ENSG00000151577


Homo sapiens

Features
Gene ID: ENSG00000151577
  
Biological name :DRD3
  
Synonyms : dopamine receptor D3 / DRD3 / P35462
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q13.31
Gene start: 114128652
Gene end: 114199407
  
Corresponding Affymetrix probe sets: 211625_s_at (Human Genome U133 Plus 2.0 Array)   214559_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000420662
Ensembl peptide - ENSP00000295881
Ensembl peptide - ENSP00000373169
Ensembl peptide - ENSP00000419402
NCBI entrez gene - 1814     See in Manteia.
OMIM - 126451
RefSeq - XM_017005829
RefSeq - NM_000796
RefSeq - NM_001282563
RefSeq - NM_001290809
RefSeq - NM_033663
RefSeq Peptide - NP_000787
RefSeq Peptide - NP_001269492
RefSeq Peptide - NP_001277738
RefSeq Peptide - NP_387512
swissprot - P35462
swissprot - X5D2G4
swissprot - E9PCM4
Ensembl - ENSG00000151577
  
Related genetic diseases (OMIM): 181500 - {Schizophrenia, susceptibility to}, 181500
  190300 - {Essential tremor, hereditary, 1}, 190300
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 drd3ENSDARG00000032131Danio rerio
 DRD3ENSGALG00000015117Gallus gallus
 Drd3ENSMUSG00000022705Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DRD2 / P14416 / dopamine receptor D2ENSG0000014929555
DRD4 / P21917 / dopamine receptor D4ENSG0000006969637
ADRB1 / P08588 / adrenoceptor beta 1ENSG0000004359129
ADRB3 / P13945 / adrenoceptor beta 3ENSG0000018877829
DRD5 / P21918 / dopamine receptor D5ENSG0000016967629
DRD1 / P21728 / dopamine receptor D1ENSG0000018484528
HTR2A / P28223 / 5-hydroxytryptamine receptor 2AENSG0000010246827
HTR2C / P28335 / 5-hydroxytryptamine receptor 2CENSG0000014724627
HTR2B / P41595 / 5-hydroxytryptamine receptor 2BENSG0000013591426
HTR6 / P50406 / 5-hydroxytryptamine receptor 6ENSG0000015874826
ADRB2 / P07550 / adrenoceptor beta 2ENSG0000016925226
HRH2 / P25021 / histamine receptor H2ENSG0000011374926


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000929  Dopamine receptor family
 IPR001620  Dopamine D3 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001963 synaptic transmission, dopaminergic IEA
 biological_processGO:0001975 response to amphetamine IEA
 biological_processGO:0002016 regulation of blood volume by renin-angiotensin IEA
 biological_processGO:0002031 G-protein coupled receptor internalization IDA
 biological_processGO:0006874 cellular calcium ion homeostasis IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway IEA
 biological_processGO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway IDA
 biological_processGO:0007212 dopamine receptor signaling pathway IEA
 biological_processGO:0007611 learning or memory NAS
 biological_processGO:0007612 learning NAS
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0014059 regulation of dopamine secretion IEA
 biological_processGO:0019216 regulation of lipid metabolic process IEA
 biological_processGO:0030814 obsolete regulation of cAMP metabolic process IEA
 biological_processGO:0032416 negative regulation of sodium:proton antiporter activity IEA
 biological_processGO:0032467 positive regulation of cytokinesis IMP
 biological_processGO:0032922 circadian regulation of gene expression IEA
 biological_processGO:0034776 response to histamine IDA
 biological_processGO:0035176 social behavior NAS
 biological_processGO:0035483 gastric emptying IEA
 biological_processGO:0035815 positive regulation of renal sodium excretion IEA
 biological_processGO:0040012 regulation of locomotion IEA
 biological_processGO:0040014 regulation of multicellular organism growth IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042417 dopamine metabolic process IC
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0045187 regulation of circadian sleep/wake cycle, sleep IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045776 negative regulation of blood pressure IEA
 biological_processGO:0045840 positive regulation of mitotic nuclear division IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046717 acid secretion IEA
 biological_processGO:0048148 behavioral response to cocaine IEA
 biological_processGO:0048715 negative regulation of oligodendrocyte differentiation IEA
 biological_processGO:0050482 arachidonic acid secretion IDA
 biological_processGO:0050709 negative regulation of protein secretion IDA
 biological_processGO:0050883 musculoskeletal movement, spinal reflex action IEA
 biological_processGO:0051584 regulation of dopamine uptake involved in synaptic transmission IC
 biological_processGO:0051898 negative regulation of protein kinase B signaling IEA
 biological_processGO:0060134 prepulse inhibition IMP
 biological_processGO:0060160 negative regulation of dopamine receptor signaling pathway IEA
 biological_processGO:0060161 positive regulation of dopamine receptor signaling pathway IEA
 biological_processGO:0090325 regulation of locomotion involved in locomotory behavior IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030139 endocytic vesicle IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045177 apical part of cell IEA
 molecular_functionGO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004952 dopamine neurotransmitter receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031748 D1 dopamine receptor binding IEA
 molecular_functionGO:0035240 dopamine binding IEA


Pathways (from Reactome)
Pathway description
Dopamine receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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