ENSG00000113749


Homo sapiens

Features
Gene ID: ENSG00000113749
  
Biological name :HRH2
  
Synonyms : histamine receptor H2 / HRH2 / P25021
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q35.2
Gene start: 175658030
Gene end: 175710756
  
Corresponding Affymetrix probe sets: 220805_at (Human Genome U133 Plus 2.0 Array)   229373_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000489742
Ensembl peptide - ENSP00000490705
Ensembl peptide - ENSP00000231683
Ensembl peptide - ENSP00000366506
NCBI entrez gene - 3274     See in Manteia.
OMIM - 142703
RefSeq - XM_017009426
RefSeq - NM_022304
RefSeq - XM_005265904
RefSeq - XM_006714864
RefSeq - XM_011534548
RefSeq - XM_011534549
RefSeq - NM_001131055
RefSeq Peptide - NP_001124527
RefSeq Peptide - NP_071640
swissprot - A0A1B0GVZ0
swissprot - P25021
swissprot - A0A1B0GTK7
Ensembl - ENSG00000113749
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hrh2aENSDARG00000107444Danio rerio
 hrh2bENSDARG00000057479Danio rerio
 HRH2ENSGALG00000024171Gallus gallus
 Hrh2ENSMUSG00000034987Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DRD5 / P21918 / dopamine receptor D5ENSG0000016967631
ADRB1 / P08588 / adrenoceptor beta 1ENSG0000004359130
DRD1 / P21728 / dopamine receptor D1ENSG0000018484530
HTR6 / P50406 / 5-hydroxytryptamine receptor 6ENSG0000015874828
ADRB3 / P13945 / adrenoceptor beta 3ENSG0000018877828
DRD2 / P14416 / dopamine receptor D2ENSG0000014929527
DRD3 / P35462 / dopamine receptor D3ENSG0000015157726
ADRB2 / P07550 / adrenoceptor beta 2ENSG0000016925226
DRD4 / P21917 / dopamine receptor D4ENSG0000006969624
HTR2A / P28223 / 5-hydroxytryptamine receptor 2AENSG0000010246824
HTR2C / P28335 / 5-hydroxytryptamine receptor 2CENSG0000014724623
HTR2B / P41595 / 5-hydroxytryptamine receptor 2BENSG0000013591422


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000503  Histamine H2 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001696 gastric acid secretion IEA
 biological_processGO:0001697 histamine-induced gastric acid secretion IBA
 biological_processGO:0001698 gastrin-induced gastric acid secretion IEA
 biological_processGO:0003382 epithelial cell morphogenesis IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
 biological_processGO:0007613 memory IEA
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0048167 regulation of synaptic plasticity IEA
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0048732 gland development IEA
 biological_processGO:1901998 toxin transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004969 histamine receptor activity TAS


Pathways (from Reactome)
Pathway description
Histamine receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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