG0000011374927
ADRB3 / P13945 / adrenoceptor beta 3ENSG0000018877826
HTR2B / P41595 / 5-hydroxytryptamine receptor 2BENSG0000013591426
DRD2 / P14416 / dopamine receptor D2ENSG0000014929525
DRD3 / P35462 / dopamine receptor D3ENSG0000015157725
DRD4 / P21917 / dopamine receptor D4ENSG0000006969624
HTR2A / P28223 / 5-hydroxytryptamine receptor 2AENSG0000010246824
HTR2C / P28335 / 5-hydroxytryptamine receptor 2CENSG0000014724623


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000929  Dopamine receptor family
 IPR001413  Dopamine D1 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001659 temperature homeostasis IEA
 biological_processGO:0001661 conditioned taste aversion IEA
 biological_processGO:0001662 behavioral fear response IEA
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0001963 synaptic transmission, dopaminergic IEA
 biological_processGO:0001975 response to amphetamine IEA
 biological_processGO:0006606 protein import into nucleus IEA
 biological_processGO:0006936 muscle contraction IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IDA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007190 activation of adenylate cyclase activity IEA
 biological_processGO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway IDA
 biological_processGO:0007212 dopamine receptor signaling pathway IEA
 biological_processGO:0007416 synapse assembly ISS
 biological_processGO:0007612 learning IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0007617 mating behavior IEA
 biological_processGO:0007625 grooming behavior IEA
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0007628 adult walking behavior IEA
 biological_processGO:0007631 feeding behavior IEA
 biological_processGO:0008306 associative learning IEA
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0014002 astrocyte development IEA
 biological_processGO:0015872 dopamine transport IEA
 biological_processGO:0019226 transmission of nerve impulse IEA
 biological_processGO:0019228 neuronal action potential IEA
 biological_processGO:0021542 dentate gyrus development IEA
 biological_processGO:0021756 striatum development IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0021853 cerebral cortex GABAergic interneuron migration IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030432 peristalsis IEA
 biological_processGO:0035106 operant conditioning IEA
 biological_processGO:0042053 regulation of dopamine metabolic process IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042311 vasodilation IEA
 biological_processGO:0042417 dopamine metabolic process IC
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042711 maternal behavior IEA
 biological_processGO:0043268 positive regulation of potassium ion transport ISS
 biological_processGO:0043987 histone H3-S10 phosphorylation IEA
 biological_processGO:0046323 glucose import IEA
 biological_processGO:0046959 habituation IEA
 biological_processGO:0046960 sensitization IEA
 biological_processGO:0048148 behavioral response to cocaine IEA
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IDA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IDA
 biological_processGO:0051584 regulation of dopamine uptake involved in synaptic transmission IC
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0060134 prepulse inhibition ISS
 biological_processGO:0060158 phospholipase C-activating dopamine receptor signaling pathway IDA
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0060292 long term synaptic depression IEA
 biological_processGO:0071870 cellular response to catecholamine stimulus IDA
 biological_processGO:1903351 cellular response to dopamine IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IC
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0060170 ciliary membrane IDA
 cellular_componentGO:0097730 non-motile cilium IDA
 molecular_functionGO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs IMP
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004952 dopamine neurotransmitter receptor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035240 dopamine binding IMP


Pathways (from Reactome)
Pathway description
Dopamine receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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