ENSGALG00000007681


Gallus gallus

Features
Gene ID: ENSGALG00000007681
  
Biological name :HTR2B
  
Synonyms : 5-hydroxytryptamine receptor 2B / HTR2B
  
Possible biological names infered from orthology : 5-hydroxytryptamine (serotonin) receptor 2B / P41595 / Q02152
  
Species: Gallus gallus
  
Chr. number: 9
Strand: -1
Band:
Gene start: 15205069
Gene end: 15214169
  
Corresponding Affymetrix probe sets: Gga.320.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000012437
NCBI entrez gene - 395581     See in Manteia.
RefSeq - NM_001290547
RefSeq Peptide - NP_001277476
swissprot - F1NU82
Ensembl - ENSGALG00000007681
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 htr2bENSDARG00000115925Danio rerio
 HTR2BENSG00000135914Homo sapiens
 Htr2bENSMUSG00000026228Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HTR2A / Gallus gallus 5-hydroxytryptamine receptor 2A (HTR2A), mRNA. / P28223* / P35363* / 5-hydroxytryptamine receptor 2A* / 5-hydroxytryptamine (serotonin) receptor 2A*ENSGALG0000001699243
HTR2C / Gallus gallus 5-hydroxytryptamine receptor 2C (HTR2C), mRNA. / P28335* / P34968* / 5-hydroxytryptamine receptor 2C* / 5-hydroxytryptamine (serotonin) receptor 2C*ENSGALG0000000585343
DRD2 / dopamine receptor D2 / P14416* / P61168* / D(2) dopamine receptor *ENSGALG0000000779425
DRD1 / dopamine receptor D1 / P21728* / Q61616* / D(1A) dopamine receptor *ENSGALG0000003969824
DRD4 / dopamine receptor D4 / P21917* / P51436* / D(4) dopamine receptor *ENSGALG0000004076124
DRD5 / dopamine receptor D5 / P21918* / Q8BLD9* / D(1B) dopamine receptor *ENSGALG0000001497523
DRD3 / dopamine receptor D3 / P30728* / P35462* / D(3) dopamine receptor *ENSGALG0000001511723
DD1CR / dopamine D1C receptor ENSGALG0000000654023
HTR6 / 5-hydroxytryptamine receptor 6 / P50406* / Q9R1C8* / 5-hydroxytryptamine (serotonin) receptor 6*ENSGALG0000000406622
ADRB3 / adrenoceptor beta 3 / P13945* / P25962* / Beta-3 adrenergic receptor *ENSGALG0000001901822
HRH2 / histamine receptor H2 / P25021* / P97292* / Histamine H2 receptor *ENSGALG0000002417121
ADRB1 / adrenoceptor beta 1 / P08588* / P34971* / Beta-1 adrenergic receptor *ENSGALG0000000894921
ADRB2 / adrenoceptor beta 2 / P07550* / P18762* / Beta-2 adrenergic receptor *ENSGALG0000004003521
ENSGALG0000001595320


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000482  5-Hydroxytryptamine 2B receptor
 IPR002231  5-hydroxytryptamine receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IEA
 biological_processGO:0001819 positive regulation of cytokine production IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0002031 G-protein coupled receptor internalization IEA
 biological_processGO:0003007 heart morphogenesis IEA
 biological_processGO:0003300 cardiac muscle hypertrophy IEA
 biological_processGO:0006182 cGMP biosynthetic process IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0006939 smooth muscle contraction IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007202 activation of phospholipase C activity IEA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007210 serotonin receptor signaling pathway IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010507 negative regulation of autophagy IEA
 biological_processGO:0010513 positive regulation of phosphatidylinositol biosynthetic process IEA
 biological_processGO:0014033 neural crest cell differentiation IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0014827 intestine smooth muscle contraction IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0042310 vasoconstriction IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0048598 embryonic morphogenesis IEA
 biological_processGO:0050715 positive regulation of cytokine secretion IEA
 biological_processGO:0050795 regulation of behavior IEA
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0070371 ERK1 and ERK2 cascade IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070528 protein kinase C signaling IEA
 biological_processGO:0071502 cellular response to temperature stimulus IEA
 biological_processGO:0098664 G-protein coupled serotonin receptor signaling pathway IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004993 G-protein coupled serotonin receptor activity IBA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0030594 neurotransmitter receptor activity IBA
 molecular_functionGO:0051378 serotonin binding IEA


Pathways (from Reactome)
Pathway description
Serotonin receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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