ENSMUSG00000034997


Mus musculus

Features
Gene ID: ENSMUSG00000034997
  
Biological name :Htr2a
  
Synonyms : 5-hydroxytryptamine (serotonin) receptor 2A / Htr2a / P35363
  
Possible biological names infered from orthology : 5-hydroxytryptamine receptor 2A / P28223
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: D3
Gene start: 74640840
Gene end: 74709494
  
Corresponding Affymetrix probe sets: 10416406 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000047774
NCBI entrez gene - 15558     See in Manteia.
MGI - MGI:109521
RefSeq - NM_172812
RefSeq Peptide - NP_766400
swissprot - P35363
swissprot - Q543D4
Ensembl - ENSMUSG00000034997
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 htr2aaENSDARG00000057029Danio rerio
 htr2abENSDARG00000058165Danio rerio
 HTR2AENSGALG00000016992Gallus gallus
 HTR2AENSG00000102468Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Htr2c / P34968 / 5-hydroxytryptamine (serotonin) receptor 2C / P28335* / 5-hydroxytryptamine receptor 2C*ENSMUSG0000004138049
Htr2b / Q02152 / 5-hydroxytryptamine (serotonin) receptor 2B / P41595* / 5-hydroxytryptamine receptor 2B*ENSMUSG0000002622844
Drd2 / P61168 / D(2) dopamine receptor / P14416* / dopamine receptor D2*ENSMUSG0000003225924
Drd3 / P30728 / D(3) dopamine receptor / P35462* / dopamine receptor D3*ENSMUSG0000002270523
Drd1 / Q61616 / D(1A) dopamine receptor / P21728* / dopamine receptor D1*ENSMUSG0000002147823
Adrb1 / P34971 / Beta-1 adrenergic receptor / P08588* / adrenoceptor beta 1*ENSMUSG0000003528323
Drd4 / P51436 / D(4) dopamine receptor / P21917* / dopamine receptor D4*ENSMUSG0000002549621
Adrb2 / P18762 / Beta-2 adrenergic receptor / P07550* / adrenoceptor beta 2*ENSMUSG0000004573021
Hrh2 / P97292 / Histamine H2 receptor / P25021* / histamine receptor H2*ENSMUSG0000003498721
Htr6 / Q9R1C8 / 5-hydroxytryptamine (serotonin) receptor 6 / P50406* / 5-hydroxytryptamine receptor 6*ENSMUSG0000002874721
Drd5 / Q8BLD9 / D(1B) dopamine receptor / P21918* / dopamine receptor D5*ENSMUSG0000003935821
Adrb3 / P25962 / Beta-3 adrenergic receptor / P13945* / adrenoceptor beta 3*ENSMUSG0000003148920


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000455  5-Hydroxytryptamine 2A receptor
 IPR002231  5-hydroxytryptamine receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001659 temperature homeostasis IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0006939 smooth muscle contraction IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007202 activation of phospholipase C activity IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007208 phospholipase C-activating serotonin receptor signaling pathway IEA
 biological_processGO:0007210 serotonin receptor signaling pathway IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007610 behavior IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0008219 cell death IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010513 positive regulation of phosphatidylinositol biosynthetic process IEA
 biological_processGO:0014059 regulation of dopamine secretion IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0014824 artery smooth muscle contraction IEA
 biological_processGO:0014832 urinary bladder smooth muscle contraction IEA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0030431 sleep IEA
 biological_processGO:0033674 positive regulation of kinase activity IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043267 negative regulation of potassium ion transport IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0044380 protein localization to cytoskeleton IDA
 biological_processGO:0045600 positive regulation of fat cell differentiation IMP
 biological_processGO:0045821 positive regulation of glycolytic process IMP
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0046883 regulation of hormone secretion IEA
 biological_processGO:0048148 behavioral response to cocaine IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0050795 regulation of behavior IEA
 biological_processGO:0050965 detection of temperature stimulus involved in sensory perception of pain IEA
 biological_processGO:0050966 detection of mechanical stimulus involved in sensory perception of pain IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051967 negative regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043198 dendritic shaft IEA
 cellular_componentGO:0070852 cell body fiber IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004993 G-protein coupled serotonin receptor activity ISO
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0030594 neurotransmitter receptor activity IBA
 molecular_functionGO:0051378 serotonin binding IEA
 molecular_functionGO:0071886 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding IEA


Pathways (from Reactome)
Pathway description
Serotonin receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000479 abnormal intestinal cell "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ppardtm1Dsvg/Ppardtm1Dsvg
Genetic Background: involves: 129S2/SvPas

 MP:0001362 abnormal anxiety-related response "altered emotional response related to anticipation of a non-specific threat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Ak1tm1Bew/Ak1tm1Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Htr2atm1Grch/Htr2atm2Grch
Genetic Background: 129S6/SvEv-Htr2atm1Grch Htr2atm2Grch

Allelic Composition: Htr2atm1Grch/Htr2atm2Grch
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Htr2atm1Grch/Htr2atm2Grch,Slc6a4tm1(cre)Grch/Slc6a4+
Genetic Background: involves: 129S6/SvEvTac

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
Show

Allelic Composition: Ak1tm1Bew/Ak1tm1Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Htr2atm1Grch/Htr2atm2Grch
Genetic Background: 129S6/SvEv-Htr2atm1Grch Htr2atm2Grch

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ak1tm1Bew/Ak1tm1Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Htr2atm1Grch/Htr2atm2Grch
Genetic Background: 129S6/SvEv-Htr2atm1Grch Htr2atm2Grch

 MP:0008802 abnormal intestinal smooth muscle morphology "any structural anomaly of the nonstriated, involuntary muscle tissue lining the intestine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppardtm1Dsvg/Ppardtm1Dsvg
Genetic Background: involves: 129S2/SvPas

 MP:0013486 decreased Paneth cell number "fewer than normal numbers of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
Show

Allelic Composition: Ppardtm1Dsvg/Ppardtm1Dsvg
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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