ENSG00000149295


Homo sapiens

Features
Gene ID: ENSG00000149295
  
Biological name :DRD2
  
Synonyms : dopamine receptor D2 / DRD2 / P14416
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q23.2
Gene start: 113409615
Gene end: 113475691
  
Corresponding Affymetrix probe sets: 206590_x_at (Human Genome U133 Plus 2.0 Array)   211624_s_at (Human Genome U133 Plus 2.0 Array)   216924_s_at (Human Genome U133 Plus 2.0 Array)   216938_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000438215
Ensembl peptide - ENSP00000438419
Ensembl peptide - ENSP00000442172
Ensembl peptide - ENSP00000441474
Ensembl peptide - ENSP00000441068
Ensembl peptide - ENSP00000278597
Ensembl peptide - ENSP00000354859
NCBI entrez gene - 1813     See in Manteia.
OMIM - 126450
RefSeq - XM_017017296
RefSeq - NM_000795
RefSeq - NM_016574
RefSeq Peptide - NP_057658
RefSeq Peptide - NP_000786
swissprot - A0A1Y8EK52
swissprot - P14416
swissprot - A0A024R3I6
swissprot - F8VUV1
swissprot - A0A024R3C5
swissprot - Q6LDH7
Ensembl - ENSG00000149295
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 drd2aENSDARG00000056926Danio rerio
 drd2bENSDARG00000011091Danio rerio
 DRD2ENSGALG00000007794Gallus gallus
 Drd2ENSMUSG00000032259Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DRD3 / P35462 / dopamine receptor D3ENSG0000015157750
DRD4 / P21917 / dopamine receptor D4ENSG0000006969633
DRD5 / P21918 / dopamine receptor D5ENSG0000016967628
DRD1 / P21728 / dopamine receptor D1ENSG0000018484526
HTR2C / P28335 / 5-hydroxytryptamine receptor 2CENSG0000014724626
HTR2B / P41595 / 5-hydroxytryptamine receptor 2BENSG0000013591426
ADRB1 / P08588 / adrenoceptor beta 1ENSG0000004359125
HTR2A / P28223 / 5-hydroxytryptamine receptor 2AENSG0000010246825
HRH2 / P25021 / histamine receptor H2ENSG0000011374924
ADRB2 / P07550 / adrenoceptor beta 2ENSG0000016925224
HTR6 / P50406 / 5-hydroxytryptamine receptor 6ENSG0000015874824
ADRB3 / P13945 / adrenoceptor beta 3ENSG0000018877823


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000929  Dopamine receptor family
 IPR001922  Dopamine D2 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001659 temperature homeostasis ISS
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001963 synaptic transmission, dopaminergic IBA
 biological_processGO:0001964 startle response IEA
 biological_processGO:0001975 response to amphetamine ISS
 biological_processGO:0001976 neurological system process involved in regulation of systemic arterial blood pressure ISS
 biological_processGO:0002027 regulation of heart rate ISS
 biological_processGO:0002028 regulation of sodium ion transport ISS
 biological_processGO:0002031 G-protein coupled receptor internalization IEA
 biological_processGO:0002052 positive regulation of neuroblast proliferation ISS
 biological_processGO:0002092 positive regulation of receptor internalization IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007194 negative regulation of adenylate cyclase activity IBA
 biological_processGO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway IDA
 biological_processGO:0007212 dopamine receptor signaling pathway IEA
 biological_processGO:0007270 neuron-neuron synaptic transmission ISS
 biological_processGO:0007409 axonogenesis ISS
 biological_processGO:0007416 synapse assembly ISS
 biological_processGO:0007608 sensory perception of smell ISS
 biological_processGO:0007616 long-term memory IEA
 biological_processGO:0007625 grooming behavior IEA
 biological_processGO:0007626 locomotory behavior ISS
 biological_processGO:0007628 adult walking behavior ISS
 biological_processGO:0007631 feeding behavior IEA
 biological_processGO:0008104 protein localization ISS
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0008306 associative learning ISS
 biological_processGO:0008542 visual learning ISS
 biological_processGO:0009416 response to light stimulus ISS
 biological_processGO:0009636 response to toxic substance IBA
 biological_processGO:0010039 response to iron ion IEA
 biological_processGO:0014059 regulation of dopamine secretion IBA
 biological_processGO:0014854 response to inactivity IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0021756 striatum development IEA
 biological_processGO:0021769 orbitofrontal cortex development IEA
 biological_processGO:0021853 cerebral cortex GABAergic interneuron migration ISS
 biological_processGO:0021984 adenohypophysis development ISS
 biological_processGO:0030336 negative regulation of cell migration ISS
 biological_processGO:0030432 peristalsis ISS
 biological_processGO:0030534 adult behavior IEA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0031223 auditory behavior IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032228 regulation of synaptic transmission, GABAergic ISS
 biological_processGO:0032467 positive regulation of cytokinesis IMP
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0033602 negative regulation of dopamine secretion IEA
 biological_processGO:0034776 response to histamine IDA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0035810 positive regulation of urine volume IEA
 biological_processGO:0035815 positive regulation of renal sodium excretion IEA
 biological_processGO:0040018 positive regulation of multicellular organism growth IEA
 biological_processGO:0042220 response to cocaine ISS
 biological_processGO:0042321 negative regulation of circadian sleep/wake cycle, sleep IEA
 biological_processGO:0042417 dopamine metabolic process IC
 biological_processGO:0042493 response to drug ISS
 biological_processGO:0043266 regulation of potassium ion transport ISS
 biological_processGO:0043278 response to morphine ISS
 biological_processGO:0043408 regulation of MAPK cascade IEA
 biological_processGO:0043473 pigmentation IEA
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0045776 negative regulation of blood pressure ISS
 biological_processGO:0045824 negative regulation of innate immune response IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0046717 acid secretion IEA
 biological_processGO:0048148 behavioral response to cocaine ISS
 biological_processGO:0048149 behavioral response to ethanol ISS
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity ISS
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0048755 branching morphogenesis of a nerve ISS
 biological_processGO:0050482 arachidonic acid secretion IDA
 biological_processGO:0050709 negative regulation of protein secretion IDA
 biological_processGO:0050804 modulation of chemical synaptic transmission IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol ISS
 biological_processGO:0051481 negative regulation of cytosolic calcium ion concentration IBA
 biological_processGO:0051584 regulation of dopamine uptake involved in synaptic transmission IC
 biological_processGO:0051586 positive regulation of dopamine uptake involved in synaptic transmission ISS
 biological_processGO:0051823 regulation of synapse structural plasticity IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling NAS
 biological_processGO:0051967 negative regulation of synaptic transmission, glutamatergic ISS
 biological_processGO:0060079 excitatory postsynaptic potential NAS
 biological_processGO:0060124 positive regulation of growth hormone secretion ISS
 biological_processGO:0060134 prepulse inhibition ISS
 biological_processGO:0060158 phospholipase C-activating dopamine receptor signaling pathway IGI
 biological_processGO:0060160 negative regulation of dopamine receptor signaling pathway ISS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0090325 regulation of locomotion involved in locomotory behavior IEA
 biological_processGO:1900168 positive regulation of glial cell-derived neurotrophic factor secretion IDA
 biological_processGO:1900273 positive regulation of long-term synaptic potentiation IEA
 biological_processGO:1901386 negative regulation of voltage-gated calcium channel activity IBA
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0030139 endocytic vesicle IEA
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0030672 synaptic vesicle membrane IBA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0036126 sperm flagellum IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0060170 ciliary membrane IDA
 cellular_componentGO:0097730 non-motile cilium IDA
 molecular_functionGO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004952 dopamine neurotransmitter receptor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008144 drug binding IDA
 molecular_functionGO:0035240 dopamine binding IBA
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Dopamine receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0000473 Torticollis 
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 HP:0000716 Depression "A condition characterized by pervasive dysphoric mood, loss of interests, and inability to experience pleasure." [HPO:curators]
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 HP:0000722 Obsessive-compulsive disorder 
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 HP:0000739 Anxiety 
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 HP:0000756 Agoraphobia 
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 HP:0001290 Generalized hypotonia "Generalized muscular hypotonia (abnormally low muscle tone)." [HPO:curators]
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 HP:0001336 Myoclonus "Very brief, involuntary random muscular contractions occurring at rest, in response to sensory stimuli, or accompanying voluntary movements." [HPO:curators]
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 HP:0001337 Tremor "An unintentional, oscillating to-and-fro muscle movement." [HPO:curators]
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 HP:0002356 Writer s cramp 
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 HP:0003621 Juvenile onset 
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 HP:0003829 Incomplete penetrance 
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 HP:0010531 Spinal myoclonus "Spinal myoclonus is generally due to a tumor, infection, injury, or degenerative process of the spinal cord, and is characterized by involuntary rhythmic muscle contractions, usually at a rate of more than one per second. Myoclonus occurs synchronously in several muscles and can be increased in severity and frequency by fatigue or stress, but is usually unaffected by sensory stimuli. Spinal myoclonus ceases during sleep or anesthesia." [HPO:curators]
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 HP:0012075 Personality disorder "An abnormality of mental functioning affecting the personality and behavioural tendencies of an individual and characterized by a rigid and unhealthy pattern of thinking and behavior. The definition of a personal disorder implies that the abnormality is not the result of damage or insult to the brain or from another psychiatric disorder." [HPO:probinson]
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 HP:0025269 Panic attack "A sudden episode of intense fear in a situation in which there is no danger or apparent cause. The panic attack is accompanied by symptoms such as palpitations, sweating and chills or hot flushes. There may be a sensation of dyspnea (being out of breath), chest pain, or abdominal distress. Some indiviudals with panic attacks may experience depersonalization, a fear of going crazy, or a fear of dying." []
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 HP:0045084 Limb myoclonus 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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