Manteia

ENSGALG00000008949

Gallus gallus

Features

Gene ID:	ENSGALG00000008949

Biological name :	ADRB1

Synonyms :	ADRB1 / adrenoceptor beta 1

Possible biological names infered from orthology :	Beta-1 adrenergic receptor / P08588 / P34971

Species:	Gallus gallus

Chr. number:	6
Strand:	1
Band:
Gene start:	27679147
Gene end:	27680421

Corresponding Affymetrix probe sets:	GgaAffx.5638.2.S1_s_at (Chicken Array)

Cross references:	Ensembl peptide - ENSGALP00000014538 swissprot - E1BWY5 Ensembl - ENSGALG00000008949

See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
adrb1	ENSDARG00000007490	Danio rerio
ADRB1	ENSG00000043591	Homo sapiens
Adrb1	ENSMUSG00000035283	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
ADRB3 / adrenoceptor beta 3 / P13945* / P25962* / Beta-3 adrenergic receptor *	ENSGALG00000019018	51
ADRB2 / adrenoceptor beta 2 / P07550* / P18762* / Beta-2 adrenergic receptor *	ENSGALG00000040035	48
DRD5 / dopamine receptor D5 / P21918* / Q8BLD9* / D(1B) dopamine receptor *	ENSGALG00000014975	33
DD1CR / dopamine D1C receptor	ENSGALG00000006540	33
DRD1 / dopamine receptor D1 / P21728* / Q61616* / D(1A) dopamine receptor *	ENSGALG00000039698	33
HTR6 / 5-hydroxytryptamine receptor 6 / P50406* / Q9R1C8* / 5-hydroxytryptamine (serotonin) receptor 6*	ENSGALG00000004066	27
HRH2 / histamine receptor H2 / P25021* / P97292* / Histamine H2 receptor *	ENSGALG00000024171	27
	ENSGALG00000015953	26
DRD3 / dopamine receptor D3 / P30728* / P35462* / D(3) dopamine receptor *	ENSGALG00000015117	26
DRD2 / dopamine receptor D2 / P14416* / P61168* / D(2) dopamine receptor *	ENSGALG00000007794	26
HTR2A / Gallus gallus 5-hydroxytryptamine receptor 2A (HTR2A), mRNA. / P28223* / P35363* / 5-hydroxytryptamine receptor 2A* / 5-hydroxytryptamine (serotonin) receptor 2A*	ENSGALG00000016992	25
HTR2C / Gallus gallus 5-hydroxytryptamine receptor 2C (HTR2C), mRNA. / P28335* / P34968* / 5-hydroxytryptamine receptor 2C* / 5-hydroxytryptamine (serotonin) receptor 2C*	ENSGALG00000005853	24
DRD4 / dopamine receptor D4 / P21917* / P51436* / D(4) dopamine receptor *	ENSGALG00000040761	23
HTR2B / 5-hydroxytryptamine receptor 2B / P41595* / Q02152* / 5-hydroxytryptamine (serotonin) receptor 2B*	ENSGALG00000007681	23

Protein motifs (from Interpro)

Interpro ID	Name
IPR000276	G protein-coupled receptor, rhodopsin-like
IPR000507	Beta 1 adrenoceptor
IPR002233	Adrenoceptor family
IPR017452	GPCR, rhodopsin-like, 7TM

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001659	temperature homeostasis	IBA
biological_process	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine	IEA
biological_process	GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine	IEA
biological_process	GO:0002024	diet induced thermogenesis	IEA
biological_process	GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IEA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007267	cell-cell signaling	IBA
biological_process	GO:0009409	response to cold	IEA
biological_process	GO:0030819	obsolete positive regulation of cAMP biosynthetic process	IEA
biological_process	GO:0031649	heat generation	IEA
biological_process	GO:0040015	negative regulation of multicellular organism growth	IEA
biological_process	GO:0042596	fear response	IEA
biological_process	GO:0043547	positive regulation of GTPase activity	IEA
biological_process	GO:0043950	positive regulation of cAMP-mediated signaling	IEA
biological_process	GO:0045823	positive regulation of heart contraction	IEA
biological_process	GO:0050873	brown fat cell differentiation	IEA
biological_process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	IEA
cellular_component	GO:0005769	early endosome	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0005887	integral component of plasma membrane	IBA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0004930	G-protein coupled receptor activity	IEA
molecular_function	GO:0004935	adrenergic receptor activity	IEA
molecular_function	GO:0004940	beta1-adrenergic receptor activity	IBA
molecular_function	GO:0005057	obsolete signal transducer activity, downstream of receptor	IEA
molecular_function	GO:0005088	Ras guanyl-nucleotide exchange factor activity	IEA
molecular_function	GO:0030165	PDZ domain binding	IEA
molecular_function	GO:0031694	alpha-2A adrenergic receptor binding	IEA
molecular_function	GO:0046982	protein heterodimerization activity	IEA
molecular_function	GO:0051379	epinephrine binding	IBA
molecular_function	GO:0051380	norepinephrine binding	IBA

Pathways (from Reactome)

Pathway description

Adrenoceptors

G alpha (s) signalling events

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr