ENSG00000147246


Homo sapiens

Features
Gene ID: ENSG00000147246
  
Biological name :HTR2C
  
Synonyms : 5-hydroxytryptamine receptor 2C / HTR2C / P28335
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: q23
Gene start: 114584078
Gene end: 114910061
  
Corresponding Affymetrix probe sets: 207307_at (Human Genome U133 Plus 2.0 Array)   211479_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000276198
Ensembl peptide - ENSP00000361018
Ensembl peptide - ENSP00000361019
NCBI entrez gene - 3358     See in Manteia.
OMIM - 312861
RefSeq - NM_001256760
RefSeq - NM_000868
RefSeq - NM_001256761
RefSeq Peptide - NP_000859
RefSeq Peptide - NP_001243689
RefSeq Peptide - NP_001243690
swissprot - P28335
Ensembl - ENSG00000147246
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 htr2cl1ENSDARG00000018228Danio rerio
 HTR2CENSGALG00000005853Gallus gallus
 Htr2cENSMUSG00000041380Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HTR2A / P28223 / 5-hydroxytryptamine receptor 2AENSG0000010246851
HTR2B / P41595 / 5-hydroxytryptamine receptor 2BENSG0000013591443
DRD2 / P14416 / dopamine receptor D2ENSG0000014929525
DRD3 / P35462 / dopamine receptor D3ENSG0000015157724
ADRB1 / P08588 / adrenoceptor beta 1ENSG0000004359124
ADRB2 / P07550 / adrenoceptor beta 2ENSG0000016925224
DRD1 / P21728 / dopamine receptor D1ENSG0000018484523
ADRB3 / P13945 / adrenoceptor beta 3ENSG0000018877823
DRD5 / P21918 / dopamine receptor D5ENSG0000016967623
DRD4 / P21917 / dopamine receptor D4ENSG0000006969622
HTR6 / P50406 / 5-hydroxytryptamine receptor 6ENSG0000015874822
HRH2 / P25021 / histamine receptor H2ENSG0000011374920


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000377  5-Hydroxytryptamine 2C receptor
 IPR002231  5-hydroxytryptamine receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response ISS
 biological_processGO:0006182 cGMP biosynthetic process IDA
 biological_processGO:0006874 cellular calcium ion homeostasis IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007208 phospholipase C-activating serotonin receptor signaling pathway ISS
 biological_processGO:0007210 serotonin receptor signaling pathway IMP
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0007610 behavior IEA
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0007631 feeding behavior ISS
 biological_processGO:0010513 positive regulation of phosphatidylinositol biosynthetic process IDA
 biological_processGO:0031644 regulation of neurological system process ISS
 biological_processGO:0032098 regulation of appetite ISS
 biological_processGO:0042493 response to drug IDA
 biological_processGO:0043397 regulation of corticotropin-releasing hormone secretion ISS
 biological_processGO:0045600 positive regulation of fat cell differentiation IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IMP
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway ISS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001587 Gq/11-coupled serotonin receptor activity IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004993 G-protein coupled serotonin receptor activity IDA
 molecular_functionGO:0008144 drug binding IDA
 molecular_functionGO:0030594 neurotransmitter receptor activity IBA
 molecular_functionGO:0051378 serotonin binding IDA
 molecular_functionGO:0071886 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding IDA


Pathways (from Reactome)
Pathway description
Serotonin receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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