ENSMUSG00000026228


Mus musculus

Features
Gene ID: ENSMUSG00000026228
  
Biological name :Htr2b
  
Synonyms : 5-hydroxytryptamine (serotonin) receptor 2B / Htr2b / Q02152
  
Possible biological names infered from orthology : 5-hydroxytryptamine receptor 2B / P41595
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C5
Gene start: 86099026
Gene end: 86111970
  
Corresponding Affymetrix probe sets: 10356305 (MoGene1.0st)   1422125_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027431
Ensembl peptide - ENSMUSP00000116273
NCBI entrez gene - 15559     See in Manteia.
MGI - MGI:109323
RefSeq - XM_006529147
RefSeq - NM_008311
RefSeq - XM_006529145
RefSeq - XM_006529146
RefSeq Peptide - NP_032337
swissprot - G3UVT8
swissprot - Q02152
Ensembl - ENSMUSG00000026228
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 htr2bENSDARG00000115925Danio rerio
 HTR2BENSGALG00000007681Gallus gallus
 HTR2BENSG00000135914Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Htr2a / P35363 / 5-hydroxytryptamine (serotonin) receptor 2A / P28223* / 5-hydroxytryptamine receptor 2A*ENSMUSG0000003499743
Htr2c / P34968 / 5-hydroxytryptamine (serotonin) receptor 2C / P28335* / 5-hydroxytryptamine receptor 2C*ENSMUSG0000004138038
Drd5 / Q8BLD9 / D(1B) dopamine receptor / P21918* / dopamine receptor D5*ENSMUSG0000003935823
Drd4 / P51436 / D(4) dopamine receptor / P21917* / dopamine receptor D4*ENSMUSG0000002549623
Drd1 / Q61616 / D(1A) dopamine receptor / P21728* / dopamine receptor D1*ENSMUSG0000002147823
Drd2 / P61168 / D(2) dopamine receptor / P14416* / dopamine receptor D2*ENSMUSG0000003225923
Htr6 / Q9R1C8 / 5-hydroxytryptamine (serotonin) receptor 6 / P50406* / 5-hydroxytryptamine receptor 6*ENSMUSG0000002874722
Adrb2 / P18762 / Beta-2 adrenergic receptor / P07550* / adrenoceptor beta 2*ENSMUSG0000004573022
Adrb1 / P34971 / Beta-1 adrenergic receptor / P08588* / adrenoceptor beta 1*ENSMUSG0000003528322
Drd3 / P30728 / D(3) dopamine receptor / P35462* / dopamine receptor D3*ENSMUSG0000002270522
Adrb3 / P25962 / Beta-3 adrenergic receptor / P13945* / adrenoceptor beta 3*ENSMUSG0000003148921
Hrh2 / P97292 / Histamine H2 receptor / P25021* / histamine receptor H2*ENSMUSG0000003498719


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000482  5-Hydroxytryptamine 2B receptor
 IPR002231  5-hydroxytryptamine receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0001819 positive regulation of cytokine production IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0002031 G-protein coupled receptor internalization IDA
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0003300 cardiac muscle hypertrophy IMP
 biological_processGO:0006182 cGMP biosynthetic process IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0006939 smooth muscle contraction IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007202 activation of phospholipase C activity IEA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IMP
 biological_processGO:0007208 phospholipase C-activating serotonin receptor signaling pathway TAS
 biological_processGO:0007210 serotonin receptor signaling pathway IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007610 behavior IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010507 negative regulation of autophagy IEA
 biological_processGO:0010513 positive regulation of phosphatidylinositol biosynthetic process IEA
 biological_processGO:0014033 neural crest cell differentiation IMP
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0014827 intestine smooth muscle contraction IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0042310 vasoconstriction IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0048598 embryonic morphogenesis IMP
 biological_processGO:0050715 positive regulation of cytokine secretion IMP
 biological_processGO:0050795 regulation of behavior IEA
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051781 positive regulation of cell division IMP
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0070371 ERK1 and ERK2 cascade IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070528 protein kinase C signaling IEA
 biological_processGO:0071502 cellular response to temperature stimulus IDA
 biological_processGO:0098664 G-protein coupled serotonin receptor signaling pathway IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004993 G-protein coupled serotonin receptor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IMP
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0030594 neurotransmitter receptor activity IBA
 molecular_functionGO:0051378 serotonin binding IEA


Pathways (from Reactome)
Pathway description
Serotonin receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

 MP:0000296 absent ventricular trabeculae "missing supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:45302]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0010759 decreased right ventricle systolic pressure "decrease in the pressure in the right ventricle as the heart contracts and pumps blood into the arteries" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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