ENSG00000102468


Homo sapiens

Features
Gene ID: ENSG00000102468
  
Biological name :HTR2A
  
Synonyms : 5-hydroxytryptamine receptor 2A / HTR2A / P28223
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q14.2
Gene start: 46831550
Gene end: 46897076
  
Corresponding Affymetrix probe sets: 207135_at (Human Genome U133 Plus 2.0 Array)   211616_s_at (Human Genome U133 Plus 2.0 Array)   244130_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000441861
Ensembl peptide - ENSP00000482708
Ensembl peptide - ENSP00000367959
Ensembl peptide - ENSP00000437737
NCBI entrez gene - 3356     See in Manteia.
OMIM - 182135
RefSeq - NM_000621
RefSeq - NM_001165947
RefSeq Peptide - NP_000612
RefSeq Peptide - NP_001159419
swissprot - A0A087WZJ9
swissprot - P28223
Ensembl - ENSG00000102468
  
Related genetic diseases (OMIM): 103780 - {Alcohol dependence, susceptibility to}, 103780
  164230 - {Obsessive-compulsive disorder, susceptibility to}, 164230
  181500 - {Schizophrenia, susceptibility to}, 181500
  606788 - {Anorexia nervosa, susceptibility to}, 606788
  608516 - {Major depressive disorder, response to citalopram therapy in}, 608516
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 htr2aaENSDARG00000057029Danio rerio
 htr2abENSDARG00000058165Danio rerio
 HTR2AENSGALG00000016992Gallus gallus
 Htr2aENSMUSG00000034997Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HTR2C / P28335 / 5-hydroxytryptamine receptor 2CENSG0000014724649
HTR2B / P41595 / 5-hydroxytryptamine receptor 2BENSG0000013591444
ADRB1 / P08588 / adrenoceptor beta 1ENSG0000004359124
DRD2 / P14416 / dopamine receptor D2ENSG0000014929524
DRD3 / P35462 / dopamine receptor D3ENSG0000015157723
DRD4 / P21917 / dopamine receptor D4ENSG0000006969622
DRD1 / P21728 / dopamine receptor D1ENSG0000018484522
HRH2 / P25021 / histamine receptor H2ENSG0000011374921
HTR6 / P50406 / 5-hydroxytryptamine receptor 6ENSG0000015874821
ADRB3 / P13945 / adrenoceptor beta 3ENSG0000018877821
DRD5 / P21918 / dopamine receptor D5ENSG0000016967621
ADRB2 / P07550 / adrenoceptor beta 2ENSG0000016925220


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000455  5-Hydroxytryptamine 2A receptor
 IPR002231  5-hydroxytryptamine receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001659 temperature homeostasis IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IDA
 biological_processGO:0006939 smooth muscle contraction IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007202 activation of phospholipase C activity IDA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007208 phospholipase C-activating serotonin receptor signaling pathway IEA
 biological_processGO:0007210 serotonin receptor signaling pathway TAS
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0007568 aging IEA
 biological_processGO:0007610 behavior IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0008219 cell death IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010513 positive regulation of phosphatidylinositol biosynthetic process IDA
 biological_processGO:0014059 regulation of dopamine secretion IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IDA
 biological_processGO:0014824 artery smooth muscle contraction IEA
 biological_processGO:0014832 urinary bladder smooth muscle contraction IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0030431 sleep IEA
 biological_processGO:0033674 positive regulation of kinase activity IEA
 biological_processGO:0042493 response to drug IDA
 biological_processGO:0043267 negative regulation of potassium ion transport IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0044380 protein localization to cytoskeleton IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation IEA
 biological_processGO:0045821 positive regulation of glycolytic process IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0046883 regulation of hormone secretion IEA
 biological_processGO:0048148 behavioral response to cocaine IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050795 regulation of behavior IEA
 biological_processGO:0050965 detection of temperature stimulus involved in sensory perception of pain IEA
 biological_processGO:0050966 detection of mechanical stimulus involved in sensory perception of pain IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IMP
 biological_processGO:0051967 negative regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0098664 G-protein coupled serotonin receptor signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043198 dendritic shaft IEA
 cellular_componentGO:0070852 cell body fiber IEA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004993 G-protein coupled serotonin receptor activity TAS
 molecular_functionGO:0008144 drug binding IDA
 molecular_functionGO:0030594 neurotransmitter receptor activity IBA
 molecular_functionGO:0051378 serotonin binding IDA
 molecular_functionGO:0071886 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding IDA


Pathways (from Reactome)
Pathway description
Serotonin receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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