ENSMUSG00000032259


Mus musculus

Features
Gene ID: ENSMUSG00000032259
  
Biological name :Drd2
  
Synonyms : D(2) dopamine receptor / Drd2 / P61168
  
Possible biological names infered from orthology : dopamine receptor D2 / P14416
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A5.3
Gene start: 49340627
Gene end: 49408177
  
Corresponding Affymetrix probe sets: 10585169 (MoGene1.0st)   1418950_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000075170
NCBI entrez gene - 13489     See in Manteia.
MGI - MGI:94924
RefSeq - NM_010077
RefSeq - XM_006509996
RefSeq Peptide - NP_034207
swissprot - P61168
Ensembl - ENSMUSG00000032259
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 drd2aENSDARG00000056926Danio rerio
 drd2bENSDARG00000011091Danio rerio
 DRD2ENSGALG00000007794Gallus gallus
 DRD2ENSG00000149295Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Drd3 / P30728 / D(3) dopamine receptor / P35462* / dopamine receptor D3*ENSMUSG0000002270551
Drd4 / P51436 / D(4) dopamine receptor / P21917* / dopamine receptor D4*ENSMUSG0000002549631
Drd5 / Q8BLD9 / D(1B) dopamine receptor / P21918* / dopamine receptor D5*ENSMUSG0000003935828
Htr2c / P34968 / 5-hydroxytryptamine (serotonin) receptor 2C / P28335* / 5-hydroxytryptamine receptor 2C*ENSMUSG0000004138027
Drd1 / Q61616 / D(1A) dopamine receptor / P21728* / dopamine receptor D1*ENSMUSG0000002147825
Adrb2 / P18762 / Beta-2 adrenergic receptor / P07550* / adrenoceptor beta 2*ENSMUSG0000004573025
Htr2a / P35363 / 5-hydroxytryptamine (serotonin) receptor 2A / P28223* / 5-hydroxytryptamine receptor 2A*ENSMUSG0000003499725
Htr2b / Q02152 / 5-hydroxytryptamine (serotonin) receptor 2B / P41595* / 5-hydroxytryptamine receptor 2B*ENSMUSG0000002622825
Adrb1 / P34971 / Beta-1 adrenergic receptor / P08588* / adrenoceptor beta 1*ENSMUSG0000003528325
Hrh2 / P97292 / Histamine H2 receptor / P25021* / histamine receptor H2*ENSMUSG0000003498725
Htr6 / Q9R1C8 / 5-hydroxytryptamine (serotonin) receptor 6 / P50406* / 5-hydroxytryptamine receptor 6*ENSMUSG0000002874723
Adrb3 / P25962 / Beta-3 adrenergic receptor / P13945* / adrenoceptor beta 3*ENSMUSG0000003148923


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000929  Dopamine receptor family
 IPR001922  Dopamine D2 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001659 temperature homeostasis IMP
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001963 synaptic transmission, dopaminergic IEA
 biological_processGO:0001964 startle response IMP
 biological_processGO:0001975 response to amphetamine IEA
 biological_processGO:0001976 neurological system process involved in regulation of systemic arterial blood pressure IMP
 biological_processGO:0002027 regulation of heart rate IMP
 biological_processGO:0002028 regulation of sodium ion transport IMP
 biological_processGO:0002031 G-protein coupled receptor internalization IEA
 biological_processGO:0002052 positive regulation of neuroblast proliferation IDA
 biological_processGO:0002092 positive regulation of receptor internalization IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007194 negative regulation of adenylate cyclase activity ISO
 biological_processGO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway ISO
 biological_processGO:0007212 dopamine receptor signaling pathway IGI
 biological_processGO:0007270 neuron-neuron synaptic transmission IMP
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007416 synapse assembly IEA
 biological_processGO:0007608 sensory perception of smell IMP
 biological_processGO:0007616 long-term memory IEA
 biological_processGO:0007625 grooming behavior IMP
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0007628 adult walking behavior IMP
 biological_processGO:0007631 feeding behavior IGI
 biological_processGO:0008104 protein localization IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0008306 associative learning IMP
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0009416 response to light stimulus IMP
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010039 response to iron ion IEA
 biological_processGO:0014059 regulation of dopamine secretion IMP
 biological_processGO:0014854 response to inactivity IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0021756 striatum development IEA
 biological_processGO:0021769 orbitofrontal cortex development IEA
 biological_processGO:0021853 cerebral cortex GABAergic interneuron migration IMP
 biological_processGO:0021984 adenohypophysis development IMP
 biological_processGO:0030336 negative regulation of cell migration IMP
 biological_processGO:0030432 peristalsis IMP
 biological_processGO:0030534 adult behavior IMP
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0031223 auditory behavior IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032228 regulation of synaptic transmission, GABAergic IMP
 biological_processGO:0032467 positive regulation of cytokinesis IEA
 biological_processGO:0032922 circadian regulation of gene expression IMP
 biological_processGO:0033602 negative regulation of dopamine secretion IEA
 biological_processGO:0034776 response to histamine IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0035556 intracellular signal transduction ISO
 biological_processGO:0035810 positive regulation of urine volume IMP
 biological_processGO:0035815 positive regulation of renal sodium excretion IMP
 biological_processGO:0040018 positive regulation of multicellular organism growth IMP
 biological_processGO:0042220 response to cocaine IMP
 biological_processGO:0042321 negative regulation of circadian sleep/wake cycle, sleep IEA
 biological_processGO:0042417 dopamine metabolic process IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043266 regulation of potassium ion transport IEA
 biological_processGO:0043278 response to morphine IMP
 biological_processGO:0043408 regulation of MAPK cascade IEA
 biological_processGO:0043473 pigmentation IMP
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0045776 negative regulation of blood pressure IMP
 biological_processGO:0045824 negative regulation of innate immune response IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0046717 acid secretion IEA
 biological_processGO:0048148 behavioral response to cocaine IMP
 biological_processGO:0048149 behavioral response to ethanol IMP
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IMP
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0048755 branching morphogenesis of a nerve IMP
 biological_processGO:0050482 arachidonic acid secretion IEA
 biological_processGO:0050709 negative regulation of protein secretion IEA
 biological_processGO:0050804 modulation of chemical synaptic transmission IEA
 biological_processGO:0051481 negative regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway ISO
 biological_processGO:0051584 regulation of dopamine uptake involved in synaptic transmission IMP
 biological_processGO:0051586 positive regulation of dopamine uptake involved in synaptic transmission IMP
 biological_processGO:0051823 regulation of synapse structural plasticity IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IMP
 biological_processGO:0051967 negative regulation of synaptic transmission, glutamatergic IMP
 biological_processGO:0060124 positive regulation of growth hormone secretion IMP
 biological_processGO:0060134 prepulse inhibition IMP
 biological_processGO:0060158 phospholipase C-activating dopamine receptor signaling pathway IEA
 biological_processGO:0060160 negative regulation of dopamine receptor signaling pathway IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0090325 regulation of locomotion involved in locomotory behavior IEA
 biological_processGO:1900168 positive regulation of glial cell-derived neurotrophic factor secretion IEA
 biological_processGO:1900273 positive regulation of long-term synaptic potentiation IEA
 biological_processGO:1901386 negative regulation of voltage-gated calcium channel activity IEA
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0030139 endocytic vesicle IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0036126 sperm flagellum IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0060170 ciliary membrane IEA
 cellular_componentGO:0097730 non-motile cilium IEA
 molecular_functionGO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IDA
 molecular_functionGO:0004952 dopamine neurotransmitter receptor activity IDA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0035240 dopamine binding IEA
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Dopamine receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

Allelic Composition: Drd2tm1Low/Drd2+
Genetic Background: B6.129S2-Drd2tm1Low

 MP:0000465 gastrointestinal hemorrhage "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0000470 abnormal stomach morphology "malformation of the sac-like structure of the digestive canal between the esophagus and the small intestine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0000512 intestinal ulcer "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0000633 abnormal pituitary gland morphology "anomalous structure of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ungtm1Tld/Ungtm1Tld
Genetic Background: involves: 129P2/OlaHsd

 MP:0000635 pituitary gland hyperplasia "increased size of pituitary gland due to increased cell number" [J:63229, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000636 enlarged pituitary gland "increased size of pituitary gland" [J:50053]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: either: B6.129S2-Drd2tm1Low or (involves: 129S2/SvPas * C57BL/6)

 MP:0000646 enlarged adrenocortical cells "larger size of cells of the adrenal gland " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001188 hyperpigmentation "excess of pigment in any or all tissues or a part of a tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Hcn4tm1Sev/?
Genetic Background: Not Specified

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Drd2tm1Low/Drd2+
Genetic Background: B6.129S2-Drd2tm1Low

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Drd2tm1Schm/Drd2tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Drd2tm1Schm/Drd2tm1Schm
Genetic Background: B6.Cg-Drd2tm1Schm

Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: B6.Cg-Drd2tm1Schm Drd3tm1Schm

Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low/J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Thtm2Rpa/Thtm2Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: X/SryPOS
Genetic Background: C57BL/6J

Allelic Composition: Drd2tm1Yyw/Drd2tm1Yyw
Genetic Background: B6.129S4-Drd2tm1Yyw

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Thtm2Rpa/Thtm2Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Drd2tm1Schm/Drd2+,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Drd2tm1Low/Drd2+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

Allelic Composition: Drd2tm1Low/Drd2+
Genetic Background: B6.129S2-Drd2tm1Low

Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: 129S/Sv-Drd2tm1Low

Allelic Composition: Drd2tm1Low/Drd2+
Genetic Background: 129S/Sv-Drd2tm1Low

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

Allelic Composition: Drd2tm1Low/Drd2+
Genetic Background: B6.129S2-Drd2tm1Low

 MP:0001396 unidirectional circling "circling behavior in one direction only, either clockwise or counterclockwise" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: En1tm2(cre)Wrst/En1+,Lhx1tm1Tmj/Lhx1tm2.1Bhr,Lhx5tm1Lmgd/Lhx5tm1Lmgd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Grin2atm1.1Ppao/Grin2atm1.1Ppao
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Drd2tm3.1Ebo/Drd2tm3.1Ebo,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Drd2tm1Yyw/Drd2tm1Yyw
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Drd2tm1Yyw/Drd2tm1Yyw
Genetic Background: B6.129S4-Drd2tm1Yyw

Allelic Composition: Drd2tm1Ebo/Drd2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

Allelic Composition: Drd2tm1Low/Drd2+
Genetic Background: B6.129S2-Drd2tm1Low

Allelic Composition: Cm/+,Drd2tm1Low/Drd2tm1Low
Genetic Background: involves: 101/H * 129S2/SvPas * C3H/HeH * C3H/HeSn * C57BL/6J

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Drd2tm1Ebo/Drd2tm1Ebo,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Drd2tm3.1Ebo/Drd2tm3.1Ebo,Tg(Drd1a-cre)AGsc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

Allelic Composition: Drd2tm3.1Ebo/Drd2tm3.1Ebo,Tg(Drd1a-cre)AGsc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001438 aphagia "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
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Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Drd2tm1Schm/Drd2tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001506 limp posture "lack of rigidity of the carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001529 abnormal vocalization "an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:85479]
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Allelic Composition: Hcn4tm1Sev/?
Genetic Background: Not Specified

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22tm1Meg,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129/Sv * 129S4/SvJaeSor

 MP:0001666 abnormal nutrient absorption "anomalous ability of the body to take in constituents of food necessary for normal physiologic function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Drd2tm1Schm/Drd2tm1Schm
Genetic Background: B6.Cg-Drd2tm1Schm

Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: B6.Cg-Drd2tm1Schm Drd3tm1Schm

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low/J

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0001744 hypersecretion of cortisol 
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001748 increased circulating adrenocorticotropin level "elevated concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

 MP:0001905 abnormal dopamine level "greater or less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Drd2tm1Schm/Drd2tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Drd2tm3.1Ebo/Drd2tm3.1Ebo,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Drd2tm3.1Ebo/Drd2tm3.1Ebo,Tg(Drd1a-cre)AGsc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Drd2tm3.1Ebo/Drd2tm3.1Ebo,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001927 abnormal oestrous cycle (sensu Rodentia) "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002041 pituitary adenoma "appearance of benign neoplasms of the pituitary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Thtm2Rpa/Thtm2Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptgestm1.1Gaf/Ptgestm1.1Gaf,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Drd2tm3.1Ebo/Drd2tm3.1Ebo,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Drd2tm3.1Ebo/Drd2tm3.1Ebo,Tg(Drd1a-cre)AGsc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0002557 abnormal social/conspecific interaction "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Tg(Prl-cre)1Mrub/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0002570 alcohol aversion 
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Allelic Composition: Drd2tm1Low/Drd2+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002572 abnormal emotion/affect behavior "altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm3.1Ebo/Drd2tm3.1Ebo,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

 MP:0002676 uterine hyperplasia "increased size of the uterus due to increased cell number" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: either: B6.129S2-Drd2tm1Low or (involves: 129S2/SvPas * C57BL/6)

 MP:0002690 akinesia "absence of movement or loss of the ability to move such as temporary or prolonged paralysis or "freezing in place"" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:82238]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Drd2tm1Yyw/Drd2tm1Yyw
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Drd2tm1Yyw/Drd2tm1Yyw
Genetic Background: B6.129S4-Drd2tm1Yyw

Allelic Composition: Drd2tm1Ebo/Drd2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

Allelic Composition: Drd2tm1Low/Drd2+
Genetic Background: B6.129S2-Drd2tm1Low

Allelic Composition: Drd2tm1Ebo/Drd2tm1Ebo,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002803 abnormal operant conditional behavior "defects in the operant conditioning system refers to abnormalities in scheduled controlled behavior; behavioral assessment occurs in an automated chamber where responses are reinforced with food" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: B6.Cg-Drd2tm1.1Mrub Slc6a3tm1.1(cre)Bkmn

 MP:0002822 catalepsy "a condition characterized by inactivity, lack of response to stimuli, and a tendency to maintain an immobile posture; the limbs tend to remain in whatever position they are placed (waxy rigidity); occurs with some psychoses, nervous system drug toxicity, and other conditions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Drd2tm1Ebo/Drd2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: B6.Cg-Drd2tm1.1Mrub Slc6a3tm1.1(cre)Bkmn

 MP:0003088 abnormal prepulse inhibition "increase or decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91131]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low/J

 MP:0003119 abnormal digestive system development "dysmorphology of the organ system that converts ingested food to nutrients and energy" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0003245 abnormal GABA neuron morphology "malformation or absence of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low/J

 MP:0003271 abnormal duodenum morphology "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adora2atm1Jfc/Adora2atm1Jfc
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Drd2tm1(IL2RA)Koba/Drd2+
Genetic Background: B6.129P2-Drd2tm1(IL2RA)Koba

Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: 129S/Sv-Drd2tm1Low

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low/J

Allelic Composition: Drd2tm1Smoc/Drd2tm1Smoc,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0003371 decreased circulating estrogen level "reduction in the blood concentration of any substance that causes development of the female reproductive organs and secondary sexual characteristics" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low/J

 MP:0003462 abnormal response to novel odor "altered investigative behavior from controls in reactions associated with exposing an animal to a novel odor" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Dicer1tm1Gz/Dicer1tm1Gz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Drd2tm1Mok/Drd2tm1Mok
Genetic Background: involves: 129S/SvEv

Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: B6.Cg-Drd2tm1.1Mrub Slc6a3tm1.1(cre)Bkmn

 MP:0003546 decreased alcohol consumption "less than normal consumption of alcohol" [RGD:Rat Genome Database submission]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

 MP:0003862 decreased aggression towards males "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards male mice " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Stat1tm1Rds/Stat1tm1Rds,Stat2tm1Shnd/Stat2tm1Shnd
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

 MP:0003866 abnormal defecation "anomaly in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm1Ebo/Drd2tm1Ebo,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0003867 increased defecation "increase in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm1Schm/Drd2tm1Schm
Genetic Background: B6.Cg-Drd2tm1Schm

Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: B6.Cg-Drd2tm1Schm Drd3tm1Schm

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0003973 increased pituitary hormone level "greater than the expected amount of any of the pituitary hormones in the blood or tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dicer1tm1Gz/Dicer1tm1Gz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004163 abnormal adenophysis morphology "any malformation or absence of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: either: B6.129S2-Drd2tm1Low or (involves: 129S2/SvPas * C57BL/6)

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low/J

Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

Allelic Composition: Drd2tm1Low/Drd2+
Genetic Background: B6.129S2-Drd2tm1Low

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Drd2tm1Ebo/Drd2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Drd2tm1Ebo/Drd2tm1Ebo,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low/J

 MP:0005117 increased circulating pituitary hormone level "greater than expected concentraton of any of the pituitary hormones in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005120 decreased circulating growth hormone level "less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low/J

 MP:0005124 increased circulating prolactin level "greater than expected blood concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: either: B6.129S2-Drd2tm1Low or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low/J

Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Tg(Prl-cre)1Mrub/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0005136 decreased growth hormone level "less than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0005137 increased growth hormone level "greater than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low/J

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Drd2tm1Yyw/Drd2tm1Yyw
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Drd2tm1Schm/Drd2tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005409 darkened coat color "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreasesd when compared to wild-type agouti" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Dicer1tm1Gz/Dicer1tm1Gz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dicer1tm1Gz/Dicer1tm1Gz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005573 increased breathing frequency "greater than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

 MP:0005575 increased pulmonary ventilation "greater than the normal total volume of gas per minute inspired or expired " [RGD:Rat Genome Database submission]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

 MP:0005576 decreased pulmonary ventilation "less than the normal total volume of gas per minute inspired or expired " [RGD:Rat Genome Database submission]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

 MP:0005585 increased tidal volume "greater than the normal volume of air inspired or expired during each normal respiratory cycle" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
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Allelic Composition: Cm/+,Drd2tm1Low/Drd2tm1Low
Genetic Background: involves: 101/H * 129S2/SvPas * C3H/HeH * C3H/HeSn * C57BL/6J

 MP:0005645 abnormal hypothalamus physiology "anomalous function of the ventral and medial region of the diencephalon forming the walls of the ventral half of the third ventricle, which is normally involved in the functions of the autonomic (visceral motor) nervous system and, through its vascular link with the anterior lobe of the pituitary gland, in endocrine mechanisms" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0005646 abnormal pituitary gland physiology "anmalous function of this unpaired compound gland suspended from the base of the hypothalamus by a short extension of the infundibulum, the infundibular or pituitary stalk" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006001 abnormal intestinal transit time "increase or decrease in the time it takes for a bolus of material to pass through the intestine" [smb:Susan M Bello, Mouse Genome Iformatics Curator]
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Allelic Composition: Drd2tm1Schm/Drd2tm1Schm
Genetic Background: B6.Cg-Drd2tm1Schm

Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: B6.Cg-Drd2tm1Schm Drd3tm1Schm

 MP:0006003 abnormal large intestinal transit time "increase or decrease in the time it takes for a bolus of material to pass through the large intestine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm1Schm/Drd2tm1Schm
Genetic Background: B6.Cg-Drd2tm1Schm

Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: B6.Cg-Drd2tm1Schm Drd3tm1Schm

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low/J

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

Allelic Composition: Drd2tm1Low/Drd2+
Genetic Background: B6.129S2-Drd2tm1Low

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

Allelic Composition: Drd2tm1Low/Drd2+
Genetic Background: B6.129S2-Drd2tm1Low

 MP:0006299 abnormal latent inhibition of conditioning behavior "anomaly in the impairment in a conditioned response seen after repeated unpaired presentations of the conditioned stimulus prior to pairing it with the unconditioned stimulus" [Additction research lab:http://dionysus.psych.wisc.edu/ARL/research-current.html, brs:Beverly Richards-Smith_IMSR Curator, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

 MP:0006316 increased urine sodium level "higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

 MP:0008235 increased susceptibility to neuronal excitotoxicity "greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: B6.129S2-Drd2tm1Ebo

 MP:0008294 abnormal zona fasciculata morphology "any structural anomaly of the wide middle zone of the adrenal cortex that produces cortisol (hydrocortisone)" [MESH:A06.407.071.140.950]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008295 abnormal zona reticularis morphology "any structural anomaly of the inner zone of the adrenal cortex that produces the enzymes that convert pregnenolone, a 21-carbon steroid, to 19-carbon steroids" [MESH:A06.407.071.140.970]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008299 adrenal cortical hyperplasia "overdevelopment of the thick outer layer of the adrenal gland that produces and secretes steroid hormones, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008324 abnormal melanotroph morphology "any structural anomaly of a cell of the intermediate pituitary that produces melanocyte stimulating hormone and other peptides from the post-translational processing of pro-opiomelanocortin (POMC)" [CL:0000440, MESH:A06.407.747.671.500]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008329 decreased somatotroph cell number "reduced number of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [CL:0000295, MESH:A06.407.747.608.937]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0008331 increased lactotroph cell number "greater number of an acidophilic cell of the anterior pituitary that produces prolactin" [CL:0000439, MESH:A06.407.747.608.812]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: either: B6.129S2-Drd2tm1Low or (involves: 129S2/SvPas * C57BL/6)

 MP:0008335 decreased gonadotroph cell number "reduced number of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)" [MESH:A06.407.747.608.750]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: either: B6.129S2-Drd2tm1Low or (involves: 129S2/SvPas * C57BL/6)

 MP:0008337 increased thyrotroph cell number "greater number of an anterior pituitary cell that produces thyroid-stimulating hormone" [MESH:A06.407.747.608.968]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008370 enlarged pituitary intermediate lobe "increased size of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dicer1tm1Gz/Dicer1tm1Gz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008371 pituitary intermediate lobe hyperplasia "overdevelopment or increased size, usually due to increased cell number, of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008423 decreased lactotroph cell size "reduced growth or small size of an acidophilic cell of the anterior pituitary that produces prolactin" [MESH:A06.407.747.608.812, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low/J

 MP:0008802 abnormal intestinal smooth muscle morphology "any structural anomaly of the nonstriated, involuntary muscle tissue lining the intestine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm1Low/Drd2+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: B6.Cg-Drd2tm1.1Mrub Slc6a3tm1.1(cre)Bkmn

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: either: B6.129S2-Drd2tm1Low or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low/J

Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: B6.Cg-Drd2tm1.1Mrub Slc6a3tm1.1(cre)Bkmn

Allelic Composition: Drd2tm3.1Ebo/Drd2tm3.1Ebo,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Drd2tm3.1Ebo/Drd2tm3.1Ebo,Tg(Drd1a-cre)AGsc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Tg(Prl-cre)1Mrub/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0008911 induced hyperactivity "increased physical activity following stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: B6.Cg-Drd2tm1.1Mrub Slc6a3tm1.1(cre)Bkmn

Allelic Composition: Drd2tm3.1Ebo/Drd2tm3.1Ebo,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0008916 abnormal astrocyte physiology "any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low/J

Allelic Composition: Drd2tm1Smoc/Drd2tm1Smoc,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low/J

 MP:0008939 increased pituitary gland weight "greater than average weight of the compound gland suspended from the base of the hypothalamus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: either: B6.129S2-Drd2tm1Low or (involves: 129S2/SvPas * C57BL/6)

 MP:0009011 prolonged diestrus "increase in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009016 abnormal estrus "any anomaly or aberrant timing of the phase of the estrous cycle which begins with the ovulation of fully mature oocytes and during which the vulva remains in an extended state with an open vagina, and females are maximally receptive to male advances" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009082 uterus cysts "presence of fluid-filled structures inside the lumen of the uterus; usually refers to benign growths" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: either: B6.129S2-Drd2tm1Low or (involves: 129S2/SvPas * C57BL/6)

 MP:0009089 short uterine horn "length reduction or truncation of either one of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: either: B6.129S2-Drd2tm1Low or (involves: 129S2/SvPas * C57BL/6)

 MP:0009221 uterus adenomyosis "a benign invasion of myometrium by endometrial tissue" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: either: B6.129S2-Drd2tm1Low or (involves: 129S2/SvPas * C57BL/6)

 MP:0009293 decreased inguinal fat pad weight 
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low/J

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0009712 impaired conditioned place preference behavior "decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009745 abnormal behavioral response to xenobiotic "any anomaly in the behavioral response induced by a foreign compound, such as consumption preference, induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm1Yyw/Drd2tm1Yyw
Genetic Background: B6.129S4-Drd2tm1Yyw

Allelic Composition: Drd2tm1Yyw/Drd2+
Genetic Background: B6.129S4-Drd2tm1Yyw

 MP:0009746 enhanced behavioral response to xenobiotic "increased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or reduced dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak3wil/Jak3wil
Genetic Background: C57BL/6JSfdAnu-Jak3wil/Anu

Allelic Composition: Drd2tm3.1Ebo/Drd2tm3.1Ebo,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm1Yyw/Drd2tm1Yyw
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Drd2tm2Ebo/Drd2tm2Ebo
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009750 impaired behavioral response to addictive substance "decreased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

 MP:0009754 enhanced behavioral response to cocaine "increased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: B6.Cg-Drd2tm1.1Mrub Slc6a3tm1.1(cre)Bkmn

Allelic Composition: Drd2tm3.1Ebo/Drd2tm3.1Ebo,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0009755 impaired behavioral response to alcohol "decreased sensitivity to alcohol resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low

Allelic Composition: Drd2tm1Low/Drd2+
Genetic Background: B6.129S2-Drd2tm1Low

 MP:0009758 impaired behavioral response to cocaine "decreased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm3.1Ebo/Drd2tm3.1Ebo,Tg(Drd1a-cre)AGsc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low/J

 MP:0009778 impaired behavioral response to anesthetic "decrease or delay in the behavioral changes that follow exposure to a given amount of an anesthetizing agent" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm3.1Ebo/Drd2tm3.1Ebo,Tg(Drd1a-cre)AGsc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

 MP:0009779 enhanced behavioral response to anesthetic "increase or exceleration in the behavioral changes that follow exposure to a given amount of an anesthetizing agent" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm3.1Ebo/Drd2tm3.1Ebo,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0010149 abnormal synaptic dopamine release "aberrant secretion across synapses of the catecholamine neurotransmitter and neurohormone, derived from tyrosine and the precursor to norepinephrine and epinephrine; functions as a neurotransmitter in the brain and as a hormone to inhibit the release of prolactin from the anterior lobe of the pituitary" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: B6.Cg-Drd2tm1.1Mrub Slc6a3tm1.1(cre)Bkmn

 MP:0010167 decreased response to stress-induced hyperthermia "reduction or absence of the expected increase in core body termperature in response to stress or anticipatory anxiety" [PMID:18722480]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low/J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011448 decreased dopaminergic neuron number "fewer than normal numbers of the neurons that utilize dopamine as a neurotransmitter" [MGI:smb]
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Allelic Composition: Drd2tm1(IL2RA)Koba/Drd2+
Genetic Background: B6.129P2-Drd2tm1(IL2RA)Koba

 MP:0011451 increased susceptibility to dopaminergic neuron neurotoxicity "greater than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low/J

 MP:0011532 decreased urine major urinary protein level "reduced amount in the urine of a family of alpha2-microglobulin-related liver secretory proteins that comprise a major protein component of mouse urine" [MGI:csmith]
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Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Drd2tm1Schm/Drd2tm1Schm
Genetic Background: B6.Cg-Drd2tm1Schm

Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: B6.Cg-Drd2tm1Schm Drd3tm1Schm

Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: B6.129S2-Drd2tm1Low/J

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Drd2tm1Schm/Drd2tm1Schm
Genetic Background: B6.Cg-Drd2tm1Schm

Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: B6.Cg-Drd2tm1Schm Drd3tm1Schm

 MP:0011942 decreased fluid intake "reduction in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0013334 adenohypophysis peliosis "presence of cyst-like blood-filled lakes or cavities (extravasated erythrocytes not contained in capillaries) within the anterior lobe of the pituitary gland" [MGI:Anna, PMID:15734106]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: either: B6.129S2-Drd2tm1Low or (involves: 129S2/SvPas * C57BL/6)

 MP:0013348 adenohypophysis hyperplasia " overdevelopment or increased size of the anterior lobe of the pituitary gland, usually due to increased cell number" [MGI:Anna]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: either: B6.129S2-Drd2tm1Low or (involves: 129S2/SvPas * C57BL/6)

 MP:0013355 adenohypophysis hypertrophy "increase in the bulk size of the anterior lobe of the pituitary gland due to cell enlargement" [MGI:Anna]
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Allelic Composition: Drd2tm1Low/Drd2tm1Low
Genetic Background: either: B6.129S2-Drd2tm1Low or (involves: 129S2/SvPas * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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