ENSDARG00000056926


Danio rerio

Features
Gene ID: ENSDARG00000056926
  
Biological name :drd2a
  
Synonyms : dopamine receptor D2a / drd2a
  
Possible biological names infered from orthology : D(2) dopamine receptor / dopamine receptor D2 / DRD2 / P14416 / P61168
  
Species: Danio rerio
  
Chr. number: 15
Strand: -1
Band:
Gene start: 22046557
Gene end: 22074315
  
Corresponding Affymetrix probe sets: DrAffx.1.28.S1_at (Zebrafish Array)   NM_183068_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000123971
Ensembl peptide - ENSDARP00000153646
NCBI entrez gene - 282557     See in Manteia.
RefSeq - NM_183068
RefSeq Peptide - NP_898891
swissprot - Q8AWE0
ZFIN ID - ZDB-GENE-021119-2
Ensembl - ENSDARG00000056926
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DRD2ENSGALG00000007794Gallus gallus
 DRD2ENSG00000149295Homo sapiens
 Drd2ENSMUSG00000032259Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
drd2b / dopamine receptor D2b / DRD2* / P61168* / P14416* / dopamine receptor D2* / D(2) dopamine receptor *ENSDARG0000001109171
drd2l / dopamine receptor D2 likeENSDARG0000001485855
drd3 / dopamine receptor D3 / P30728* / P35462* / D(3) dopamine receptor *ENSDARG0000003213150
drd4-rs / dopamine receptor D4 related sequenceENSDARG0000000191232
drd4b / dopamine receptor D4b / DRD4* / P51436* / P21917* / dopamine receptor D4* / D(4) dopamine receptor *ENSDARG0000003582032
drd4a / dopamine receptor D4a / DRD4* / P51436* / P21917* / dopamine receptor D4* / D(4) dopamine receptor *ENSDARG0000003836332
adrb1 / adrenoceptor beta 1 / P08588* / P34971* / Beta-1 adrenergic receptor *ENSDARG0000000749027
drd6b / dopamine receptor D6bENSDARG0000004076526
AL935174.5ENSDARG0000011512926
drd1a / dopamine receptor D1a / DRD1* / Q61616* / P21728* / dopamine receptor D1* / D(1A) dopamine receptor *ENSDARG0000007164026
drd7 / dopamine receptor D7ENSDARG0000005628425
BX530018.1 / DRD5* / P21918* / dopamine receptor D5*ENSDARG0000003757625
drd1b / dopamine receptor D1b / DRD1* / P21728* / dopamine receptor D1*ENSDARG0000003891825
htr2b / 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled / P41595* / 5-hydroxytryptamine receptor 2B*ENSDARG0000011592525
htr2aa / 5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a / HTR2A* / P35363* / P28223* / 5-hydroxytryptamine receptor 2A* / 5-hydroxytryptamine (serotonin) receptor 2A*ENSDARG0000005702925
htr2ab / 5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate b / HTR2A* / P35363* / P28223* / 5-hydroxytryptamine receptor 2A* / 5-hydroxytryptamine (serotonin) receptor 2A*ENSDARG0000005816525
htr2cl1 / 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 / HTR2C* / P34968* / P28335* / 5-hydroxytryptamine receptor 2C* / 5-hydroxytryptamine (serotonin) receptor 2C*ENSDARG0000001822824
adrb2b / adrenoceptor beta 2, surface b / ADRB2* / P18762* / P07550* / adrenoceptor beta 2* / Beta-2 adrenergic receptor *ENSDARG0000005451024
adrb2a / adrenoceptor beta 2, surface a / ADRB2* / P18762* / P07550* / adrenoceptor beta 2* / Beta-2 adrenergic receptor *ENSDARG0000008812424
htr2cl2 / 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 2ENSDARG0000001321024


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000929  Dopamine receptor family
 IPR001922  Dopamine D2 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001963 synaptic transmission, dopaminergic IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007194 negative regulation of adenylate cyclase activity IBA
 biological_processGO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway IBA
 biological_processGO:0007212 dopamine receptor signaling pathway ISS
 biological_processGO:0009636 response to toxic substance IBA
 biological_processGO:0014059 regulation of dopamine secretion IBA
 biological_processGO:0042493 response to drug IBA
 biological_processGO:0043266 regulation of potassium ion transport IBA
 biological_processGO:0048148 behavioral response to cocaine IBA
 biological_processGO:0048149 behavioral response to ethanol IBA
 biological_processGO:0051481 negative regulation of cytosolic calcium ion concentration IBA
 biological_processGO:0051967 negative regulation of synaptic transmission, glutamatergic IBA
 biological_processGO:0060158 phospholipase C-activating dopamine receptor signaling pathway IBA
 biological_processGO:1901386 negative regulation of voltage-gated calcium channel activity IBA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISS
 cellular_componentGO:0030672 synaptic vesicle membrane IBA
 molecular_functionGO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004952 dopamine neurotransmitter receptor activity IEA
 molecular_functionGO:0035240 dopamine binding IBA


Pathways (from Reactome)
Pathway description
Dopamine receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain decreased size , abnormal
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 ZFA:0000114 heart heart congested , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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